Saratov JOURNAL of Medical and Scientific Research

Svistunov A.A.

Pro-rector on Common Matters of Moscow Medical Univesity n.a. I.M. Sechenov, Professor, Doctor of Medical Science

Effects of intranasal medicines on microcirculatory blood flow of nasal cavity

Year: 2012, volume 8 Issue: №3 Pages: 791-794
Heading: Otolaryngology Article type: Short message
Authors: Svistunov A.A., Mareev О.V., Mareev G.О., Bukreev I.S.
Organization: Saratov State Medical University
Summary:

The article describes the new method of assessment of microcirculatory blood perfusion and introduction of this method into the study of intranasal drugs effects on mucosal blood flow in the nasal cavity. The research work presents some different groups of drugs — decongestants, physical solutions for irrigation therapy and local corticosteroids. It has been revealed that intranasal decongestants have a significant effect on the intranasal blood flow, but their intake affects the mucosal membrane of the nasal cavity. Other drugs have not shown such negative effects and have not caused tachyphylaxis. Therefore these medicines may be recommended for more common use in ENT-practice.

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Renal dysfunction and state of metabolic and hemodynamic factors in patients with arterial hypertension

Year: 2011, volume 7 Issue: №4 Pages: 837-842
Heading: Internal Diseases Article type: Original article
Authors: Kurkina T.V., Bogoslovskaya S.I., Svistunov А.А., Kodochigova A.L, Glybochko G.Kh., Klochkov V.A.
Organization: Saratov State Medical University, Saratov Regional Hospital for Veterans of Wars, Saratov Institute of Cardiology, Russia, First Moscow State Medical University n.a. I.M. Sechenov
Summary:

The aim of the investigation is to carry out comparative evaluation of metabolic and hemodynamic indices in patients with arterial hypertension (AH) and renal dysfunction; to study the interrelation between arterial blood pressure level normalization and the presence or lack of microalbuminuria (MAU) in the morning urine portion of patients with AH after therapy with antihypertensive preparations (APs) of various groups. Methods. 121 persons have been investigated, 91 out — patients of both sexes, aged 33-55, with the diagnosis of arterial hypertension of stage II risk III, who have been taking Perindopril, Telmisartan and Bisoprolol for3 months. The control of arterial pressure level, biochemical analysis of metabolic indices and morning urine portion test for microalbuminuria has been carried out. Results. MAU has been revealed in 17,6% patients, occurring more frequently in men than in women. Microalbuminuria is accompanied by reliable decrease of total and ionized calcium and magnesium concentrations, an increase of potassium level in blood plasma, increase of cholesterol, triglycerides, glucose and levels. Patients with AH and renal dysfunction reliably demonstrate higher levels of systolic and diastolic arterial pressure in the morning and evening hours, their normalization effect after APs intake is significantly interconnected with MAU presence. Conclusion. In patients with AH and MAU the main risk factors of cardio-vascular diseases development are more expressed. Microalbuminuria is a risk factor in patients with arterial hypertension and may influence on the basic blood electrolyte balance. While carrying out antihypertensive therapy the presence of MAU should be taken into consideration

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Disturbances in system of cytokines and lipid exchange in patients with psoriasis

Year: 2011, volume 7 Issue: №2 Pages: 434-437
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Akhlupkina M.V., Svistunov A.A., Bakulev A.L, Zakharova N.B., Nikitina V.V.
Organization: Saratov State Medical University, First Moscow State Medical University n.a. I.M. Sechenov
Summary:

Investigation of proinflammatory and antiinflammatory cytokines content in blood serum (IL-1 (3, IL-4, IL-6, IL-8, IL-10, INF-y, IL-17) was carried out for establishment of clinical and diagnostic value of disturbances of immunoregulatory processes and lipid spectrum in patients with psoriasis. Method of solid phase immune-enzyme analysis and indicators of lipid profile on biochemical analyzer Stat Fax were used in the study. It was found out that psoriasis exacerbation was accompanied by change of proinflammatory and antiinflammatory cytokines in blood serum and increase of lipid profile level. The hyperproliferation and inflammatory skin changes in case of psoriasis exacerbation were accompanied by hyperproduction of cytokines and disturbance of immunoregulatory processes to Th-2 cellular answer including autoimmune processes. The described changes led to raised synthesis of lipids and to their entry into peripheral blood flow. Determination of proinflammatory cytokines and lipids level in blood serum in patients with psoriasis can be used for an estimation of severity of disease, its development prognosis and administered therapy

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Genetic pathogenesis of essential arterial hypertension (the review)

Year: 2011, volume 7 Issue: №1 Pages: 083-087
Heading: Internal Diseases Article type: Review
Authors: Shevchenko O.V., Svistunov А.А., Borodulin V.B., Ruta A.V., Bychkov E.N.
Organization: Saratov State Medical University, First Moscow State Medical University n.a. I.M. Sechenov
Summary:

It is proved that genetic factors may be considered as fundamental in the development of essential arterial hypertension (AH). Important role in this process belongs to the genes whose products are involved in regulating blood pressure - adrenergic, renin-angiotensin-aldosterone, and homocyclic bradykinin systems. These systems are closely connected by serial and parallel chemical reactions that enable to use genetic testing to determine the state of the whole system. Analysis of polymorphic markers of different groups of genes encoding components of the renin-angiotensin-aldosterone system allows to define the role of each of the pathogenic factor of hypertension in the development of the disease

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Pharmacodynamic and pharmacoeconomic aspects of application of antihypertensive preparations of various groups in patients with arterial hypertension

Year: 2010, volume 6 Issue: №3 Pages: 504-510
Heading: Clinical Pharmacology Article type: Original article
Authors: Kurkina T.V., Svistunov А.А., Bogoslovskaya S.I., Klochkov V.A., Glybochko G.H., Shuldyakov V.A., Luchinina EM., Levanov A.N.
Organization: Saratov State Medical University, Saratov Regional Hospital for Veterans of Wars, Saratov Institute of Cardiology, Russia
Summary:

At the background of the therapy for 3 months with Perindopril, Telmisartan and Bisoprolol, the patients with arterial hypertension were noted to decrease systolic and diastolic arterial pressure. The preparations under investigation had different effects on electrolyte metabolism. Therapy with Telmisartan turned out to have the least effect on electrolyte metabolism. Microalbuminuria is a risk factor in patients with arterial hypertension and may influence on the basic blood electrolyte balance. Bisoprolol should be recommended as the most preferable therapy for arterial hypertension from the pharmacoeconomic point of view. In order to control morning systolic arterial pressure the preference should be given to Perindopril, while for controlling evening systolic arterial pressure the preference should be given to Telmisartan

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Practical classes for graduates on orthopedic stomatology as logical continuation of lecture course on orthodontia and complex maxillary prosthesis

Year: 2010, volume 6 Issue: №2 Pages: 474-476
Heading: Pedagogics and Education Article type: Short message
Authors: A.A. Svistunov, L.A. Googe, Yu.Yu. Rosalieva
Organization: Saratov State Medical University, First Moscow State Medical University n.a. I.M. Sechenov
Summary:

In this article the generalized long-term experience of active forms of students independent work organization is considered

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Using of computer simulation in surgical treatment of patients with fractures of proximal femur

Year: 2010, volume 6 Issue: №2 Pages: 419-421
Heading: Traumatology and Orthopedics Article type: Original article
Authors: I.A. Norkin, A.A. Svistunov, D.A. Markov, O.A. Kautz, S.P. Shpinyak A.G. Khachatryan, V.N. Belonogov
Organization: Saratov State Medical University, Saratov Scientific Research Institute of Traumatology and Orthopedics, First Moscow State Medical University n.a. I.M. Sechenov
Summary:

In this article questions of femur computer models base making for future it using in free patients medicine are discussed. Last allows possibility for educate doctors using computer models, increase their professional level and makes complications decrease. Comparing of fixation properties of DHS and PFN-A was performed

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Change in function of thl - and th2-lymphocytes and cytokine profile at chronic intoxication of ethanol

Year: 2010, volume 6 Issue: №2 Pages: 307-309
Heading: Anaesthesiology and Reanimatology Article type: Original article
Authors: A.A. Svistunov, P.F. Zabrodsky V.G. Lim, V.A. Grishin
Organization: Saratov State Medical University
Summary:

It has been established during the experiments carried on noninbred rats that chronic intoxication of ethanol (30 days, total dose - 6,0 LD50) essentially reduces concentration of cytokines (IFNy, IL-2, IL-4, IL-6,IL-10) in blood, reduces interrelation of IFNy/IL-4 in comparison with the control, suppresses immune reactions, indicating the greater lesion of Th1-cells in comparison with Th2-lymphocytes

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Activation of Lipoperoxidation Pro¬cesses as a Typical Process of Cell Biomembrane Destabilization at Neoplasias of Different Localization

Year: 2010, volume 6 Issue: №2 Pages: 267-270
Heading: Physiology and Pathophysiology Article type: Review
Authors: A.A. Svistunov, N.P. Chesnokova, V.Yu. Barsukov, T.D. Selezneva, E.V. Zyablov
Organization: Saratov State Medical University, First Moscow State Medical University n.a. I.M. Sechenov
Summary:

The research was aimed to generalize the results of own investigations pertaining to activation of lipid peroxidation in pathogenesis of rectal cancer, endometrial cancer, thyroid cancer and breast cancer. the research shows that extreme intensification of lipoperoxidation processes being a regular manifestation of paraneoplastic disorder and correlating to the degree of spread of neoplasias with different localization needs appropriate medical treatment

Keywords: -
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Educational process organisation in internship of internal diseases

Year: 2010, volume 6 Issue: №1 Pages: 206-208
Heading: Pedagogics and Education Article type: Short message
Authors: A.A. Svistunov, A.A. Protopopov, A.P. Rebrov, E.Yu. Ponomareva, E.V. Voloshinova
Organization: Saratov State Medical University
Summary:

The article gives close attention to the experience of Department of Hospital Therapy concerned with the organisation of the first step post-diploma education of interns who are trained at the Clinical Department of Internal Diseases

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