Saratov JOURNAL of Medical and Scientific Research

Denisova T.P.

Saratov State Medical University, Department of Therapy and Gerontology, Professor, Doctor of Medical Science

Erythrocyte system in elderly: ageing aspects

Year: 2018, volume 14 Issue: №2 Pages: 341-345
Heading: Gerontology and geriatrics Article type: Original article
Authors: Malinova L.I., Denisova Т.Р., Lipatova Т.Е., Khvostikova D.E., Yegorova A.V.
Organization: Saratov State Medical University
Summary:

The purpose of the study was an assessment of erythrocyte system age-dependent characteristics in elderly population dwelling in the same territory during the time period equal to the average life span in the region. Material and Methods. We perform the compare of hematological parameters of 800 patients with hypertension and coronary heart disease hospitalized during 25-years period. Results. In senile patients, red blood cells and hemoglobin levels signifi- cantly decrease, but platelet characteristics remain intact. Revealed differenced are similar during all 25-year period of observation. Conclusion. Over the past 25 years, the trend of age-related decline in the number of red blood cells and hemoglobin has been preserved. The average hemoglobin content in erythrocyte (MCH) during the aging process tends to decrease, which has become statistically significant in recent years. The principal difference of the obtained data from the results of obtained 25 years ago is the absence of an age-related increase in the volume of erythrocytes and a higher level of the average concentration of hemoglobin in the erythrocyte.

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Healthy ageing and regional health care system of the Great Patriotic War veterans

Year: 2018, volume 14 Issue: №2 Pages: 330-334
Heading: Gerontology and geriatrics Article type: Author's opinion
Authors: Denisova Т.P.,Lipatova Т.Е., Shuldyakov V.A., Kovalev E.P., Alipova L.N.
Organization: Saratov Regional Hospital for Veterans of Wars, Saratov Ministry for Public Health
Summary:

The term of "Healthy Ageing" is about creating the environments and opportunities that enable people to be and to do what they value throughout their lives. Healthy ageing require multipurpose policy framework with biological, social, economic, cultural and ecological aspects. The long-term experience of Saratov Regional Hospital for War Veterans in development and management of competencies required for healthy ageing programs is generalized in the article. Science evidence base of healthy ageing was formulated including results of the original studies with veterans of Great Patriotic War involved.

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Clinical diagnosis in terms of insurance medicine

Year: 2018, volume 14 Issue: №2 Pages: 327-330
Heading: Gerontology and geriatrics Article type: Author's opinion
Authors: Denisova Т.Р., Lipatova Т.Е., Malinova L.I., Tyultyaeva L.A., Kovalev Е.Р., Alipova L.N., Vakhlyueva O.G.
Organization: Saratov Regional Hospital for Veterans of Wars, Saratov State Medical University
Summary:

Medical institutions in the conditions of insurance medicine are faced with not always justified interference of insurance companies in the structure of diagnosis and diagnostic process, whose violate the essence of the concepts of clinical classifications and statistical coding of diagnoses provided by ICD-10. Such a situation ultimately harms the patient and society, makes it difficult both to monitorthe adequacy of the ongoing treatment activities, and to protect the patient's rights to receive qualified medical care and doctor's rights.

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Interaction of atherosclerosis and ageing: is there any discussion questionable?

Year: 2018, volume 14 Issue: №2 Pages: 322-327
Heading: Gerontology and geriatrics Article type: Author's opinion
Authors: Denisova Т.Р., Lipatova Т.Е., Alipova L.N., Yegorova A.V.
Organization: Saratov Regional Hospital for Veterans of Wars, Saratov State Medical University
Summary:

Age-related diseases and their link to involutionary processes in human organism remain as one of the burning problems in internal medicine. The article focuses on the discussable questions of the most common mechanisms of atherogenesis and ageing, their similarity and difference. Both processes mutually burdens each other, bringing the "fading" of the organism closer.

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Theoretical background of healthcare management in the conditions of social and economic instability

Year: 2015, volume 11 Issue: №1 Pages: 065-068
Heading: Health Service Organization Article type: Author's opinion
Authors: Shuldyakov V.A., Chernenkov Yu.V., Denisova Т.Р.
Organization: Children's Hospital of the Saratovsk Region, Saratov, Saratov State Medical University
Summary:

Purpose: to develop fundamental basis of science based healthcare management in social and economic instability. Public health state (1998-2008, selected region) was characterized by cardiovascular health parameters (Code IX, ICD-10). Systematic review was performed according to PRISMA guidelines. Dynamic characteristics of major cardiovascular diseases in social and economic instability considered as a cause of a population system destabilization were reconstructed. Conclusion. Fundamentals of science based healthcare management in social and economic instability include long- and short-term prognosis of public health characteristics as the result of multifactor external influences on cardiovascular diseases prevalence.

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The senile kidney

Year: 2015, volume 11 Issue: №1 Pages: 046-049
Heading: Gerontology and geriatrics Article type: Lecture
Authors: Denisova Т.Р., Lipatova Т.Е., Chernenkov Yu.V., Nazarov M.l.
Organization: Regional Hospital for War Veterans, Saratov, Saratov State Medical University
Summary:

The given work summarizes external data and self-obtained results on development and diagnostic of kidney involution modifications. Article discusses definition of "senile kidney" as a clinical and pathomorphological term. Major statements on pathophysiological causes of age-associated renal disorders and their prognosis, specifics of chronic kidney disease in elderly and senile patients have been reviewed. Phenomenon of renal "multimorbidity" in eldely maximizes worsening risk of unmodifiable kidney function.

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Heart ischemic disease and longevity: unsolved problems

Year: 2015, volume 11 Issue: №1 Pages: 037-041
Heading: Gerontology and geriatrics Article type: Original article
Authors: Markova T.Yu., Malinova L.I., Denisova Т.Р.
Organization: Regional Hospital for War Veterans, Saratov, Saratov State Medical University
Summary:

The purpose of the study was to estimate clinical signs and course of coronary heart disease in long-livers and centenarians. Material and Methods. The study included overall population of Saratov — Engels agglomeration's long-livers (>=90 years old, n=198). Results. The rates of major clinical forms of coronary heart disease were detected: atrial fibrillation — 10.6%, chronic heart failure (with preserved ejection fraction) — 10.1 % and angina — 5.1 %. Myocardial infarction was verified in 9.6% of long-livers. Myocardial scar criteria prevailed over myocardial infarction history. Received data corroborated dissolving phenomena of coronary heart disease and noninsulin dependent diabetes mellitus in long-livers. Gender differences in electrophysiological parameters were detected in long-livers. Centenarians with the history of myocardial infarction preserved a satisfactory level of physical activity. Conclusion. Received data confirm a presence of an excessive security: prevention of coronary heart disease manifestation and progression in longevity. Long-livers should be considered as a natural model of an antiatherogenic factors and mechanisms.

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Age-dependent dynamics of screening metabolic parameters in long-livers and its biophysical estimation

Summary:

The purpose of the study: to examine age-dependent dynamics of parameters of biochemical screening in long-livers. Material and methods. The study included 201 long-livers divided (Saratov) into two groups: the main group (centenarians) and the control group (90-99 y.o.). Basic parameters of biochemical screening were analyzed. Results. The suited sample of centenarians characterized by significantly lower levels of total cholesterol, triglycerids, glucose and creatinine. All studied parameters progrediently decreased from early long-livers age to centenarians. Maximal rates of age dependencies allowed us to confirm maximal weight of lipids in early longevity and glucose and creatinine in centenarians. Conclusion. All present results are most likely explained by the combined effects of genetic, environmental and "hundred years" factors leading to dynamic remodeling of control systems. Major result of such remodeling is age-dependent optimal level of metabolic factors as a mechanism of successive ageing.

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Cardiovascular disease prevalence and clinical characteristics in Great Patriotic War veterans

Year: 2015, volume 11 Issue: №1 Pages: 023-027
Heading: 70 Years of Victory in the Great Patriotic War Article type:
Authors: Lipatova Т.Е., Denisova Т.Р., Shuldyakov V.A., Alipova L.N., Haybekova T.V., Yuanov A.A.
Organization: Regional Hospital, Regional Hospital for War Veterans, Saratov, Saratov State Medical University
Summary:

Present article summarizes the results of long-term studies of cardiovascular health parameters in war veterans of Saratov region admitted to Saratov regional hospital for war veterans. Cardiovascular disease spectrum and its prevalence dynamics were studied in war veterans. Clinical signs and disease course features of cardiovascular pathology were systematized including Great Patriotic War veterans, who successfully had reached the state of longevity.

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The most important parameters of life quality of the Great Patriotic War veterans

Year: 2015, volume 11 Issue: №1 Pages: 019-023
Heading: 70 Years of Victory in the Great Patriotic War Article type:
Authors: Yuanov A.A., Denisova Т.Р., Shuldyakov V.A., Lipatova Т.Е.
Organization: Saratov State Medical University, Regional Hospital for War Veterans, Saratov, Regional Hospital
Summary:

Purpose of the study was to estimate current state of quality of life of Great Patriotic War veterans. Materials and methods. The study included 368 veterans of the Great Patriotic War according to Federal State "Concerning veterans" #5, 1995. Protocol of the study included adapted fragments of WHOQOL, WHOQOL-Old, SF-36, SIP questioners as well as visually-analog scale of self-assessment of quality of life with further going quality of life index calculations. Re-sults. In the studied sample of the Great Patriotic War (GPW) veterans including long-livers comparably was detected high level of quality of life (QOL) by physical criteria and independence level. It was revealed that QOL by self-service criteria in the GPW veterans was low and extremely variable by other criteria groups. Both ageing and gender influenced upon physical activity, self-service and QOL self-assessment. Women were outstanding by psychological criteria and independence with no association with age group. Conclusion. QOL indication in the GPW veterans of studied sample elucidated a satisfactory level of healthcare in the region, which allows veterans in certain way preserve both physical and psychological health, as well as grounds positive self-assessment of personal position in society and values system according to their life-goals and expectations.

Keywords: quality of life
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