Saratov JOURNAL of Medical and Scientific Research

Optimization of chronic kidney disease stages in patients with type 2 diabetes mellitus with the program "ChronicKidneyDiseaseDiagnostics"

Year: 2017, volume 13 Issue: №3 Pages: 484-488
Heading: Internal Diseases Article type: Original article
Authors: Yarkova N.A., Borovkov А.А., Soloviyanova E.N.
Organization: N. Novgorod State Medical Academy
Summary:

Objective: to evaluate the practical possibility of automated calculation of glomerular filtration rate (GFR) in patients with type 2 diabetes mellitus (DM) on the basis of the developed computer program «Chronic_Kidney_Disease_Di-agnostics». Material and Methods. The study included 233 patients (78 men and 155 women) with type 2 diabetes who were hospitalized in the Neuroendocrinological Department of Nizhny Novgorod Regional Clinical Hospital n.a. O. N. Semashko during the period from 2013 to 2016. The average age of patients was 57.75 years [52; 64]. According to the history the mean duration of type 2 diabetes was of 5.3 years [0.3; 8.0]. The average level of glycosylated hemoglobin (HbA1c) was 9.53% [7.0; 10.2]. All patients underwent clinical and laboratory an3 instrumental studies. The data obtained were entered into the program «Chronic_Kidney_Disease_Diagnostics» (authors: N.A. Yarkova, N.N. Borovkov, D.A. Terekhova). Statistical analysis of the results of research carried out by Statistica 7.0. Results. According to the study in patients with type 2 diabetes, chronic kidney disease has been identified in the pre-clinical stages C2 and C1 (56.2 and 25.8%, respectively). Conclusion. The program «Chronic_Kidney_Disease_Diagnostics» is intended for nephrologists, endocrinologists and therapists. It allows specialists to diagnose kidney CKD in patients in the therapeutic profile of the early preclinical stage. It is designed for quick calculation of glomerular filtration rate.

Bibliography:
1. Shestakova MV. Diabetes mellitus and chronic kidney disease: modern diagnostics and treatment. Herald of the Russian Academy of Medical Sciences 2012; (1): 45-49
2. Maslova OV, Suntsov Yul, Shestakova MV, et al. The prevalence of kidney damage in type 1 and type 2 diabetes in the Russian Federation. Diabetes mellitus 2009; (4): 48-51
3. National Kidney Foundation. KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Diabetes and Chronic Kidney Disease. Am J Kidney Dis 2007; 49 (Suppl. 2): 1-180
4. National Kidney Foundation: K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 2002; 39: 1-286
5. Dedov II, Shestakova MV, eds. Standards of specialized diabetes care (7th edition). Diabetes mellitus 2015; (1S): 1-121
6. Lebedeva NO, Vikulova ОК. Markers of preclinical diagnosis of diabetic nephropathy in patients with type 1 diabetes mellitus. Diabetes mellitus 2012; (2): 38-45
7. Yarkova NA, Borovkov NN, Zanozina OV, Nosov VP Cystatin С in the diagnosis of chronic kidney disease in patients with type 2 diabetes mellitus. Modern technologies in medicine 2013; 5 (4): 89-93
8. Chudleigh RA, Ollerton RL, Dunseath G, et al. Use of cystatin C-based estimations of glomerular filtration rate in patients with type 2 diabetes. Diabetologia 2009; 52:1274-1278
9. Cederholm J, Eliasson B, etal. For the steering committee of the Swedish National Diabetes Register. Microalbuminuria and risk factors in type 1 and type 2 diabetic patients. Diabetes Research and Clinical Practice 2005; 67: 258-266
10. Parving H-H, Lewis JB, et al. DEMAND investigators. Prevalence and risk factors for microalbuminuria in a referred cohort of type II diabetic patients: a global prespective. Kidney Int 2006; 69 (11): 2057-2063
11. Jermendy G, Ruggenenti P. Preventing microalbuminuria in patients with type 2 diabetes. Diabetes/ Metabolism 2007; 23 (2): 100-110
12. Pierrat A, Gravier E, Saunders C, et al. Predicting GFR in children and adults: a comparison of the Cockcroft-Gault, Schwartz and Modification of Diet in Renal Disease formulas. Kidney Int 2003; 64: 1425-1436
13. Vervoort G, Willems HL, Wetzels JF. Assessment of glomerular filtration rate in healthy subjects and and normoalbuminuric diabetic patients: validity of a new (MDRD) prediction equation. Nephrol Dial Transplant 2002; 17: 1909-1913
14. The Diabetes Control and Complications Research Group: Effect of intensive therapy on the development and progression of diabetic nephropathy in the Diabetes control and Complications Trial. Kidney Int 1995; 47: 1703-1720.

AttachmentSize
2017_03_484-488.pdf429.53 KB

No votes yet