Saratov JOURNAL of Medical and Scientific Research

Saratov State Medical University n.a. V I. Razumovsky, Scientific Research Institute of Fundamental and Clinical Uronephrology

The value of tumor markers in prognos-ing the outcomes of treatment of patients with bladder cancer

Year: 2018, volume 14 Issue: №4 Pages: 661-666
Heading: Urology Article type: Review
Authors: Ponukalin A.N., Zakharova N.B., Skriptsova S.A., Fomkin R.N., Chekhonatskaya M.L.
Organization: Saratov State Medical University n.a. V I. Razumovsky, Scientific Research Institute of Fundamental and Clinical Uronephrology, Saratov State Medical University
Summary:

The review analyzes the recent publications of the results of the use of molecular genetic markers of bladder cancer (RMP) in clinical practice. The prospects of application of a series of molecules determined in tumor tissue, serum, urine in the diagnosis of RMP are presented. One ofthe most promising areas of finding a marker forthe diagnosis and control of treatment of RMP in recent years are the study ofthe proteomic composition of urine.

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Complex diagnostics and treatment potential of deep implant- associated infection of knee joint

Summary:

The review of open access literature on the issues of complex diagnostics and treatment potential of implant-associated infection of the knee joint area was given in the article. We describe clinical signs, the potential of laboratory diagnostics of deep implant-associated infection from the point of view of sensitivity and specificity as well as main methods of surgical treatment of the pathology.

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Direct renin inhibitor aliskiren in surgical treatment of nephrolithiasis

Year: 2013, volume 9 Issue: №1 Pages: 122-127
Heading: Urology Article type: Original article
Authors: A.N., Popkov V.M., Ponukalin A.N., Chekhonatskaya M.L, Zakharova N.B., Berezinets O.L., Inozemtseva N.D.
Organization: Saratov State Medical University, Saratov State Medical University n.a. V I. Razumovsky, Scientific Research Institute of Fundamental and Clinical Uronephrology
Summary:

Research objective: The study investigates the antifibrotic nephroprotective effects of aliskiren on the condition of renal hemodynamics, changes of profibrotic cytokines level and markers of renal damage in patients with nephrolithiasis undergone various types of surgery. Materials and methods: Patients have been divided into 2 groups. The investigations have been performed before the surgery and in a month period. Concentrations of TGF-p, markers of acute renal tubulointerstitial damage — NGAL and p2-microglobulin in urine, levels of ET-1 in serum and indicator of endothelial dysfunction have been determined. Assessment of renal blood flow state by Doppler ultrasonography has been carried out in the same terms. Results: As a result of aliskiren treatment the decrease of mediators of tubulointerstitial damage and nephrofibrosis, significant improvement in renal blood flow in a month period after the surgery have been marked in comparison with the group which had not received nephroprotective therapy. Conclusion: Direct renin inhibitor aliskiren may be used as a means of renal protection therapy in treatment of patients with nephrolithiasis.

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