Saratov JOURNAL of Medical and Scientific Research

malignant growths

Correction of immune disorders in patients with malignant tumors at level of craniovertebral junction and upper cervical spine

Year: 2013, volume 9 Issue: №2 Pages: 295-301
Heading: Oncology Article type: Original article
Authors: Bazhanov S.P., Uljanov V.Yu., Norkin I.A., Gulyaev D.A.
Organization: Russian Scientific Research Institute of Neurosurgery n.a. Professor A. L. Polenov

Objective: To study the cellular and humoral immunity in patients with malignant tumors of the upper cervical spine. Material and methods: The study included 22 patients with malignant tumors of the craniovertebral junction and upper cervical spine. To assess the function of the immune system the methods of population and subpopulation immuno-phenotyping of peripheral blood lymphocytes have been applied. Cytokine parameters and functional status (cytotoxic) activity of NK-cells have been studied using immunofermental methods. The indices have been presented in absolute and relative terms. All the patients have been subjected to the adjuvant therapy. Results: Correction of cellular immunity has led to significant increase in CD3 + (T-lymphocytes) and CD3 + CD8 + (T-killers). Cytokine levels in the groups studied in the dynamics have not been significantly altered. The changes of cytotoxic (functional) activity of NK-cells in the first group after the combined treatment have been considered to be higher than before the treatment. Cytotoxic index of (functional) activity of NK-cells in the second group under the study after the combined treatment has been determined to be lower than before the treatment. Conclusion: It has been found out that the application of complex treatment accompanied by immunotropic therapy may positively influence the immune status.

2013-02_295-301.pdf335.07 KB

Analysis of Cancer Morbidity in Nizhny Novgorod Region for the Period of 10 years and Necessity for Palliative Care Development

Year: 2013, volume 9 Issue: №1 Pages: 9-12
Heading: Health Service Organization Article type: Review
Authors: Vvedenskaya E.S., Kobzeva L.F.
Organization: Nizhny Novgorod Center for AIDS Prophylaxis and Control

The purpose of the article is to present the main indicators of cancer morbidity and mortality in Nizhny Novgorod region in comparison with those in Russia in dynamics for the period of 10 years. The survey outlines the necessity of regional palliative care development. It has been revealed that the organization of specialized palliative care centers on the basis of Oncological Dispensaries, In-patient Departments, Regional Polyclinics and Medical Prophylactic Institutions is of great importance.

2013-01_009-012.pdf550.25 KB