Saratov JOURNAL of Medical and Scientific Research

endotoxin

The role of infectious stimulus in the initiation and immune inflammation in psoriasis

Year: 2014, volume 10 Issue: №3 Pages: 530-537
Heading: Skin Diseases Article type: Review
Authors: Slesarenko N.A., Utz S.R., Kulaev K.A., Resnikova M.A., Panina L.V., Popova O.V.
Organization: Saratov State Medical University
Summary:

Psoriasis is a common skin disease in which the development of the decisive role played by genetic and environmental factors. Many of the candidate genes linked with psoriasis, are directly related to acquired or congenital defects of the immune system, epithelial barrier permeability of the intestinal wall, and the keratinocyte membrain. Formation of an immune response to Th-1 type high expression and activity of antimicrobial peptides like state at their potential infection. This review discusses the possible immune mechanisms are involved in the relationship between infection and disease process in psoriatic skin. We survey the literature and discuss the suitability of infection factors in treatment modality for psoriasis.

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Microbial translocation and systemic inflammatory response in HIV-infection

Year: 2013, volume 9 Issue: №3 Pages: 508-512
Heading: Infectious Diseases Article type: Original article
Authors: Khasanova G.K., Bikkinina О.I., Anokhin V.A.
Organization: Kazan State Medical University
Summary:

The purpose of the research was detection of markers of systemic inflammatory response syndrome together with levels of markers of gram-negative endotoxinemia in HIV-patients for evaluation of role of endotoxin in immune system hyperactivation and progression of disease. Material and methods. Evaluation of levels of endotoxin, sCD14, interleu-kin 1(3, TNF-a and C-reactive protein was done in 232 HIV-positive patients. LAL-test, ELISA and biochemical tests were used. Results. The statistically significant increase of levels of all markers of systemic inflammatory response which were investigated was detected in the group of HIV-positive patients, comparing to group of healthy individuals. Direct correlation of sCD14 level with most of markers of systemic inflammatory response was found. Increased level of sCD14 was associated with more prominent clinical and laboratory signs of immunosupression. Conclusion. These results confirm a role of endotoxin which is a marker of microbial translocation and highly active biological substance in pathogenesis of immune system hyperactivation and progression of HIV-infection.

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2013-03_508-512.pdf308.67 KB