Saratov JOURNAL of Medical and Scientific Research

morphological reaction

Morphological changes of tissues in the zone of implantation of combined hernia prosthesis in the post-operative period

Year: 2017, volume 13 Issue: №3 Pages: 458-461
Heading: Macro- and Micromorphology Article type: Original article
Authors: Kalmin O.V., Nikolsky V.I., Fedorova M.G., Feoktistov Ya.E.
Organization: Penza State University
Summary:

The purpose of this experimental study is to study the patterns of morphological response of the abdominal wall tissues to the implantation of a combined (xenopericardial plate and polyester mesh) hernia prosthesis. Material and Methods. The experiment was carried out on fifteen rabbits of the breed Chinchilla weighing up to 3.5kg. The combined prosthesis was implanted intra — abdominally. The animals were withdrawn from the experiment after 2 weeks, 1 month and 2 months. After the beginning of the study morphological and morphometric assessment of the tissue state in the implantation zone of the prosthesis was carried out. Results. The combined hernia prosthesis when implanted into the anterial abdominal wall causes a rather pronounced inflammatory reaction, progressing within a month after the operation. By the second month of the experiment, signs of inflammation decrease. In this case, active growth of the young connective tissue in the implant from the side of the polyester mesh occurs. Xenopericardial plate, facing the abdominal cavity with a smooth side does not cause the formation of connective tissue, which protects the abdominal cavity from the occurrence of adhesions in the postoperative period. Conclusion. The use of combined hernia prosthesis for implantation into the abdominal wall allows avoiding a number of complications which often occur when using prostheses of other types.

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Morphological changes in bone tissue around titanium implants subjected to micro-arc oxidation in alkaline electrolytes with and without the use of «CollapAn-gel»

Year: 2013, volume 9 Issue: №4 Pages: 624-628
Heading: Macro- and Micromorphology Article type: Original article
Authors: Kalmin O.V., Rozen М.А., Nikishin D.V.
Organization: Penza State University
Summary:

The purpose of the article is to conduct comparative study of the features of reparative processes in the bone during installation of titanium implants with sandblasted exposed microarc subsequent oxidation in alkaline electrolyte using osteoinductive formulation without the use of this preparation. Material and Methods. Histologically examined tissue samples from 24 adult rabbits in the region of titanium implant with osteoinductive formulation and without after 7, 14, 28, 56 and 112 days postoperatively. Results. It has been revealed that the installation of titanium implants subjected to micro-arc oxidation in alkaline electrolytes without the use of osteoinductive preparation leads to a moderate inflammatory response and the processes of bone formation take more time. When using identical implants with osteoinductive preparation «CollapAn-gel» led to a less expressed inflammatory response and a more active process of bone formation. Conclusion. The use of titanium implants subjected to sandblasting followed microarc oxidation in alkaline electrolytes is optimally combined with osteoinductive agents as it provides the best clinical results and highlights shorter time of bone regeneration.

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Morphological changes of tissue in implantation of xenopericardium and polypropylene net after surgical intervention

Year: 2012, volume 8 Issue: №4 Pages: 1008-1012
Heading: Surgery Article type: Original article
Authors: Kalmin O.V., Nikolsky V.I., Fiodorova M.G., Titova Ye.V., Yangurazova Ye.V.
Organization: Penza State University
Summary:

The purpose: Comparative study of rehabilitation processes after implantation of synthetic and biological materials into the tissue of abdominal wall. Materials and Methods: Histological methods have been used to study tissue samples from 15 implantation area of xenopericardial plate and polypropylene net of adult rabbits in 3, 6 and 12 months after the surgery. Results: It has been found out that polypropylene net implantation in the tissue of anterior abdominal wall causes inflammation and growth of connective tissue only around it. Xenopericardial plate implantation is accompanied by lesser inflammation an3 it connects with surrounding connective tissue. Conclusion: It has been revealed that xenopericardium is more likely to use in herniologythan synthetic net. It provides greater mechanical strength of abdominal wall in the later periods after the surgical intervention.

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