Saratov JOURNAL of Medical and Scientific Research

Irkutsk State Medical University

Lipid peroxidation and glutathione antiox-idant protection in patients with an exacerbation of chronic pancreatitis

Year: 2013, volume 9 Issue: №2 Pages: 259-262
Heading: Internal Diseases Article type: Original article
Authors: Merinova N.I., Kozlova N.М., Kolesnichenko L.S., Suslova A.I., Leonova Z.A.
Organization: Irkutsk State Medical University

Aim: to assess the levels of lipid peroxidation (LPO) products of malondialdehyde (MDA) and glutathione system in patients with the exacerbation of chronic pancreatitis (CP). Material and Methods: 80 patients with exacerbation of CP and 23 controls have been investigated. The level of reduced glutathione (GSH) and activity of enzymes of glutathione reductase (GR), glutathione transferase (GT), glutathione peroxidase (GP) have been determined in plasma and erythrocytes, while the MDA has been studied in plasma. Results: The MDA levels in plasma were higher in CP patients as against the values of the controls. The MDA level correlated positively with intensity of pain. Increased GSH concentration and activity of GT were revealed in plasma. In the erythrocytes reduction in GP activity and GSH concentration were determined. Conclusion: In the exacerbation of chronic pancreatitis lipid peroxidation and reduced antioxidant protection have been activated.

2013-02_259-262.pdf263.69 KB

Erythropoietin in patients with type 1 diabetes (review)

Year: 2012, volume 8 Issue: №1 Pages: 159-163
Heading: Endocrinology Article type: Review
Authors: Khantakova Е.А., Khamnueva L.Yu.
Organization: Irkutsk State Medical University

The article analyzes the literature on the issue of regulation of erythropoietin in patients with type 1 diabetes. The connection between the secretion of erythropoietin disturbance with the development and progression of diabetes complications has been observed. Various pleiotropic effects of erythropoietin have been considered

201201_159-163.pdf284.79 KB