MOLECULAR-CELLULAR MECHANISMS OF DISTURBANCES OF THE BLOOD RHEOLOGICAL PROPERTIES UNDER INFLUENCE OF “MOUSE” TOXIN Y. PESTYS

The disturbances of the blood viscosity at different shear rates in dynamics of plaque intoxication were investigated. Experimental plaque intoxication of different degrees of severity was reached by parenteral administration to mice of a murine (“mouse”) toxin in doses equivalent to LD25 and LD50. Correlation between the intensification of lipoperoxidation and the degree of autointoxication severity and integrative indices of rheological properties of the blood of experimental mice was established.