Saratov JOURNAL of Medical and Scientific Research

Saratov State Medical University

www.sgmu.ru

Clinical case of the manifestation of Parkinson's disease in a patient with neuro-leptic-induced parkinsonism

Year: 2019, volume 15 Issue: №1 Pages: 199-202
Heading: Neurology Article type: Case report
Authors: Yudina V.V., Makarov N.S., Yudina G.K.
Organization: Saratov State Medical University
Summary:

The article presents data on the mechanisms of development of drug-induced parkinsonism in patients taking neu-roleptic drugs, as well as on specifics of the development of Parkinson's disease in these patients. A clinical case of Parkinson's disease development in a patient with drug-induced parkinsonism who has been taken antipsychotics for a long time is described.

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Carotid arteries ultrasound screening in asymptomatic patients

Year: 2019, volume 15 Issue: №1 Pages: 190-199
Heading: Neurology Article type: Original article
Authors: Shchanitsyn I.N., Shvarts E.Yu., Ishmukhametova R.A., Vozdeeva A.S.
Organization: Saratov State Medical University
Summary:

Objective: to reveal the most important predictors of carotid artery stenosis in ambulatory patients of Saratov and Saratov Region with the help of multivariate analysis and to define an ideal patient for ultrasound screening. Material and Methods. In 2014-2018 off-site consultations and ultrasound screening were performed for asymptomatic patients with suspected carotid artery disease in outpatient clinics of Saratov and Saratov Region. Those patients were referred for screening by neurologists and general practitioners. The study used 470 medical charts. The multivariate regression analysis was performed to identify independent predictors of carotid artery stenosis (>50%). Results. The >30% carotid artery stenosis was detected in 24.5% (115/470) of participants, >50% stenosis — in 10.2% (48/470) of participants, >70% stenosis — in 2.9% (14/470) of participants. The multivariate analysis revealed that the odds of finding >50% stenosis in patients chosen by neurologists and general physicians for screening was significantly higher in the presence of following factors: age older then 72, male sex, acute cerebrovascular event more than 6 months ago, atherosclerosis in arteries of lower extremities, episodes of speech disorder. The point scale for risk assessment has been created. In the absence of prognostic factors the absolute risk of >50% stenosis was only 3%. In the presence of 1 point it was 16% and more than 50% in the presence of 4 points. Conclusion. The analysis we conducted allowed to specify major predictors of atherosclerosis in patients followed in outpatient clinics of Saratov and Saratov Region and to create the patient model which allows to optimize selection for ultrasound screening.

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Types of cephalalgia syndrome observed in medical students of Saratov State Medical University

Year: 2019, volume 15 Issue: №1 Pages: 177-179
Heading: Neurology Article type: Original article
Authors: Salina Е.А., Parsamyan R.R., Kuznetsova Е.В., Sholomov I.I., Uzhakhov A.M., Shichanina E.K.
Organization: Saratov State Medical University
Summary:

Purpose: to study the prevalence and clinical features of headache among medical students. Material and Methods. 160 students from the medical faculty on their 3rd and 6th years of education were surveyed. The type of headache was determined according to the International Classification of Headache (version 3, 2018). Neuropsychological status of students with tension headaches was studied with use of Schulte test, digital character substitution test, hospital anxiety and depression scale (HADS), test for determining sleepiness and sleep quality, tests for semantic and phonetic activity and memory. Statistical analysis was performed using MS Excel 2010 Results. The most common type of headache among medical students was primary headache, namely tension headache (78.2%). Migraine without aura (20.5%) and cluster headache (1.3%) were less common. Changes in the neuropsychological status were revealed in students suffering from tension headache. Conclusion. A study conducted among medical students showed a high prevalence of primary headache with a predominance of tension headache combined with anxiety and sleep disorders.

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Contribution of Saratov school of dermatology to the study of rare and chronic dermatoses in the 20-30s of the XX century

Year: 2019, volume 15 Issue: №1 Pages: 136-140
Heading: Scientific schools and memorable dates Article type: Short message
Authors: Yakupov IA, Zavyalov Al, Utz SR, Morrison AV, Mizinov DS, Kryukov YuYu.
Organization: Moscow Scientific and Practical Center of Dermatology, Venereology and Cosmetology of Moscow City Health Department, Saratov State Medical University
Summary:

The article is devoted to the scientific and practical contribution of the staff of the clinic of skin and venereal diseases of the Saratov Medical Institute in the study of etiology, pathogenesisand development of modern methods of diagnosis and treatment of rare and chronic skin diseases in the first half of the twentieth century.

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The activity of phthisiology service of the Saratov region during the Great Patriotic War and the first post-war years

Year: 2019, volume 15 Issue: №1 Pages: 132-136
Heading: Scientific schools and memorable dates Article type: Short message
Authors: Chulochnikov А.А.
Organization: Saratov State Medical University
Summary:

The article presents a brief overview of the tuberculosis service's activities, of epidemiological situation in the Saratov region during the Great Patriotic war, and of contribution of advanced tuberculosis evacuation hospitals in reducing the number of tuberculosis cases among military personnel and civilian population in the Saratov region.

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Department of Microbiology of Saratov State Medical University name after V. I. Razumovsky: the origins and the history of development (1918-2018)

Year: 2019, volume 15 Issue: №1 Pages: 127-131
Heading: Scientific schools and memorable dates Article type: Short message
Authors: Mikerov A..N, Raykova S.V., Shvidenko I.G., Khodakova N.G., Soboleva E.F., Shapoval O.G., Allyanova M.S., Kutyrev V.V.
Organization: Saratov State Medical University
Summary:

Department of Microbiology, Virology and Immunology is one of the oldest departments of Saratov State Medical University n.a. V. I. Razumovsky. It has the rich historical experience in the organizing of studies and professional activities of students, which is an integral part in training and education of a modern doctor.

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Professor VitaliyViktorovich Morrison (to the birth anniversary)

Year: 2019, volume 15 Issue: №1 Pages: 124-126
Heading: anniversary Article type: Short message
Authors: Chesnokova N.P., Zavyalov A.l., Afanasyeva G.A.
Organization: Saratov State Medical University
Summary:

The article is devoted to the 75th birth anniversary of Vitaliy Viktorovich Morrison, Professor and Merited Worker of Higher Education of the Russian Federation. Keywords: V.V. Morrison, anniversary.

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Active learning strategy in teaching Nursing discipline at the faculty of General Medicine

Year: 2019, volume 15 Issue: №1 Pages: 119-123
Heading: Pedagogics and Education Article type: Short message
Authors: Tainkin А.А.
Organization: Saratov State Medical University
Summary:

The article presents the author's methods of applying business games and working in small groups in the class on the discipline Nursing. The use of active forms of education will help increase the effectiveness of the educational process.

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Features of angiogenesis in skin tissue regeneration

Year: 2019, volume 15 Issue: №1 Pages: 104-107
Heading: Physiology and Pathophysiology Article type: Review
Authors: Pronina Е.А., Stepanova T.V., Kiriyazi T.S., Maslyakov V.V., Ivanov A.N.
Organization: Saratov Medical University "Reaviz", Saratov State Medical University, Saratov State Technical University n.a. Yu.A. Gagarin
Summary:

Restoration and regeneration of tissues are complex processes involving a large number of signaling mechanisms. In this study possible mechanisms of angiogenesis during tissue regeneration are presented. One of these mechanisms is the creation of a new capillary layer by angiogenesis. Previously it was believed that high and rapid levels of capillary growth are necessary for optimal healing of tissues. But several studies have demonstrated that a period of vascular regression occurs after the growth of blood vessels in a wound, and the number of the newly formed vessels decreases until the number of the blood vessels is equal to the density of the vascular network in the intact tissue. Reduced inflammation and angiogenesis are features of optimal healing.

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Comparative characteristics of microcirculatory changes in white rats during subcutaneous implantation tests of polycaprolactone scaffolds containing vaterite and hydroxyapatite

Year: 2019, volume 15 Issue: №1 Pages: 98-103
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Ivanov A.N., Kurtukova М.О., Chibrikova Yu.A., Kustodov S.V., Tyapkina D.A., Bugaeva I.O., Norkin IA.
Organization: Saratov State Medical University
Summary:

Objective: comparative evaluation of skin microcirculatory functional changes over the implantation area of polycap-rolactone scaffolds with mineral carriers: vaterite and hydroxyapatite. Material and Methods. The experimental study was performed on 43 rats divided into three groups: two test groups and one negative control group. Polycaprolactone PCL-scaffolds containing ovalbumine and of no biocompatibility were implanted into the rats of negative control group (n=15). The implantation of PCL- scaffolds containing vaterite under their skin was performed on rats of the first test group, and animals of the second test group were implanted with PCL-scaffolds containing hydroxyapatite. The method of laser Doppler flowmetry was used to study the microcirculatory flow. Results. The constant increase in the perfusion index has been observed in the area of non-biocompatibile scaffolds implantation. Thechanges in local skin blood flow modulation have been also detected. The transient character of local microcirculatory responses with total normalization of skin perfusion and its mechanisms has been noticed by the 21st day of the trial following PCL-scaffolds with vaterite and hydroxyapatite implantation. Conclusion. The dynamic monitoring has allowed finding that mineralization of PCL-scaffolds with vaterite as well as hydroxyapatite leads to no prominent changes in skin perfusion at subcutaneous implantation tests on white rats suggesting the biocompatibility of these scaffold types.

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