Saratov JOURNAL of Medical and Scientific Research

Case report

Effectiveness of neure-protective therapy in patients with glaucoma

Year: 2018, volume 14 Issue: №4 Pages: 828-831
Heading: Ophtalmology Article type: Case report
Authors: Aprelev А.Е., Barbos Yu.A., Mukhanko I.Zh., Cherednichenko N.L., Abdulgazizova Z.F., Kataganova A.A., Bernovskaya A.A.
Organization: Mineralovodsky district hospital, Orenburg Regional Clinical Hospital, Orenburg State Medical University, Regional Clinical Diagnostic Center in Stavropol City, Stavropol Regional Clinical Hospital, Stavropol State Medical University
Summary:

The results of clinical evaluation of three patients who were included in the multicenter study of the
effectiveness of neuroprotective treatment and its impact on the quality of life of patients with POAG are
presented in the article. Dynamics of visual acuity, intraocular pressure, total visual fields, photostress
test, contrast sensitivity and quality of life (according to the NEIVFQ-25 questionnaire) in patients
treated with neuroprotective study drug with 10 intramuscular injections administered 5mg once a day
are presented. Data on the improvement of visual functions and quality of life in patients with Stage I, II
and III of POAG who had undergone treatment with the study drug are demonstrated.

Keywords: quality of life
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Clinical features of psoriasis in patients with chronic viral hepatitis and HIV infection

Year: 2018, volume 14 Issue: №4 Pages: 765-769
Heading: Dermatovenerology Article type: Case report
Authors: Tlish M.M., Kuznetsova T.G., Naatyzh Zh.Yu.
Organization: Kuban State Medical University
Summary:

Psoriasis is a chronic dermatosis which manifests itself as benign hyperproliferation of epithelial cells with disrupted differentiation and keratinization. In dermatology polymorbidity is quite widespread and relevant, but at the same time it is not sufficiently studied. Psoriasis in patients with HIV infection is often very severe and poorly amenable to standard methods of therapy, which makes study of clinical and immunological specifics of psoriasis natural history in such patients relevant. The disease significantly worsens quality of life, leads to disability and impairs social life of patients. The paper presents a clinical case in which altered clinical presentation and aggressiveness of psoriasis are related to comorbidities, which requires interdisciplinary therapeutic and diagnostic approach.

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Clinical case of a very rare form of keratodermia in a child

Year: 2018, volume 14 Issue: №4 Pages: 763-765
Heading: Dermatovenerology Article type: Case report
Authors: Slesarenko N.A., Morrison A.V., Marchenko V.M., Moiseev A.A., Ulanova A.M., Dobdina A.Yu.
Organization: Saratov State Medical University
Summary:

 Cases of keratoderma are the most common among genodermatoses and take the second place after a group of ichthyosis. The frequency of occurrence of keratodermia in the world, including Russia, is from 1:300 to 1:15000. There is a very rare form of diffuse keratoderma: Olmsted Syndrome, which in 2009 is described in 10 sources of scientific literature. The defeat not only affects the palms and soles, and skin around the orifices, forms a flexion deformity and con-tracture fingers, until spontaneous amputation. Some observations noted the presence of follicular keratosis of the extremities, leukokeratosis on the face and language, pererastayut joints, alopecia, absence of premolars. We present a clinical case of a patient with this pathology.

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Neurofibromatosis in the practice of dermatology

Year: 2018, volume 14 Issue: №4 Pages: 760-763
Heading: Dermatovenerology Article type: Case report
Authors: Slesarenko N.A., Morrison A.V., Marchenko V.M., Moiseev A.A., Sherstobitova K.Yu., Ishmukhametova R.A.
Organization: Saratov State Medical University
Summary:

Neurofibromatosis belongs to the group of systemic hereditary diseases from the group of phakomatosis, characterized by developmental defects of ectodermal and mesodermal structures, mainly of the skin, nervous and bone systems, with an increased risk of developing malignant tumors. There are 7 types of the disease include a wide range of clinical manifestations even within the same family: a progressive course, the involvement of almost all organs and systems in the process, a high risk of complications, including many serious and fatal (cardiovascular) pulmonary insufficiency due to severe skeletal abnormalities, malignant degeneration by neurofibromas, etc.). An analysis of 5 clinical cases with neurofibromatosis is presented.

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Clinical case of the Besnier-Boeck-Shaumann syndrome in dermatology practice

Year: 2018, volume 14 Issue: №4 Pages: 755-757
Heading: Dermatovenerology Article type: Case report
Authors: Slesarenko N.A., Morrison A.V., Marchenkna E.M., Moiseev A.A., Roshchepkin V.V.
Organization: Saratov State Medical University
Summary:

Sarcoidosis (Besnier-Boeck-Schaumann syndrome) is a benign systemic disease, which is based on the defeat of the reticuloendothelial system with the formation of epithelioid cell granulomas without caseosa and perifocal inflammation in the absence of Mycobacterium tuberculosis. It occurs in all countries of the world, but the highest incidence is recorded in Northern Europe and the United States. The incidence ranges from 11 to 35 per 100,000 population. The etiology of the disease is unknown. The pathogenesis is based on delayed hyperergic immune reactions, which lead to the formation of granulomas involving T cells, as well as the release of various chemokines and cytokines, including tumor necrosis factor (TNF-alpha). The aim of the work is to present a clinical case, due to the rarity of dermatosis, as well as the complexity of diagnosis.

Keywords: rare dermatoses
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Professor N. E. Kushev as a country doctor, a scientist, a teacher and a public figure (to the 160-th anniversary)

Year: 2018, volume 14 Issue: №4 Pages: 699-703
Heading: Scientific schools and memorable dates Article type: Case report
Authors: Zavyalov A.l., Petrov V.V., Kustodov S.V., Kravtsov O.A.
Organization: Saratov State Medical University
Summary:

The article presents biographical information about Professor N. E. Kushev. It describes his scientific and practical contribution to the development of native medicine at the turn of the XIX-XX centuries including the organization of malaria control, training of scientific and pedagogical staff at the medical faculty of the Saratov University and public activities.

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Circular anchorage of the spine in the correction of scoliotic deformity.

Year: 2018, volume 14 Issue: №3 Pages: 586-591
Heading: Traumatology and Orthopedics Article type: Case report
Authors: Stepukhovich S.V., Zaretskov V.V., Arsenievich V.B., Likhachev S.V., Shul'ga A.E., Zaretskov V.V.
Organization:
Summary:

Aim: to demonstrate clinical case of surgical treatment of scoliotic deformity of the spine in a 17-year-old child. It is shown that the correction of sagittal profile achieved by 2-stage intervention and normalized global balance parameters in combination with circular spine anchorage allows providing earliest and fullest rehabilitation of a child.

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The peculiarities of morphological differential diagnostics of intradural tumor localized at the level of medullary cone and cauda equina roots

Year: 2018, volume 14 Issue: №3 Pages: 567-570
Heading: Traumatology and Orthopedics Article type: Case report
Authors: Matveeva O.V., Bazhanov S.P., Ponomareva Е.Е., Tolkachev V.S.
Organization: Penza Regional Oncology Centre
Summary:

Aim: to demonstrate the necessity of modern methods of morphological verification in the differential diagnostics of primary and secondary neoplastic lesion of spinal cord. It is shown that histogenesis of tumor cells should be regarded from the viewpoint of comparative assessment of traditional and complementary methods of morphological verification that outlines the necessity of complex differential morphological diagnostics with apparent priority of immunohisto-chemical methods for the verification of final diagnosis of metastatic lesion in a rarely seen localization.

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The tactics of surgical treatment in metastatic lesions of upper cervical spine.

Year: 2018, volume 14 Issue: №3 Pages: 498-501
Heading: Traumatology and Orthopedics Article type: Case report
Authors: Bazhanov S.P., Gulyaev D.A., Ulyanov V.Yu., Ostrovskiy V.V., Tolkachev V.S.
Organization: The Almazov National Medical Research Centre, Head of Second Cerebral and Spinal Cord Tumors Department, Doctor of Medical Sciences
Summary:

We demonstrated a successful case of surgical treatment of the patient with metastatic lesion of upper cervical spine with respect to multidisciplinary approach. We performed simultaneous two-stage surgical intervention, the first stage being occipitospondylodesis by multi-segment construction; and second —tumor resection from expanded combined access. It has been stated that the proposed surgical tactics allows performing curative resection in one surgical session without neurological deficit buildup in the postoperative period.

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Rituximab treatment efficacy in a patient with systemic lupus erythematosus with severe thrombocytopenia

Year: 2018, volume 14 Issue: №3 Pages: 417-419
Heading: rheumatology Article type: Case report
Authors: Alexandrova O.L., Nikitina N.M., Magdeeva N.A., Shmelkova M.Yu., Grigoryeva S.N.
Organization: Saratov Regional Clinical Hospital, Saratov State Medical University
Summary:

The article presents a clinical case of systemic lupus erythematosus with severe thrombocytopenia in a 55 year old patient. The standard therapy of usage of high doses of glucocorticoids, cyclophosphamide and intravenous im-munoglobulin was not effective. Application of Rituximab improved the course of disease, decreased the severity of thrombocytopenia, led to disappearance of leucopenia and anemia.

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