Saratov JOURNAL of Medical and Scientific Research

vegetative regulation

Comparative evaluation of autonomic regulation of circulation in patients undergone coronary artery bypass grafting or correction of acquired valvular heart disease

Year: 2018, volume 14 Issue: №1 Pages: 45-49
Heading: Internal Diseases Article type: Short message
Authors: Kiselev A.R., Vulf K.A., Shvartz V.A., Karavaev A.S., Borovkova E.l., Bockeria O.L.
Organization: Bakulev Center of Cardiovascular Surgery, Saratov State Medical University n.a. V.I. Razumovsky Research Institute of Cardiology, Saratov state university
Summary:

The aim of the research was to study the peculiarities of vegetative regulation of blood circulation in cardiac surgery patients who underwent coronary artery bypass grafting (CABG) or correction of acquired valvular heart disease (CAVHD). Material and Methods. In this study we included 42 patients (12 women; 63 (57; 67) years), who underwent CABG, and 36 patients (16 women; 58 (47; 65) years) who underwent CAVHD. The synchronous 15 minutes records of electrocardiogram and photoplethysmogram (PPG) were performed in all patients before and after surgery. Time domain and frequency domain measures of heart rate variability (HRV) and index of synchronization between low-frequency (LF) oscillations in HRV and PPG (index S) were analyzed. Results. Most studied autonomic indices did not have statistically significant differences between patients with CABG and CAVHD in the study stages, except for heart rate, which was higher in patients before CAVHD (p=0,013). Conclusion. The values of HRV and index S do not depend on the difference in the clinical status and the features of performed cardiac surgical interventions between patients with CABG and CAVHD.

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Synchronization of low-frequency rhythms in electroencephalogram by respiration with linear dependent time frequency.

Year: 2016, volume 12 Issue: №4 Pages: 541-548
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Karavaev A.S., Runnova A.E., Borovkova E.l., Ishbulatov Y.M., Khorev V.S., Kiselev A.R., Zhuravlev M.O., Ponomarenko V.I., Prokhorov M.D., Bezruchko B.P., Koronovsky A.A..
Organization: Saratov Branch of Institute of Radio Engineering and Electronics n.a. V.A. Kotelnikov, Saratov State Medical University, Saratov state university
Summary:

The aim of the present study was to investigate the features of interaction of low-frequency rhythms in delta band of electroencephalogram (EEG) and processes in vegetative regulation of circulation with respiration. Materials and methods. 19 leads of EEG, photoplethysmogram (PPG) and respiration were simultaneously recorded in four healthy males (19-25 years old) during 30 minutes physiological test with linearly increasing frequency of respiration. Modern methods of nonlinear dynamics were used to diagnose the presence of phase and frequency synchronization between respiration and low-frequency rhythms in delta band of EEG and in PPG. Results. We found significantly long sections of synchronization of delta rhythms in cervical leads of EEG and low-frequency rhythms in PPG by respiration with linearly increasing frequency. Conclusion. Obtained results correlate well with established hypothesis which suggest that low-frequency rhythms in baroreflectory regulation of circulation are in complex dynamic relationships with structures of brain stem. A method was proposed for quantitative evaluation of synchronization strength between respiration and low-frequency rhythms in electrical brain activity in physiological tests with respiration with frequency linearly increasing in time.

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Oscillatory processes in vegetative regulation of cardiovascular system (Review)

Year: 2011, volume 7 Issue: №1 Pages: 034-039
Heading: Physiology and Pathophysiology Article type: Review
Authors: Kiselev A.R., Gridnev V.I.
Organization: Saratov Institute of Cardiology, Russia
Summary:

The research work provides current understanding of the functional organization of vegetative regulation of cardiovascular system. The basic oscillatory processes in vegetative regulation system have been determined, and the information about their functional properties has been generalized. The most significant oscillatory processes are main heart rhythm, respiration and low-frequency oscillations in vegetative regulation of cardiovascular system. The article considers intersystem interactions involving the vegetative regulation of cardiovascular system

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Comparison of dynamic of autonomic control indices in cardiovascular system under the treatment by ACE inhibitor (Enalapril) and beta-blocker (Metoprolol) in patients with hypertension

Year: 2010, volume 6 Issue: №1 Pages: 061-072
Heading: Internal Diseases Article type: Original article
Authors: A.R. Kiselev, A.S. Karavaev, V.I. Gridnev, O.M. Posnenkova, V.A. Shvartz, V.I. Ponomarenko, M.D. Prokhorov, B.P. Bezruchko
Organization: Saratov National Research University n.a. N. G. Chernyshevsky, Saratov Institute of Cardiology, Russia, Saratov Branch of Institute of Radio Engineering and Electronics n.a. V.A. Kotelnikov
Summary:

The objective of the present research was to compare the influence of Enalapril and Metoprolol on synchronization of 0.1 Hz-regulation of heart and blood microcirculation. 42 patients aged 49±9 years old with hypertension I, II were included in the study. 0.1 Hz-oscillations in heart rate variability (HRV) and blood microcirculation were registered during the passive orthostatic sign while breathing spontaneously. The duration of each test was 10 minutes. Synchronization was estimated as a phase difference between 0.1 Hz-rhythms in heart rate and in filling of blood microcirculation. Quantitative measures of synchronization were also estimated. In addition frequency values of HRV spectrum in LF- and HF-ranges were assessed. Enalapril and Metoprolol had comparable effect on blood pressure reduction. Treatment with both Enalapril and Metoprolol in patients with significant vegetative dysfunction resulted in repair of functional interaction between 0.1 Hz-regulation of heart and blood microcirculation. Enalapril was preferred in hypertensive patients
with prevalence of disorders of vegetative regulation of blood microcirculation. Metoprolol influenced positively on 0,1 Hz-rhythm synchronization in patients with predominance of heart vegetative regulation dysfunction and in patients with sympathicotonia. In patients with hypertension and initially normal level of synchronization of 0.1 Hz-mechanisms treatment with Enalapril or Metoprolol caused functional dissociation. Differentiated approach to the choice of hypertensive therapy should consider individual peculiarities of system vegetative dysfunction. The level of synchronization of 0.1 Hz-rhythms in cardiovascular system should especially be evaluated initially and during the treatment

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Variability Of Heart Rate In Patients With Chronic Brucellosis: Peculiarities Of Vegetative Regulation

Year: 2009, volume 5 Issue: №4 Pages: 578-580
Heading: Infectious Diseases Article type: Short message
Authors: А.А. Reshetnikov, A.A. Shuldyakov, M.V. Safonova
Organization: Saratov State Medical University, Saratov City Clinical Hospital № 2
Summary:

The research goal is to study vegetative regulation of heart rate in patients with chronic brucellosis of various clinical forms and activity degrees. 80 patients with chronic brucellosis have been examined. Predominant influence of sympathetic part of vegetative nervous system on regulation of heart rate in active form of chronic brucellosis and influence of parasympathetic part in inactive form have been revealed. Character of vegetative dysfunction depends on clinical form of the disease only in the case of active chronic brucellosis

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THE DYNAMICS OF 0,1 HZ-COMPONENT OF HEART RATE VARIABILITY AT PATIENTS WITH ARTERIAL HYPERTENSION AT TREATMENT BY FOSINOPRIL AND ATENOLOL

Year: 2008, volume 4 Issue: №1 Pages: 84-87
Heading: Internal Diseases Article type: Original article
Authors: O.V. Shevchenko, A.R. Kiselev, V.I. Gridnev, O.M. Posnenkova, A.N. Strunina, A.A. Svistunov
Organization: Saratov Institute of Cardiology, Russia, Saratov State Medical University
Summary:

Aim: to study dynamics of the 0,1Hz-componentofthe heart rate variability(HRV) spectrum in patients with arterial hypertension taking fosinopril and atenolol. 49 patients with hypertension were enrolled (age - 46+/-7 years). Fosinopril and atenolol were administered consequently. The power of 0,1 Hz-component of the HRV spectrum was assessed during a passive orthostatic test. Results: In patients taking fosinopril and atenolol comparable decrease of blood pressure was observed. Atenolol caused reliable decrease of a heart rate during orthostatic test. The power dynamics of 0,1Hz-componentwas comparable in patients taking fosinopril and atenolol. Conclusion: fosinopril and atenolol influenced similar on 0,1-Hz mechanisms of vegetative heart control system.

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