Saratov JOURNAL of Medical and Scientific Research

Perinatal Centre, Saratov

A rare medical case in neonatal practice: congenital malformation and spontaneous rupture of the stomach wall

Year: 2015, volume 11 Issue: №2 Pages: 164-167
Heading: Pediatrics Article type: Case report
Authors: Chernenkov Yu.V., Lavrova D.B., Panina O.S., Prokopenko L.E., Larshina E.P., Shikhanova S.V., Belyaeva N.A.
Organization: Perinatal Centre, Saratov , Saratov Clinical Hospital № 8, Saratov State Medical University
Summary:

Congenital malformation is one of the most common causes of infant mortality. The Russian Healthcare Ministry has approved a wide range of measures to decrease the number of babies born with malformations. Due to the measures taken, prenatal diagnostics of such malformations as cardiac malformation, nervous system malformation, various space occupying lesions has become more effective. However, there is a number of malformations hardly detected until the birth. This problem also concerns some abnormalities of the gastrointestinal tract. One of such malformations "silent" during prenatal diagnostics is, particularly, focal aplasia of the stomach muscular layer. This work deals with the case of such malformation observed in a newborn baby.

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Experience in application of enriched breast milk in feeding children with very low birth weight

Year: 2014, volume 10 Issue: №4 Pages: 623-626
Heading: Pediatrics Article type: Original article
Authors: Panina O.S., Chernenkov Yu.V., Arkhangelsky S.M., Prokopenko L.E.
Organization: Perinatal Centre, Saratov , Saratov State Medical University
Summary:

Nursing of very low and extremely low birth weight infants is one of the most difficult problems of modern perinatol-ogy. It is impossible to carry out this task without organization of fee-ding of this group of children. The aim of our research was to study clinical efficiency of breast milk fortifiers administration (human milk fortifier) when preterm infants feeding. Materials and methods. In consequence of this clinical research (with included 60 premature infants born at less than 33 weeks of gestational age with less than 1500g birth weight) the following advantages before other types of feeding were revealed. Results. Mother and child solidarity in the course of breast feeding make deep favorable mutual emotional pressure. It was succeeded to keep all breast feeding advantages and to provide preterm infants special needs in feedstuffs. Human milk fortifiers administration provides higher body weight gain intensity; reduces length of stay in a hospital. It should not go unnoticed high tolerability and lack of complications at its medication usability was noted. Human milk fortifier divorce with small quantity of breast milk and that is especially important for very low and extremely low birth weight infants feeding. Conclusion. All above-mentioned allows recommending human milk fortifiers «PRE NAN FM 85» administration for breast milk in neonatal practice

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Molecular and cellular mechanisms of destabilization of membranes and prenatal discharge of amniotic fluid

Year: 2013, volume 9 Issue: №4 Pages: 644-648
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Mikhaylov А.V., Dyatlova L.I., Chesnokova N.P., Ponukalina Е.V., Glukhova T.N.
Organization: Perinatal Centre, Saratov , Saratov State Medical University
Summary:

Purpose: to establish the role of activation of lipid peroxidation and antioxidant deficiency of blood and amniotic fluid in the destabilization of membranes with early prenatal discharge of amniotic fluid. Material and methods. The analysis of lipid peroxidation products content in blood and amniotic fluid — diene conjugates (DC), malondialdehyde (MDA) and the quantitative determination of total peroxides (OxyStat), the estimation of the total antioxidant status (TAS), the activity of SOD and the content of ceruloplasmin in 20 pregnant with premature rupture of membranes in the gestation period of 22-34 weeks, were hospitalized at the Department of Pathology of Pregnancy of Saratov Perinatal Center in 2012. DC and MDA determination was carried out by conventional spectrophotometric methods of research, quantitative determination of peroxides (OxyStat) was carried out by enzyme immunoassay analyzer «Alfa Prime» («Meredith Diagnostics», 2008 using chemicals made by the company «Bender Medsystems»). The study of antioxidant status of serum and amniotic fluid was performed by enzyme immunoassay analyzer «Alfa Prime» («Meredith Diagnostics», England, 2008). Reagents («Bender Medsystems», Austria) were used to determine the total antioxidant status (TAS) and the SOD activity. To assess the content of ceruloplasmin reagent «Sentinel» (Italy) was used. Results. Indicators of lipid peroxidation in blood and amniotic fluid and anti-radical protection of biological membranes of cells and body fluids in the "mother-placenta-fetus" increased. Conclusion. Systemic activation of lipid peroxidation has been proved to be a
pathogenetic factor in the failure of membranes in prenatal discharge of amniotic fluid. The increase in the blood levels of lipid peroxidation products on the background of the activation of antioxidant system is considered as a prognostic sign of abortion.

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Changes in the cytokine profile of patients blood with premature rupture of amniotic membranes and their pathogenic significance

Year: 2013, volume 9 Issue: №2 Pages: 224-229
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Mikhaylov А.V., Dyatlova L.I., Chesnokova N.P., Ponukalina E.V., Glukhova T.N.
Organization: Saratov State Medical University, Perinatal Centre, Saratov
Summary:

Purpose: Pathogenetic study of new diagnostic and prognostic criteria for evaluation of pregnancy in terms of the cytokine profile of blood. Materials and methods: The analysis of anti-inflammatory and pro-inflammatory cytokines in the blood of 50 pregnant women with preterm rupture of membranes in gestation of 22-34 weeks, who were treated at the Department of Pathology in pregnancy of Saratov Perinatal Center in 2012, was performed. The method of enzyme linked immunosorbent assay using test systems «Vector— Best» (Novosibirsk, Russia). Results:.Clinical and laboratory examination revealed an increase levels of IL-1(3, IL-2, IL-6, IL-8, TNF-a, while reducing the content of IL-4, IL-10 in blood. Conclusion: Manifest signs of possibility of prenatal rupture of membranes and premature labour in 22-34 weeks gestation are combined with increasing of IL-1(3, IL-6, IL-8, TNF-a, IL-2 and with decreasing of IL-10, IL-4 level in the blood, which indicates the need for monitoring the content of these cytokines in the blood for the diagnosis and prognosis of pregnancy.

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Alterations in venous blood flow of lower uterus segment and cervix of uterus at physiological course of preliminary period

Year: 2012, volume 8 Issue: №3 Pages: 729-733
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Chekhonatskaya М.L, Yannaeva N.£., Grishaeva L.A., Rogozhina I.£., Prodanova E.V., Bakhmach V.O.
Organization: Perinatal Centre, Saratov , Saratov State Medical University
Summary:

Research objective. The objective of this research is the study of venous blood flow parameters of lower uterus segment and cervix of uterus at the physiological course of preliminary period. Material and methods. The study was based on the investigation of the course of preliminary period of 90 patients with physiological delivery at term. Results. There is a growing rate of venous blood flow of lower uterus segment and cervix of uterus at rest as well as at peak of contractions. Conclusion. Veins are transformed into structures similar to lacunae at the physiological course of preliminary period. There is a growing rate of venous blood flow of lower uterus segment and cervix of uterus which results in blood storage and seems to be one of the mechanisms leading to cervical dilatation.

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