Saratov JOURNAL of Medical and Scientific Research

St. Petersburg Institute of Bioregulation and Gerontology

The role of epithelial cells proliferation and apoptosis disturbances in pathogenesis of inflammatory diseases of parodentium accompanied by gastroesophageal reflux disease

Year: 2013, volume 9 Issue: №3 Pages: 449-453
Heading: Stomatology Article type: Original article
Authors: Osipova J.L., Bulkina N.V., Osadchuk М.А., Kvetnoy I.M.
Organization: First Moscow State Medical University n.a. I.M. Sechenov, Saratov State Medical University, St. Petersburg Institute of Bioregulation and Gerontology
Summary:

The aim of the research was the study of the cell proliferation indices of the gum epithelial cells in patients with parodentium inflammatory diseases accompanied by gastroesophageal reflux disease (GERD). Material and methods. 160 patients were examined, 60 patients with parodentium inflammatory diseases accompanied by NEGERD, 40 patients with parodentium inflammatory diseases accompanied by GERD. The comparison groups consisted of 40 patients with diseases of parodentium without esophagus pathology and 20 healthy persons. Results. On the basis of the conducted clinical-endoscopic, immune-histological and morphological examinations it was established that gingivitis and periodontitis are successive stages of disturbance of the cellular homeostasis of gum epithelial cells. Conclusion. The enhancement of the processes of proliferation and apoptosis promotes the progression of the structural alterations in the tissues of parodentium and oesophagus and may serve as additional diagnostic and prognostic criteria of the diseases of parodentium accompanied by GERD.

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