Saratov JOURNAL of Medical and Scientific Research

Penza State University

Morphological changes of tissues in the zone of implantation of combined hernia prosthesis in the post-operative period

Year: 2017, volume 13 Issue: №3 Pages: 458-461
Heading: Macro- and Micromorphology Article type: Original article
Authors: Kalmin O.V., Nikolsky V.I., Fedorova M.G., Feoktistov Ya.E.
Organization: Penza State University
Summary:

The purpose of this experimental study is to study the patterns of morphological response of the abdominal wall tissues to the implantation of a combined (xenopericardial plate and polyester mesh) hernia prosthesis. Material and Methods. The experiment was carried out on fifteen rabbits of the breed Chinchilla weighing up to 3.5kg. The combined prosthesis was implanted intra — abdominally. The animals were withdrawn from the experiment after 2 weeks, 1 month and 2 months. After the beginning of the study morphological and morphometric assessment of the tissue state in the implantation zone of the prosthesis was carried out. Results. The combined hernia prosthesis when implanted into the anterial abdominal wall causes a rather pronounced inflammatory reaction, progressing within a month after the operation. By the second month of the experiment, signs of inflammation decrease. In this case, active growth of the young connective tissue in the implant from the side of the polyester mesh occurs. Xenopericardial plate, facing the abdominal cavity with a smooth side does not cause the formation of connective tissue, which protects the abdominal cavity from the occurrence of adhesions in the postoperative period. Conclusion. The use of combined hernia prosthesis for implantation into the abdominal wall allows avoiding a number of complications which often occur when using prostheses of other types.

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Clinical manifestations and forensic medical evaluation of hemothorax

Year: 2017, volume 13 Issue: №2 Pages: 221-224
Heading: Forensic medicine Article type: Original article
Authors: Kupryushin A.S., Efimov А.А., Loginov S.N., Vishnyakova Zh.S., Latynova I.V., Semina M.N., Godukhina E.M.
Organization: Penza State University, Saratov State Medical University
Summary:

Objtctive: to determine the degree of validity of the allocation of traumatic hemothorax as a medical criterion of a qualifying trait in respect of serious harm to health, which is life-threatening. Material and Methods. A retrospective analysis of 130 case histories of the patients of the Department of Thoracic Surgery was carried out at Penza Clinical Hospital n.a. N.N. Burdenko. The sex, age, severity of the patient's condition, the volume of blood in the pleural cavity, complications of hemothorax (GT), the time between trauma and seeking medical help, and other injuries were analyzed. Results. It was found out that among patients with HT men were 4,2 times more than women. HT developed after traumatic exposure to the thorax in patients of both gender groups. Conclusion. The severity of the condition of patients with HT is determined by the volume of blood in the pleural cavity, complications, the presence of concomitant damages, the number of days between receiving an injury and contacting a medical organization. In the formulation of p. 6.1.10 Order No. 194n of the Ministry of Health and Social Development of April 24, 2008, "On the Approval of Medical Criteria for Determining the Severity of Harm to Human Health" we should add the phrase: "...or a severe or medium hemothorax that causes a life threatening condition..." aiming at an objective forensic evaluation of traumatic h e moth о rax.

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Characteristics of cases with poor outcomes of rendering medical care to children in six regions of the Russian Federation

Year: 2017, volume 13 Issue: №1 Pages: 010-013
Heading: Forensic medicine Article type: Original article
Authors: Erofeev S.V., Kupryushin A.S., Efimov А.А., vishnyakova Zh.S., Semina M.N.
Organization: Bureau of Forensic Medical Examination of the Ivanovo Region, Ivanovo State Medical Academy, Penza State University, Saratov State Medical University
Summary:

Objective: to determine the characteristics of the outcome of the improper care for children, established during the commission of forensic examinations. Material and Methods. The material of this study was commission a forensic medical examination of the archives department of complex expertise of the Bureaus of Forensic Medicine of Moscow; the Moscow, Penza, Samara and Ulyanovsk regions, and the Republic of Mordovia, conducted from 1996 to 2006. The method of this study was a statistical database processing using Excel software application package. Results. The article presents the results of the analysis of 279 forensic medical examinations conducted by committees in the Bureaus of Forensic Medical Examination of Moscow; the Moscow, Penza, Samara and Ulyanovsk regions, and the Republic of Mordovia from 1996 to 2006. The examinations were conducted in connection with poor outcomes of rendering medical care to children. Conclusion. The number of conducted examinations correlates with the population of the region. The parents of the children affected by poor treatment mostly demand the medical staff to be prosecuted and more often make legal claims to the quality of emergency medical care; dissatisfaction with the quality of medical care is more often expressed by the parents of children under 3 years old. Legal claims are more often made against obstetricians-gynecologists, pediatricians, surgeons, infectious disease specialists and anesthesiologists-resuscitators. If the conclusion of the forensic medical examination committee on the nature of the pathological process coincides with the final clinical diagnosis, the provided medical care often turns out to be adequate; in cases of inadequate medical care the risks of moderate and grievous bodily harm as well as the patient's death are high.

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Modern issue on the role of microorganisms in the induction and the development of atherosclerosis

Year: 2016, volume 12 Issue: №2 Pages: 113-117
Heading: Macro- and Micromorphology Article type: Review
Authors: Kupryushin AS, Chudaeva DG, Fedorova MG, Latynova IV, Vishnyakova ZhS, Kuprushyna NV, Efimov AA.
Organization: Penza State University
Summary:

More than 70 literature sources are presented and analyzed in the work. Data sources are devoted to the connection between infection and development of atherosclerotic changes. It has been found out that the infection and the presence of pathogenic microorganisms influence the progression of atherosclerosis.

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The structure of thyroid gland in its pathology

Year: 2015, volume 11 Issue: №2 Pages: 113-117
Heading: Macro- and Micromorphology Article type: Original article
Authors: Khayrullin R.M., Kalmin O.V., Kalmin O.O.
Organization: Penza State University
Summary:

Objective: to identify the microscopic features of the structure of the thyroid gland in different forms of its pathology. Materials and Methods. The study is based on the thyroid glands of 199 patients of both sexes aged 21 to 74 years. Results. At the micro-macrofollicular nontoxic goiter was found flattened thyroid epithelium with flattened normochromic nucleus, the small size of cells and nuclei, low nuclear-cytoplasmic index, intrafollicular moderate epithelial proliferation, homogeneous colloid and moderate diffuse lymphoid infiltration. At the micro-macrofollicular toxic goiter detected cubic epithelium with rounded normochromic kernel, smallest size of cells and nuclei, nuclear-cytoplasmic minimum index intrafollicular focal proliferation of the epithelium, colloid mesh boundary with severe vacuolization, focal lymphoid infiltration and hemorrhage. When diffuse toxic goiter detected cubic form cells of medium size with a fairly high nuclear-cytoplasmic index, rounded normochromic kernel, rare intrafollicular epithelial proliferation, homogeneous colloid with an edge vacuolization. With the prevalence of autoimmune thyroiditis was observed flattened epithelium with rounded normochromic nucleus, the small size of cells and nuclei, found the average nuclear-cytoplasmic index, homogeneous colloid and extensive lymphoid infiltration with light propagation centers. Adenoma of the thyroid gland epithelium was found with a cubic cell shape, round hyperchromatic nucleus, the large size of cells and nuclei, high nuclear-cytoplasmic index intrafollicular diffuse proliferation of epithelial and dense colloid. When thyroid cancer found the prevalence of papillary structures with short broad papillae formed polymorphic cells with round hyperchromatic nucleus, there is the largest size of cells and nuclei, nuclear-cytoplasmic maximum index expressed intrafollicular diffuse proliferation of the epithelium. Conclusions. Each form of thyroid disease, along with well-known typical microscopic manifestations is a characteristic regional feature of the microstructure.

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Evaluation of the effectiveness of a resorbable membrane «Bio-Gidein» in combination with chitosan for the treatment of bone defects

Year: 2014, volume 10 Issue: №2 Pages: 239-245
Heading: Macro- and Micromorphology Article type: Original article
Authors: Kalmin O.V., Nikishin D.V., Volodina Yu.M.
Organization: Penza State University
Summary:

Objective: to evaluate the efficiency of a resorbable membrane «Bio-Gide» in combination with chitosan for guided bone regeneration during the degradation under the experimental conditions. Material and Methods. The histological methods provide the study of tissue samples from 6 adult rabbits from artificial mandible through 14, 28 and 42 days after surgery. In group 1 the treatment was carried out without the use of additional materials, by a blood clot. In group 2 closing of the damaged area was produced by xenopericardial plate «Bio-Gide» in combination with chitosan. Results. It has been established that the conduct of bone wound under a blood clot causes inflammatory response on the 14th day after the operation, to the 28th day inflammation disappears and it practically does not appear on the 42nd day. Closure of the bone defect using xenopericardial plate «Bio-Gide» with chitosan causes lesser inflammatory response. In the long-term period after the surgery inflammatory changes in the implantation can not be detected. Conclusion. Xenopericardial plate «Bio-Gide» in combination with chitosan has a positive impact on the recovery process of the bone defect. Neoplasm of bone occurs, the stage of development of cartilage is shortened. At the end of the experiment period xenopericardial plate is not detected indicating the high rate of its biodegradation.

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Mathematical modeling of structural indices of thyroid gland in thyroid pathology

Year: 2014, volume 10 Issue: №1 Pages: 38-44
Heading: Macro- and Micromorphology Article type: Original article
Authors: Kalmin O.V., Kalmin О.О..
Organization: Penza State University
Summary:

Purpose: the complete analysis of the morphological parameters of the thyroid gland in various forms of thyroid pathology by methods of mathematical modeling. Material and Methods. Histologically examined samples of operating thyroid glands of 199 patients of both sexes aged 21 to 74 years, were treated surgically. Experimental data were studied by factorial and discriminant analysis. Results. When the factor analysis of 60 experimental parameters were identified 14 major factors that indicate 14 main trends in the dynamics of the structure of the thyroid gland due to an increase in severity of pathological processes. Discriminant analysis showed that the study of quantitative structure of the thyroid gland there may be cases of erroneous inclusion in the theoretical option groups, however, the study of the entire set of indicators observed a 100% correct distribution of cases by groups of pathology. Conclusion. As a result, the factor of the original system of 60 morphological parameters of thyroid pathology in various forms has been minimized to 14 new uncorrelated parameters (main factors), reflecting changes in the morphology of the basic laws of the pathology of the gland. As a result of the discriminant analysis of morphological parameters of the thyroid gland in different types of its pathology the importance of semi-quantitative parameters of thyroid structure has been revealed.

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Morphological changes in bone tissue around titanium implants subjected to micro-arc oxidation in alkaline electrolytes with and without the use of «CollapAn-gel»

Year: 2013, volume 9 Issue: №4 Pages: 624-628
Heading: Macro- and Micromorphology Article type: Original article
Authors: Kalmin O.V., Rozen М.А., Nikishin D.V.
Organization: Penza State University
Summary:

The purpose of the article is to conduct comparative study of the features of reparative processes in the bone during installation of titanium implants with sandblasted exposed microarc subsequent oxidation in alkaline electrolyte using osteoinductive formulation without the use of this preparation. Material and Methods. Histologically examined tissue samples from 24 adult rabbits in the region of titanium implant with osteoinductive formulation and without after 7, 14, 28, 56 and 112 days postoperatively. Results. It has been revealed that the installation of titanium implants subjected to micro-arc oxidation in alkaline electrolytes without the use of osteoinductive preparation leads to a moderate inflammatory response and the processes of bone formation take more time. When using identical implants with osteoinductive preparation «CollapAn-gel» led to a less expressed inflammatory response and a more active process of bone formation. Conclusion. The use of titanium implants subjected to sandblasting followed microarc oxidation in alkaline electrolytes is optimally combined with osteoinductive agents as it provides the best clinical results and highlights shorter time of bone regeneration.

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Morphological changes of tissue in implantation of xenopericardium and polypropylene net after surgical intervention

Year: 2012, volume 8 Issue: №4 Pages: 1008-1012
Heading: Surgery Article type: Original article
Authors: Kalmin O.V., Nikolsky V.I., Fiodorova M.G., Titova Ye.V., Yangurazova Ye.V.
Organization: Penza State University
Summary:

The purpose: Comparative study of rehabilitation processes after implantation of synthetic and biological materials into the tissue of abdominal wall. Materials and Methods: Histological methods have been used to study tissue samples from 15 implantation area of xenopericardial plate and polypropylene net of adult rabbits in 3, 6 and 12 months after the surgery. Results: It has been found out that polypropylene net implantation in the tissue of anterior abdominal wall causes inflammation and growth of connective tissue only around it. Xenopericardial plate implantation is accompanied by lesser inflammation an3 it connects with surrounding connective tissue. Conclusion: It has been revealed that xenopericardium is more likely to use in herniologythan synthetic net. It provides greater mechanical strength of abdominal wall in the later periods after the surgical intervention.

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