Saratov JOURNAL of Medical and Scientific Research

lipid peroxidation

Siofor influence on the process of lipid peroxidation and antioxidant status at patients with metabolic syndrome

Year: 2013, volume 9 Issue: №4 Pages: 744-748
Heading: Endocrinology Article type: Original article
Authors: Chernysheva E.N., Panova T.N.
Organization: Astrakhan State Medical University
Summary:

The Purpose of the work is to research siofor influence (metformin) on the activity of the process of lipid peroxidation and antioxidant activity of blood serum at patients with metabolic syndrome. Material and Methods. 62 patients with metabolic syndrome at the age from 30 till 60 were examined and treated by siofor (1700 mg per day) during a year. The process of lipid peroxidation was studied due to the level of lipid hydroperoxide of blood serum. Antioxidant capacity was based on the antioxidant reaction in the blood serum with definite number of exogenic hydrogen dioxide (mkmole/l) with the method of ELISA. Results. Intensification of process of lipid peroxidation has been observed at patients with metabolic syndrome —the level of lipid hydroperoxide of blood serum has been 2,9 (1,94; 3,9) mkM, antioxidant activity of blood serum has been decreased — 276,4 (239,0; 379,9) mkmole/l. In 12 months of siofor intake hydroperoxide level has been decreased till 1,1 (0,8; 1,9) mkM, but antioxidant activity has been increased and amounted 320,0 (278,9; 334,3) mkmole/l. Conclusion. Siofor has been proved to be a highly effective medicine for correction of process of lipid peroxidation and for improvement of antioxidant activity of blood serum at patients with metabolic syndrome.

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Programmed cell death and processes of lipid peroxidation in metabolic syndrome

Year: 2013, volume 9 Issue: №2 Pages: 277-281
Heading: Internal Diseases Article type: Original article
Authors: Chernysheva E.N., Panova T.N
Organization: Astrakhan State Medical University
Summary:

The purpose: To study possible interconnection between programmed cell death and the processes of lipid peroxidation in the patients with metabolic syndrome. Material and Methods: 270 patients with metabolic syndrome at the age of 30 till 60 (162 men and 108 women) have been examined. MC diagnostic was based on the criteria recommended by experts of society of cardiologists of Russia (2009). Lipid peroxidation was estimated according to the content of hydroperoxide (mkM), the programmed cell death process was studied with protein p53 concentration determination; high sensitivity C-reactive protein content in blood serum was studied by enzyme multiplied immunoassay method (ELISA). Results: In the patients with metabolic syndrome the programmed cell death processes and lipid peroxidation are intensified. High level of lipid hydroperoxide indicates it — 2,89(1,94; 4,1) mkM and protein p53-1,59 (1,361,91) U/ ml in blood serum. Strict direct correlation between lipid peroxidation level and body weight index was defined (r+0,77, p

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