Saratov JOURNAL of Medical and Scientific Research

Perm State University of Medicine n.a. academician E.A. Vagner

Immuno-morphological features of the rat's thymus at the experimental administration of cytostatics

Year: 2016, volume 12 Issue: №1 Pages: 12-14
Heading: Macro- and Micromorphology Article type: Original article
Authors: Lebedinskaya Е.А., Lebedinskaya O.V., Godovalov А.Р., Prokudin V.S.
Organization: Perm State University of Medicine n.a. academician E.A. Vagner
Summary:

The aim is to identify the changes in the rat's thymus structure under immunosuppression induced injection of cyclophosphamide with the use of morpho-histochemical and morphometric methods. Material and methods. For immunosuppression of animals cyclophosphamide at 100mg/kg body weight 4-fold with a 24-hour interval was injected intraperitoneally. Thymus serial paraffin sections were stained with hematoxylin and eosin, azure ll-eosin, methyl green pyronin according to Brachet, and periodic acid-Schiff before and after treatment with amylase. Results. Significant morphological changes in the thymus at rats with injection of cyclophosphamide were established. Morpho-histochemical changes in the rat's thymus characterize the immunosuppressive state of the experimental animals' organisms. Conclusion. It was shown the necessity of complex morphological studies including macrophage activity and characteristics of the subpopulation of mononuclear leukocytes spleen, changes in the structure of hematopoietic and lymphoid organs under immunosuppression induced by cyclophosphamide.

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Microflora of root canals during the treatment of chronic forms of apical periodontitis

Year: 2013, volume 9 Issue: №3 Pages: 447-449
Heading: Stomatology Article type: Short message
Authors: Mozgovaya L.A., Zadorina I.I., Bykova L.P., Godovalov A.P.
Organization: Perm State University of Medicine n.a. academician E.A. Vagner
Summary:

Objective: to study the qualitative and quantitative composition of microflora in the root canals of teeth in the treatment of patients with chronic apical periodontitis. Material and methods. The efficiency of the treatment of chronic apical periodontitis was determined in two groups of patients: the main group 1 (18 persons) and comparison group 2 (11 persons), by examining culture-biochemical properties of the contents of the teeth root canal (RC), the concentration of total protein and leukocyte. For endodontic treatment in group 1 the «Radent» was used and in group 2 was used «Krezodent.» Results. In group 1 suppression of anaerobic microorganisms was found and the reduce of occurrence of streptococci, the growth of Candida, Enterobacterium and Corynebacterium did not detected. In group 2, rising Candida, pyogenic streptococci, staphylococci and anaerobic microorganisms was found. The concentration of total protein and white blood cells in teeth RC contents in groupl decreased significantly and in group 2 contents did not change. Conclusion. The pathological process in the periodontium under chronic apical periodontitis supported predominantly coccal and anaerobic microflora, with exacerbation prevail streptococci, Neisseria and enterobacteria. Inflammation of the periodont supports leukocyte cells that synthesize the protein molecules. «Radent» has a strong antibacterial and anti-inflammatory effect.

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Non-motor symptoms in parkinson’s disease

Year: 2012, volume 8 Issue: №2 Pages: 535-538
Heading: Neurology Article type: Original article
Authors: Torgan T.I., Baidina T.V.
Organization: Perm State University of Medicine n.a. academician E.A. Vagner
Summary:

The goal of the research was to investigate some non-motor disorders at patients with Parkinson disease (PD) and to determine their relations to the main manifestations of the disease. 68 patients with PD without dementia were studied. Duration of disease was 4 (2-6) years. The following scales were used: Modifed Fatigue Impact Scale (MFIS), Unifed Parkinson Disease Rating Scale (UPDRS, part 3), Hospital Anxiety and Depression Scale (HADS), A. M. Veyn Questionnaire for autonomic disturbances and the Epworth Sleepiness Scale (ESS). The results of this study have revealed the presence of emotional disorders, fatigue, autonomic dysfunction and dyssomnia at patients with PD. Non-motor symptom severity does not depend on age and sex of the patients, as well as the main motor symptoms of the disease. The relationships of the examined non-motor symptoms were revealed.

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Infuence of depression on stability in elderly patients with discirculatory encephalopa-thy

Year: 2012, volume 8 Issue: №2 Pages: 383-388
Heading: Neurology Article type: Original article
Authors: Baidina T.V., Sosnitskaya D.M.
Organization: Perm State University of Medicine n.a. academician E.A. Vagner
Summary:

The goal of the research is studying of patients who suffer from disequilibrium because of the gerontal dyscir-culatory encephalopathy (DE) with borderline disorders. The research also highlights possible relationship between depression and postural abnormalities using stabilometrics. 72 patients of 75 – 90 years old with dyscirculatory en-cephalopathy were examined. There were clinical and psychometric trials. Mental depression was detected according to depressive disorder criteria of ICD-10 (International Classifcation of Deseases-10th revision). Clinical assessment of static sense according to R. Bohannon scale (1989). Stabilometrics was carried out in compliance with European open eyes — methodology using “MBN — Biomechanics” complex (Moscow).During the tests two groups of patients were sorted out. They are the main group consisted of 56 patients with depressive symptom and a group for comparison consisted of 16 patients without anxiety or depression. The groups are comparable to age and cognitive defect rate. There was no difference according to clinical assessment of static sense according to R. Bohannon scale. The length and the area of a stabilogram, the centre of pressure movement speed in the main group is higher because the oscillation amplitude in the medium frequency area in frontal plane.The research concluded that depression intensifes balance disorder at patients with gerontal dyscirculatory en-cephalopathy. This disorder can be revealed by computer stabilometrics method. These disorders are the consequences of the infuence of phrenopathy on muscle tone.

Keywords: stabilometrics
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