Physiology and Pathophysiology

The purpose of research was studying of cytoprotective effect of cytoflavinum at a thermal trauma of different severity level. Materials and methods. 169 patients with thermal burns with a favorable outcome and gravity of a thermal trauma from 30 to 170 points on Franc were under research. 28 patients took standard dosage of cytoflavinum while complex therapy. Results. Patients with thermal trauma more than 60 points on Franc took Cytoflavinumuse and demonstrated decrease in intensity of system inflammatory response syndrome (SIRS), reduction of band neutrophils portion, lowering of erythrocyte number, smaller activation ofthrombocytopoiesis, dicrease of concentration of vascular endothelial growth factor. Positive effect was not revealed in group of patients with thermal trauma less than 60 points who received cytoflavinum. Conclusion. Use of cytoflavinum was the most effective at thermal trauma gravity more than 60 points on Franc

Aim. To study the interrelation between the nature of system metabolic disturbances, rheological properties and cell composition of peripheral blood and the dynamics of the development of alterative and necrotic, regenerative and proliferative processes in a zone of surface thermal injury of the skin. Materials and methods. Complex clinical and laboratory examination of 30 patients suffering from surface burns (first-, second-, and third A degrees) was conducted. Results and conclusion: The examination allowed determining the interrelation of the severity of local destructive changes in a thermal injury zone and the nature of system metabolic disturbances typical for the system inflammatory response syndrome with the degree of lipid peroxidation process activation, insufficient activity of antioxidant blood system, increase in blood viscosity properties and cell composition

The purpose of the research: to study the relation of the voluntary visual attention to the self-regulation of different functional information comprehension systems. The object of the research: 196 individuals, aged 18-26 years, having no complaints of their health status. The techniques used: those of comprehension and measuring the pure tone length, the spatio-temporal parameters of the stimulus and the instrumental-software complex for studying the properties of attention. The results of the research have demonstrated that realizing its properties through the control functions attention exerts an active influence on the functional comprehension systems self-regulation. Conclusion: We have proved the integration of the function of attention into the self-regulation processes

The effect of electromagnetic radiation in the terahertz range frequencies of molecular spectrum of emission and absorption of nitric oxide 150.176–150.664 GHz for the restoration of the impaired carbohydrate component and functional activity glikoproteid receptors of erythrocytes of white rats in a state of acute imm obilization stress. Shown that exposure to electromagnetic waves at these frequencies is the normalization of the increased content of b-D-galactose in the carbohydrate component and the restoration of the impaired activity of the receptors glikoproteid erythrocytes

The subject of the article is to investigate the mechanism of increased reactions by electrical stimulation of the sympathetic nerve. Materials and methods: Experiments on dogs have shown that stimulant reactions during blockade of a-adrenergic by phentolamine and (3-adrenergic receptors with propranolol were completely eliminated by lizer-gol —the blocker of 5-HT12-receptors. Results: Infusion of lizergol did not influence on duodenal motor activity and the function of the vagus nerve. Conclusion: Effector neuron is found out to be serotonergic and its action is provided by 5-HT1 2 receptors

The investigation has revealed that stimulation of sympathetic nerve in the thoracic cavity in dogs provides no inhibition but increase in stomach contractions in most cases. This effect is raised with the blockage of a-and (3-adrenergic receptors and it is removed by blockage of 5-HT12-receptors. It has been stated that there are serotonergic fibers that increase stomach contractility

The article presents the study on the effect of SHF radiation of 0.01-0.2-mcW/cml intensity on alveolar-capillary permeability state and rat survival with hemodynamic adrenaline pulmonary edema in vitro. Animals of different sex showed dissimilar sensitivity to edema adrenaline action and to super high frequency of SHF radiation. SHF radiation of 0,05 MW/cml is optimal from the viewpoint of its effect for the period of survival of both male and female rats, accompanied by prolongation of their life span to 59.2% and 95.5% respectively. The hypothesis of modulating action of low intensity SHF radiation on endothelial functional state has been considered. It results in rehabilitation of cardiovascular system reactivity and significant prolongation of life span.

Realization of professional duties for specialist of medical-social expertise is accompanied with high intellectual and emotional obligations. Daily extreme and psychogenic situations lead to psychological and occupational maladjustment of physicians, development of anxiety and depression among them, which can be exacerbated by the presence of alexithymia. Negative psycho-emotional factors increase the risk of coronary heart disease. In order to prevent this pathology development in specialists of medical-social expertise, identification of changes in their psycho-emotional sphere and personified correction of revealed disorders are necessary

When analyzing the results of psychophysiological study of healthy individuals aged 18 to 30 years with an average teeth resistance to caries of harmonious and anxious personality types, it was revealed that the number of representatives of anxious type were more than of harmonic type; and high neuroticism, anxiety and conflicting intrapersonal tendencies which are the risk factors for dental caries origin and progression, were observed in their personal radical. In this regard, the plan of preventive arrangements for carious process progression in clinically healthy persons of anxious psycho-type seems to be the rational measure

The research work presents an analysis of literature review and results of investigations on the problems of etiology, pathogenesis, classification and peculiarities of clinical manifestations of chronic lymphocytic leukaemia. Special attention is paid to both contemporary conceptions of carcinogenesis, reflecting the role of proto-oncogenes activation, an-tioncogenes and apoptosis genes suppression in mechanisms of neoplasia development and «specific mechanisms» of oncogenic transformation induction of B-lymphocytes and the subsequent development of the stages of promotion, progression and marked clinical manifestations of formation. Possibility of further improvement of use of immune phe-notype character and oncomarkers in diagnostics of chronic lymphocytic leukaemia clinical variants and in evaluation of effectiveness of its therapy has been indicated in the article