Efects of combined treatment for non-infectious uveitis with macular edema on cytokine composition of lacrimal fuid
Year: 2019, volume 15 Issue: №2 Pages: 418-422
Heading: Ophtalmology Article type: Original article
Authors: Arbenyeva N.S., Bratko V.I., Poveshchenko O.V., Trunov A.N., Chernykh V.V.
Organization: Federal Research Center for Fundamental and Translational Medicine of the Siberian Branch of the Russian Academy of Sciences, S. Fedorov Eye Microsurgery Federal State Institution, Novosibirsk Branch, The Research Institute of Clinical and Experimental Lymphology — a Branch of the FFederal Research Center for the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences
Heading: Ophtalmology Article type: Original article
Authors: Arbenyeva N.S., Bratko V.I., Poveshchenko O.V., Trunov A.N., Chernykh V.V.
Organization: Federal Research Center for Fundamental and Translational Medicine of the Siberian Branch of the Russian Academy of Sciences, S. Fedorov Eye Microsurgery Federal State Institution, Novosibirsk Branch, The Research Institute of Clinical and Experimental Lymphology — a Branch of the FFederal Research Center for the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences
Summary:
Purpose: to study the efects of combined treatment for non-infectious uveitis with macular edema using platelet autoplasmin to estimate the cytokine content in lacrimal fuid. Material and Methods. 120 people aged 18 to 50 years with non-infectious uveitis and macular edema were examined: 46 men, 74 women. The patients were divided into 2 groups: main group (anti-infammatory treatment and the administration of platelet autoplasma); comparison group (anti-infammatory treatment). Patients underwent standard ophthalmological examination. To assess the activity of local infammatory process a study of cytokine content in the lacrimal fuid before and after treatment was conducted. Results. In patients with non- infectious uveitis the use of platelet autoplasma in the treatment of patients assigned to the main group lead to a statistically signifcant increase in the concentrations of IL-4, IL-6, IL-8, IL-17A in the lacrimal fuid. A statistically signifcant decrease in the concentrations of proinfammatory cytokines was observed when auto-plasma was used. Conclusion. The use of platelet autoplasma in the treatment of patients with non-infectious uveitis with macular edema is pathogenetically justifed, as it is associated with a pronounced decrease in the activity of the immuno-infammatory process, which is confrmed by the
Bibliography:
1 Dubinina TV, Demina AB, Erdes ShV. HLA-27-associated uveitis: epidemiology, clinical picture and complications Rheumatology Science and Practic. Rheumatology Science and Practic 2014; 52 (3): 304–10
2 Drozdova YeA. The classifcation and epidemiology of uveitis. RMJ Clinical ophthalmology 2016; (3): 155–9
3 Krakhmaleva DA, Pivin YeA, Trufanov SV, et al. Modern trends in the treatment of uveitis. Ophthalmology 2017; 14 (2): 113–9
4 Chernykh VV, Arbenyeva NS, Shvayuk AP, et al. Cytokine imbalance in the tear fuid in autoimmune uveitis. Allergology and Immunology 2013; 14 (2): 147
5 Trunov AN, Arbenyeva NS, Shvayuk AP, et al. Imbalance of cytokines in the lacrimal fuid of patients with autoimmune uveitis. Vestnik of the Orenburg State University 2013; 153 (4): 270–4
6 Yadykina YeV. Uveitis in juvenile idiopathic arthritis: risk factors, clinical features and prognosis: PhD abstract. Chelyabinsk, 2016; 12 p.
7 Kolechenkova IV. Clinical and immunological aspects in the treatment of uveitis in children with the use of transcutaneous led irradiation of the blood: PhD abstract. Moscow, 2014; 15 p.
8 Lykov AP, Surovtseva MA, Poveshchenko OV, et al. Comparative efects of platelet-rich plasma, platelet lysate,
and fetal calf serum on mesenchymal stem cells. Herald of Russian Academy of Medical Sciences 2018; 73 (1): 40–8
| Attachment | Size |
|---|---|
| 2019_02-1_418-422.pdf | 303.89 KB |
Русский
English