Saratov JOURNAL of Medical and Scientific Research

Lepilin A.V.

Saratov State Medical University n.a. V. I. Razumovsky, Head of Department of Dental and Maxillofacial Surgery, Professor, Doctor of Medical Science

The value of composition and cytokine activity of wound discharge cells in patients with acute odontogenic inflammatory diseases of the maxillofacial region

Year: 2015, volume 11 Issue: №2 Pages: 173-177
Heading: Stomatology Article type: Original article
Authors: Lepilin A.V., Zakharova N.B., Fedotenkova D.A., Tereshkina N.E.
Organization: Saratov State Medical University
Summary:

Purpose: to establish the diagnostic value of the immune cells composition and cytokine activity of the cells in wound discharge from patients with acute odontogenic inflammatory diseases of maxillofacial region. Materials and methods. A total of 31 patients with acute odontogenic inflammatory diseases of maxillofacial region were examined. The number of immune cells and pro-inflammatory cytokines content (IL1(3, MCP1, IL6, IL8, TNFa) in the wound discharge were determined. Results. It has been established that depending on the severity of the inflammatory process in maxillofacial region the immune cells composition and levels of pro-inflammatory cytokines are changing. Conclusion. Determination of the immune cells composition and level of cytokines in the wound discharge can be used for estimation of the character and severity of acute odontogenic inflammatory processes in the maxillofacial region.

AttachmentSize
2015_02_173-177.pdf535.41 KB

The use of professional oral hygiene in orthodontic treatment on the results of studies of gingival fluid biomarkers

Year: 2015, volume 11 Issue: №2 Pages: 168-173
Heading: Stomatology Article type: Original article
Authors: Zakharova N.B., Lepilin A.V., Vorobjev D.V., Erokina N.L., Bakhteeva G.R.
Organization: Medical Clinic "Medstom", Saratov State Medical University
Summary:

The aim: to prove the necessity of professional oral hygiene before the fixation of permanent orthodontic equipment in individuals with dental and facial anomalies based on the study of biomarkers of gingival fluid. Materials and Methods: Clinical, cytological examination and gingival fluid test on cytokine levels in 80 patients. Results: In patients with dentofacial anomalies observed decline in hygiene index, and increase the content of gingival fluid neutrophils and degenerative epithelial cells. It is accompanied by an increase in the concentration of the main group of pro-inflammatory and osteogenic cytokines, growth factors. Conclusion: Preliminary conducting professional oral hygiene to orthodontic treatment in patients with dentofacial anomalies leads to the conservation values of satisfactory hygienic indices of the mouth. In this case, the increase in the content of gingival fluid neutrophils and degenerative epithelial cells, with increased concentrations of the main group of pro-inflammatory and osteogenic cytokines has been defined insignificant.

AttachmentSize
2015_02_168-173.pdf326.53 KB

Modern technologies of local injection anesthesia in dental practice

Year: 2013, volume 9 Issue: №3 Pages: 470-472
Heading: Stomatology Article type: Original article
Authors: Sohov S.Т., Bizyev, A.F., Lepilin A.V.
Organization: Moscow State Medical Stomatological University n.a. A. I. Evdokimov, Saratov State Medical University
Summary:

Objective: To assess the importance of using the new system Quick Sleeper for local anesthesia, to highlight benefits of quick and comfortable anesthesia. Material and Methods. The examination of effectiveness, convenience of this kind of anesthesia has been carried out. Results. All patients, taking part in this examination, confirmed more comfortable condition after this anesthesia than conductor and infiltration methods of anesthesia. The effect of anesthesia is better than after conductor anesthesia. Conclusion. This technology guarantees equal introduction and spread of anesthetic, independently of tissue density, eliminating the risk of carpule breakage.

AttachmentSize
2013-03_470-472.pdf256.88 KB

Scientific fundamentals for the development of dental implants

Year: 2013, volume 9 Issue: №3 Pages: 431-434
Heading: Stomatology Article type: Author's opinion
Authors: Lyasnikov V.N., Lepilin A.V., Protasova N.V.
Organization: Saratov State Technical University, Saratov State Medical University
Summary:

The article deals with topical issues of development, production and application of modern biocompatible materials and coatings based on them to clinical practice. Particular attention is paid to the intraosseous dental implants, which considered to be the most popular and well established methods to address the defects of dentition with partial and fully edentulous state.

AttachmentSize
2013-03_431-434.pdf284.89 KB

Clinical and statistical analysis of traumatic injuries of the maxillofacial region and its complications on materials of the Department of Maxillofacial Surgery from 2008 till 2012

Year: 2013, volume 9 Issue: №3 Pages: 425-428
Heading: Stomatology Article type: Original article
Authors: Lepilin A.V. Bakhteeva G.R., Nozdrachyov V.G., Shikhov M.Y., Ramazanov A.Kh.
Organization: Clinical Hospital № 9, Saratov, Saratov State Medical University
Summary:

Purpose: to study the frequency of occurrence of various traumatic injuries of the maxillofacial region. Material and Methods. The records of patients who were treated in the maxillofacial department, in the period from 2008 to 2012 were studied. Results. The number of patients with traumatic injuries of the maxillofacial region forthe period amounted to 38% of the total number of hospitalized patients. The average age of patients with maxillofacial trauma is 27.5 years.
The ratio of male and female patients during the study period did not change (men 89%, women — 11 %). Single fractures that do not require surgical treatment were dominated. Operating activities during the study period of fracture increased. For 5 years, the number of complications of traumatic injuries remained the same. Conclusion. Statistical analysis of traumatic injuries of the maxillofacial region shows that the average age of the patients decreased by almost 5 years, reduced average hospital stay. Most of the patients were admitted to the profile department in the early period (up to 3 days after preparation), but 21.6% of the patients were received only with the development of complications. The article concludes that there is a need to find new methods of diagnosis, treatment and prevention of complications of traumatic injuries.

AttachmentSize
2013-03_425-428.pdf256.05 KB

The possibility of different CAD systems in the construction of mathematical model of bone tissue

Year: 2013, volume 9 Issue: №3 Pages: 403-405
Heading: Stomatology Article type: Author's opinion
Authors: Ivanov D.V., Lepilin A.V., Smirnov D.A., Dol A.V.
Organization: Saratov State Medical University, Saratov state university
Summary:

Modern methods of diagnosing of maxillary bones in various clinical situations presume a method of computer tomography. In some cases, the treatment planning according to three-dimensional image cannot be performed and the question of creation of the biomechanical model study area arises. Various methods of computer-aided design and three-dimensional modeling are worth while using to achieve the realization of the task.

AttachmentSize
2013-03_403-405.pdf230.83 KB

Urgent problems of improvement of stomatologic aid to patients with locally extended cancer of oral cavity mucus

Year: 2013, volume 9 Issue: №3 Pages: 397-399
Heading: Stomatology Article type: Original article
Authors: Ivanova О.V., Maty akin G.G., Lepilin A.V.
Organization: Saratov State Medical University, Central Clinical Hospital, Moscow, Astrakhan Stomatologic Polyclinic №4
Summary:

Aim of the investigation: to develop the methods of increasing effectiveness of stomatologic accompanying therapy at all stages of locally extended cancer of oral cavity mucus. Material and methods: The results of treatment of 563 patients with locally extended cancer of oral cavity mucus have been analyzed. Among them 205 patients with the proved diagnosis were examined by a dentist. A special committee developed a plan of accompanying therapy where a stomatologic treatment was significant. Other 358 patients were not examined by a dentist before therapy. Re-sults. Planning of stomatologic aid and carrying out measures directed to the prevention of complications against the background of combined and complex therapy of locally extended cancer of oral cavity mucus allows to decrease the number of hemorrhagic complications to 4,9%, local inflammatory processes — to 2,7% as well as other complications. Conclusion: Planning of accompanying stoma-tologic therapy and organization of adequate curable and rehabilitation measures significantly improves life quality of the patients with locally extended cancer of oral cavity mucus.

AttachmentSize
2013-03_397-399.pdf253.71 KB

Choice justification of a method of immobilization in fractures of lower jaw in patients with chronic generalized periodontal disease of severe degree

Year: 2013, volume 9 Issue: №3 Pages: 387-389
Heading: Stomatology Article type: Original article
Authors: Erokina N.L., Lepilin А.V., Lyapina J.A., Fomin I.V., Rogatina Т.V.
Organization: First Moscow State Medical University n.a. I.M. Sechenov, Saratov State Medical University
Summary:

The purpose of the study: rationalization of selecting of the method of immobilization of the fragments of the mandible in patients with fractures, combined with chronic generalized periodontitis. Material and Methods. There were 70 patients with mandibular fractures in combination with chronic generalized periodontitis who underwent immobilization of the mandible in various ways. Clinical examination of common cytokines and Cross laps of the contents of periodontal pockets have been carried out. The results revealed that patients in the orthopedic treatment of the dynamics observed progression of inflammatory-destructive processes. When immobilization of the mandible with intermaxillary fixation on the titanium screws and the surgical method of treating inflammation at periodontal pockets cropped. Conclusion. Considering inflammatory complications of mandibular fractures in patients who have used the intermaxillary fixation screws in titanium, it has been found out that this method is more optimal.

AttachmentSize
2013-03_387-389.pdf257.21 KB

Structural features of facial skull and maxillary sinuses as predictors of complications in endodontic treatment of teeth of upper jaw

Year: 2012, volume 8 Issue: №3 Pages: 813-816
Heading: Stomatology Article type: Short message
Authors: Lepilin A.M., Mareev O.V., Kovalenko I.P., Mareev G.O.
Organization: Saratov State Medical University
Summary:

Endodontic treatment is considered to be one of the most common procedures in modern dentistry, which also leads to increase of the complications. Objective: to establish the anthropometric characteristics of the structure of the facial skull and maxillary sinus, determining the development of complications of the endodontic treatment of upper jaw. Materials and methods. Measurements have been performed on 105 three-dimensional CT scan of the head, 75 have been in the control group, 30 cases have got foreign bodies of the maxillary sinuses on the CT. Results. We have established the correlation between obtained anthropometrical parameters such as height and width of the face with the type of maxillary sinus pneumatization, also we have studied the critical thickness of the bone plate over the tooth root, which is the main predisposing factor in the development of complications. Conclusion. It is possible to form risk groups according to the type of the structure of the front-skeleton, for additional studies of further endodontic interventions that may reduce their frequency.

AttachmentSize
201203-813-816.pdf253.89 KB

Changes in the trigeminal nerve under the infuence of cortexin in patients with chronic generalized periodontitis

Year: 2012, volume 8 Issue: №2 Pages: 481-484
Heading: Neurology Article type: Original article
Authors: Lepilin A.V., Sholomov I.I., Erokina N.L., Soyher M.G., Nozdrina V.D., Bisultanov H.W.
Organization: Saratov State Medical University, Center for Interdisciplinary Dentistry and Neurology, Moscow
Summary:

Purpose: correction of violations in the trigeminal nerve in patients with chronic generalized periodontitis. Material and methods. A clinical examination and study of the functional activity of the trigeminal nerve in 160 patients with chronic generalized periodontitis. Results. Revealed the presence of various degrees of violations of the functional activity of the trigeminal nerve depending on the severity of the pathological process in periodontal tissues. Conclusion.Neuroprotective therapy in the treatment of patients with periodontal disease leads to normalization of the neurophysi-ology of the trigeminal nerve and promotes more rapid relief of the infammatory process in periodontal tissues.

AttachmentSize
201202_481-484.pdf298.48 KB