Саратовский научно-медицинский ЖУРНАЛ

биомаркеры опухолеассоциированные макрофаги

Prospects of modern methods of diagnosis of renal cancer

Год: 2017, том 13 Номер: №1 Страницы: 068-072
Рубрика: Урология Тип статьи: Обзор
Авторы: Zakharova N.B., Komiagina Yu.M., Ponukalin A.N., Nickolsky Yu.Ye., Korolev A.Yu.
Организация: ФГБОУ ВО Саратовский ГМУ им. В.И. Разумовского Минздрава России
Резюме:

In the researches of recent years it is shown that the cancer of kidneys has been developed against chronic inflammatory process which leads to decrease the activity of a differentiation by the epithelial cells and to strengthening of their proliferation. Further development of a cancer of kidneys is connected with participation of a large number of cytokine and growth factors. Thus tumor cells constantly interact with immune system. These processes lead to tumor associated macrophages which are locally suppressing the antineoplastic immune answer and controlling tumoral angiogenesis to emergence. Now along with a big group of molecular and genetic markers possibility of use of diagnostic and predictive indicators for the effective and personalized treatment of patients with renal cancer the research of tumor associated macrophages and an expression of various proangiogenic factors of an angiogenesis have been considered.

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