Saratov JOURNAL of Medical and Scientific Research

Saratov State Medical University

www.sgmu.ru

Morphofunctional state of spleening under light desynchronosis in the experiment

Year: 2018, volume 14 Issue: №3 Pages: 533-536
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Zlobina O.V., Ivanov A.N., Karetnikova A.Yu., Terekhina E.S., Bugaeva I.O.
Organization: Saratov State Medical University
Summary:

 Aim: to study the effects of light desynchronosis on the morphofunctional state of the spleen of white male rats. Material and Methods. The study of light desynchronosis was carried out on 48 male rats using the Light Light model with an illumination power of 300 Ix in the daylight and 500 Ix in the dark. The laboratory animals in the experiment were divided into four groups: the control and three experimental ones, in which they were exposed to light for 1 day, 10 days, 21 days respectively. In the course of morphometry of histological sections of the spleen, the following parameters were assessed: the area of white pulp lymphoid follicles, B- and T-clependent zones of white pulp, the number of germinative centers and immunoblasts in B- and T-zones. Results. On day 1 of the experiment, an increase in the area of the lymphoid follicle, periarterial and B-dependent zones, an increase in the number of immunoblasts and reproduction centers was registered. By the 10th day there was a partial restoration of these indicators relative to the control values. On the 21st day of the experiment, a decrease in the growth dynamics of all the morphometric parameters of the spleen was observed. Conclusion. Light desynchronosis induces by the Light Light model leads to the development of the pathology of the immune system with an extensive shift of all measurable indicators. Key words: morphofunctional state of the spleen, morphometric criteria, light desynchronosis, immunity.

AttachmentSize
2018_3-1_533-536.pdf339.44 KB

The role of skeletal tissue remodeling markers in the patho-genesis of implant-associated inflammation after primary knee arthroplasty

Year: 2018, volume 14 Issue: №3 Pages: 515-518
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Galashina Е.А., Bondarenko A.S., Ulyanov V.Yu., Klimov S.S.
Organization: Saratov State Medical University
Summary:

Aim: to reveal certain mechanisms of the pathogenesis of implant-associated inflammation by the level of resorption and bone tissue genesis markers in patients who underwent primary knee arthroplasty. Material and Methods. Main group consisted of 40 patients with implant-associated inflammation; first comparison group — of 20 patients with primary aseptic loosening of knee joint implant components; second comparison group — of 20 patients who underwent primary knee arthroplasty without complications in post-operative period; control group — of 20 conventionally healthy individuals. The levels of soluble receptor activator of nuclear factor kappa-B ligand and bone morphogenetic protein-2were defined in blood serum of all subjects by ELISA. Results. In patients of main group we observed more pronounced increase of soluble receptor activator of nuclear factor kappa-B ligand content and significant decrease of bone morphogenetic protein-2 content in blood serum; patients of first comparison group demonstrated activation of soluble receptor activator of nuclear factor kappa-B ligand and decreased levels of bone morphogenetic protein-2 in blood serum; patients of second comparison group did not demonstrate any changes in the studied indexes. Conclusion. The activation of soluble receptor activator of nuclear factor kappa-B ligand and decreased activity of bone morphogenetic protein-2 have leading role in the pathogenesis of implant-associated inflammation.

AttachmentSize
2018_3-1_515-518.pdf257.51 KB

The assessment system of the grade of dysplastic changes in hip joint of children of early age

Year: 2018, volume 14 Issue: №3 Pages: 505-511
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Bakhteeva N.Kh., Anisimova Е.А., Zotkin V.V., Anisimov D.l.
Organization: Saratov State Medical University
Summary:

 Aim: to analyze the method of choice of treatment for children aged 1-3 yrs. with hip joint dysplasia with respect to the complex of pathological changes by the elaboration of CAD programs. Material and Methods. We defined the grade of dysplastic changes in joint components of 82 children with hip joint dysplasia (113 joints) aged 1-3 yrs by CAD program. Results. The grade of dysplastic changes in hip joint (mild — I, moderate — II, severe — III) was identified with the elaborated program and the treatment was administered. We identified 28 children (33 joints) to have mild (I) dysplasia grade, moderate (II) 31 children (42 joints) and severe (III) 23 (38 joints). Mild dysplasia grade (I) corresponded to the score from 5 to 13, and to the option of conservative treatment with dynamic follow-up and coxarthritis prevention, moderate (II) — to the score from 14 to 26 and the option of intertrochanteric detorsion varus corrective osteotomy, severe (III) — to the score from 27 to 39 and the option of pelvis osteotomy and intertrochanteric detorsion varus corrective osteotomy. Conclusion. The treatment of patients with hip dysplasia depends on the grade of dysplastic changes. The elaborated program allows effectively define dysplasia grade and choose treatment method for the patients.

The role of microbial associations in the development of implant-associated infection after primary total knee replacement

Year: 2018, volume 14 Issue: №3 Pages: 492-497
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Babushkina I.V., Bondarenko A.S., Mamonova I.A., Shpinyak S.P., Ulyanov V.Yu.
Organization: Saratov State Medical University
Summary:

Aim: to study the role of microbial associations in the etiology of implant-associated infection, the peculiarities of associates antibiotic resistance, to propose informative methods for the microbiological diagnostics of mixed infections. Material and Methods. The biological samples from 488 patients with infectious complications after total knee replacement were studied. Microorganisms were isolated and identified using a BD BBL™ Crystal™ AutoReader analyzer and Crystal™ Enteric/ Nonfermenter ID Kit, Crystal™Gram-Positive ID Kit panels. Results. Polyetiological infectious complications comprise up to 21.4-24.8% out of the total number of implant-associated infection cases; microbial associations have broad microbial spectrum and various component structure. Specific gravity of clinically significant microorganisms — methicillin-resistant Staphylococcus aureus, polyresistant enterobacteria and nonfermentative Gram- negative bacteria is statistically higher (p<0.05) among the associates (38.2, 25.2, 64.3 and 72.8% respectively) than in monocultures (18.2, 11.8, 47.5 and 58.3% respectively). Microbiological methods should be modified in order to verify polyetiological implant-associated infection. Conclusion. The organization of microbiological monitoring of polyetiologi-cal implant-associated infections with detailed study of microbial associations structure, the monitoring of associates antibiotic resistance is necessary to optimize the diagnostics and causal treatment of this pathology.

AttachmentSize
2018_3-1_492-497.pdf372.67 KB

On the issue of surgical reconstruction in complicated aggressive hemangiomas of sacrolumbar transitional spine

Year: 2018, volume 14 Issue: №3 Pages: 487-492
Heading: Traumatology and Orthopedics Article type: Author's opinion
Authors: Arsenievich V.B., Zaretskov V.V., Likhachev S.V., Stepukhovich S.V., Mizyurov S.A., Sadchikov D.D.
Organization: Saratov State Medical University
Summary:

We presented surgical results of complicated aggressive hemangioma treatment in transitional sacrolumbar spine. It has been stated that individual peculiarities of decompressive stabilizing surgery depend on the volume of vertebral lesions and their results improve in the combination with presurgical X-ray therapy.

AttachmentSize
2018_3-1_487-492.pdf878.8 KB

The Department of Hospital Therapy of Medical faculty as a basis for the new departments organisation and teaching staff training

Year: 2018, volume 14 Issue: №3 Pages: 473-475
Heading: Scientific schools and memorable dates Article type: Short message
Authors: Yudanova L.S., Rebrov А.Р.
Organization: Saratov State Medical University
Summary:

The article represents the history of the Hospital Therapy Department at the Saratov State Medical University served as a basis for new departments' organization. The stages of its development are highlighted.

AttachmentSize
2018_3_473-475.pdf233.94 KB

Professor Zakharova Galina Nikolaevna (to the 100th teacher's birth anniversary)

Year: 2018, volume 14 Issue: №3 Pages: 470-472
Heading: Scientific schools and memorable dates Article type: Short message
Authors: Tsarev О.А.
Organization: Saratov State Medical University
Summary:

The article states the biographical information about Professor G. N. Zakharova, describing her academic contribution into the development of surgery, health care organization and training of academic staff of Saratov Medical Institute.

AttachmentSize
2018_3_470-472.pdf369.54 KB

Professor I.Ya. Livshits and his contribution to the development of national neurosurgery

Year: 2018, volume 14 Issue: №3 Pages: 466-469
Heading: Scientific schools and memorable dates Article type: Short message
Authors: Ulyanov V.Yu., Ninel V.G., Norkin I.A., Grishin S.Ye., Bazhanov S.P., Fedonnikov A.S., Chibrikov G.l., Puchinyan D.M.
Organization: Saratov Medical University "Reaviz", Saratov Socio-Economic Institute of Plekhanov Russian University of Economics, Saratov State Medical University
Summary:

The article traces the professional path of Professor Lev Yakovlevich Livshits, assesses his scientific contribution to the development of national neurosurgery. The concept of minimally invasive surgical treatment of trigeminal nerve neuralgia, developed by L. Ya. Livshits, allowed developing an original method of puncture surgical treatment of pain syndrome by directed hydrothermal destruction of the sensitive trigeminal root. The concept of "growing radicalism" created by Professor L. Ya. Livshits allowed his students elaborating algorithms for treating severe chronic pain syndromes of any localization and etiology.

AttachmentSize
2018_3_466-469.pdf449.07 KB

Professor Natalya Grigoryevna Astafyeva (to the birth anniversary)

Year: 2018, volume 14 Issue: №3 Pages: 464-465
Heading: anniversary Article type: Short message
Authors: Erugina М.V., Abyzova N.V., Zavyalov A.I.
Organization: Saratov State Medical University
Summary:

The article is devoted to the 75th birth anniversary of the Honoured Doctor of the Russian Federation Professor Natalya Grigoryevna Astafyeva.

AttachmentSize
2018_3_464-465.pdf454.6 KB

Modern approaches to the work of student scientific society at the Department of Hospital Therapy of Saratov State Medical University n.a. V.I. Razumovsky

Summary:

The article describes the perspective forms of the student scientific society sessions. Interdepartmental and inter-university conferences open new opportunities for a comprehensive interdisciplinary approach to a particular scientific problem, broadening the knowledge horizon and facilitating the acquisition of the students' discussion and speech experience. Intellectual game as one of the new active forms of the student scientific society sessions was developed at the Department of Hospital Therapy in order to increase the interest to the discipline "Internal Diseases" and involve new students in the scientific activity of the department.

AttachmentSize
2018_3_461-463.pdf232.66 KB