Saratov JOURNAL of Medical and Scientific Research

myocardial infarction

Clinical and immunological aspects of the course of myocardial infarction associated with diabetes mellitus during hospital treatment

Year: 2015, volume 11 Issue: №3 Pages: 287-290
Heading: Internal Diseases Article type: Original article
Authors: Skorodumova Е.А., Kostenko V.A., Siverina A.V., Fedorov A.N.
Organization: Institute for Emergency Medical Care n.a. I.I. Dzhanelidze
Summary:

The aim of the study was to provide the data on the course of myocardial infarction (Ml) associated with diabetes mellitus (DM) in hospital. Material and methods. 102 patients with Ml were included in two cohorts, first with DM, second — without DM. Groups were compatible by gender, age and standard therapy. Results. Angiocoronarography data have revealed that patients of group 1 were characterized by multiple vessels lesion due to "rescue" angioplasty with stenting performed 5 times. Patients with DM demonstrated in-hospital higher rate of both acute (by Killip) and chronic (by NYHA) heart failure of advanced degrees as well as recurrent Ml, early postinfarction angina pectoris, heart rhythm disorders and hematomas due to injections. Conclusion. The previously mentioned results lead to higher mortality in this group. Significant elevation of CRP, interleukin-6 and epidermal growth factor levels proved more activated systemic inflammatory response in patients with Ml and DM playing key role in pathogenesis of complications of the disease.

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Features of medical examination of suitability of employees for working at nuclear power plant after myocardial infarction

Year: 2014, volume 10 Issue: №4 Pages: 805-809
Heading: cardiac surgery Article type: Original article
Authors: Bushmanov A.Yu., Krasnyuk V.I., Korenkov V.V., Metlyaeva N.A., Afonin S.A., Ustyugova A.A.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency, Public Limited Company "Concern "Rosenergoatom"
Summary:

Aim: examination of professional qualification of NPP personnel suffering from post-infarction cardiosclerosis, to work with sources of ionizing radiation with the formation of proposals of amendments to the order of the health Ministry from 12.04.2011 No. 302-N. Material and Methods. Medical database by making indicators with individual registration forms made from 269 persons with postinfarction cardiosclerosis staff of main and auxiliary production of Russian NPPs (272 men and 7 women), average age of the examined patients was 56.2 ± 7.0 years; the total number the analyzed characteristics, reflected in the generated database was 49 lines. Results. The results of the risk stratification of sudden cardiac death with the formation of risk groups and proposed draft amendments to the Order of the health Ministry of the Russian Federation of 12 April 2011 No. 302-n order differential approach to the assessment of competency in hazardous conditions patients with postinfarction cardiosclerosis. Conclusion. On the basis of clinical examination and assessment of risk for sudden cardiac death, it is necessary to make changes in the List of medical contraindications for admission to works in accordance with section 4 of Annex No. 3 to the Order of Ministry of health, April 12, 2011 No. 302 n in terms of access to work with ionizing radiation to persons suffering from post-infarction cardiosclerosis; to identify among patients postpartum cardiosclerosis persons not fit to continue the work in contact with sources of ionizing radiation, it is necessary referral to additional examination in occupational disease Centers in accordance with the Order of Ministry of health, April 12, 2011 No. 302 N.

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Pregnancy associated plasma protein-A in acute coronary pathology.

Year: 2014, volume 10 Issue: №1 Pages: 92-95
Heading: Сardiology Article type: Original article
Authors: Sapozhnikov A.N., Razin V.A., Chernysheva E.M., Gimaev R.Kh., Kajumova G.Kh., Mazurova O.V., Akhmetshina D.I.
Organization: Ulyanovsk State University
Summary:

The aim: to study pregnancy associated plasma protein A as a potential marker of myocardial necrosis with acute coronary syndrome. Material and methods. The rates of PPPP-A and insulin-like growth factor 1 were determined in 24 patients with acute myocardial infarction, in 18 patients with unstable angina and in the control group as well. Results. The rates of PPPP-A and ILGF-1 are accurately higher in the groups with acute coronary pathology in comparison to the patients with no ischemia. Conclusions. PPPP-A proves to be a marker of ischemia and/ or injury and could be used as a diagnostic predictor of an unstable atherosclerotic plaque in acute coronary development.

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Leukocytosis and clinical outcomes in patients with myocardial infarction with ST-segment elevation

Year: 2013, volume 9 Issue: №4 Pages: 673-678
Heading: Сardiology Article type: Original article
Authors: Panina A.V., Dolotovskaya P.V., Puchinyan N.F., Dovgalevsky Ya.P., Furman N.V.
Organization: Saratov Institute of Cardiology, Russia
Summary:

The aim of the study is to evaluate the frequency of occurrence of leukocytosis and its prognostic value for the course and outcome of myocardial infarction with ST-segment elevation. Material and Methods. The study included 245 patients aged 61,2 years, who were on treatment at the Department of Emergency Cardiology with diagnosis of acute myocardial infarction with ST-segment elevation. Results. Leukocytosis (white blood cell levels of more than 10*109/L) was observed in 34,7% of patients. The presence of leukocytosis was associated with increased incidence of congestive heart failure class IV at Killip, ventricular fibrillation and lethal outcomes during hospitalization. There were no significant differences in the incidence of adverse events in the long-term period between the patients with leukocytosis and with normal level of white blood cells. Conclusion. Increased levels of white blood cells (more than 10*109/L) in patients with myocardial infarction with ST-segment elevation is associated with a significantly increase relative risk of cardiogenic shock (Odds ratio 5,2, 95% Cl, 1,7-15,8, p=0.001), ventricular fibrillation (Odds ratio 8,5, 95% Cl, 1,9-38,3, p=0.001) and death during hospitalization (Odds ratio 2,47, 95% Cl, 1,87-38,4, p=0,03). The level of white blood cells on admission to hospital may be used as one of the additional factors predicting the risk of patients with myocardial infarction with ST-segment elevation during hospitalization.

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Chronic oral pathology and ischemic heart disease and its complications

Year: 2013, volume 9 Issue: №3 Pages: 408-412
Heading: Stomatology Article type: Original article
Authors: Ivaschenko Y.Y., Shvarts Y.G., Parkhonyuk E.V., Eremin O.V.
Organization: Saratov State Medical University
Summary:

Objective: to establish the relationship of chronic generalized periodontitis, multiple cavities and dentofacial anomalies with various forms of coronary heart disease and its complications. Material and methods. The study included 294 patients with coronary heart disease and its complications. The patients were divided into two groups. Group I included 89 patients with acute Q-myocardial infarction, which was placed in the presence of at least 2 of the following criteria identified on the basis of a comprehensive clinical and instrumental examination: clinical, laboratory confirmation (CK-MB), electrocardiographic signs of damage or myocardial necrosis. The following statistical methods were used: multi-variate and univariate analysis of variance, non-parametric tests, crosstabulation, chi-square test, Fisher»s exact test. As a measure of variability of the normal distribution standard deviation was used. Results. It is noted that in patients with myocardial infarction more likely than in patients without coronary heart attack in history severe generalized periodontitis, dentofacial anomalies and multiple dental caries have appeared. In patients with acute myocardial infarction, severe periodontal disease has been associated with increased fibrinogen levels in the blood and an increase in the dispersion of the interval QT, which are known to be indicators of poor prognosis in acute coronary disease.

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Comparative analysis of myocardial revascularization methods for ischemic heart disease

Year: 2012, volume 8 Issue: №3 Pages: 756-764
Heading: Internal Diseases Article type: Review
Authors: Sinkeev M.S., Skvortsov Yu.l., Mikhailenko О.A.
Organization: Saratov State Medical University
Summary:

The review of literature is devoted to the comparative analysis of clinical researches of efficiency and frequency of complications after application of surgical and medicamentous methods of treatment of coronary heart disease.

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Objective evaluation of life quality of patients with ischemic heart disease

Year: 2010, volume 6 Issue: №3 Pages: 585-588
Heading: Internal Diseases Article type: Original article
Authors: D.A. Osipov, T.V. Rozhdestvenskaya, I.L. Krom, А.Р. Rebrov
Organization: Saratov State Medical University, Saratov Military Medical Institute, Saratov Institute of Social Education, Head of Centre of Medical and Social Research
Summary:

The article presents the results of studies of life quality of patients with ischemic heart disease and old myocardial infarction. The life quality is considered as an independent and objective multifactor indicator reflecting the status of this category of patients

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Evaluation of five-year risk of lethal outcome and development of cardiovascular disorders in patients with acute myocardial infarction on basis of 0.1-Hz rhythms synchronization in cardiovascular system

Year: 2010, volume 6 Issue: №2 Pages: 328-338
Heading: Internal Diseases Article type: Original article
Authors: KiselevA.R., Gridnev V.I., KaravaevA.S., O.M. Posnenkova., V.I. Ponomarenko., M.D. Prokhorov., B.P. Bezruchko.,V.A. Shvartz
Organization: Saratov National Research University n.a. N. G. Chernyshevsky, Saratov Institute of Cardiology, Russia, Saratov Branch of Institute of Radio Engineering and Electronics n.a. V.A. Kotelnikov
Summary:

The research goal is to evaluate the impact of autonomic heart control indices on five-year risk of lethal outcome and development of cardiovascular disorders in patients with acute myocardial infarction (AMI) and to study the dynam¬ics of indices in short- and long-term period. 125 patients with AMI (42% female), ages 30 to 83 years, were enrolled in prospective observational study. Observation period lasted 6 years. Control checking was carried out in 1 week, 3 weeks, 6 months, 1 year and then annually. The dynamics of heart rate variability (HRV) and the synchronization of 0.1-Hz rhythms of heart and microcirculation (S) were studied during the first year. Outcomes proved to be death, MI, stroke. Development of acute heart failure Killip 2-4 and indices S < 20% during the first week of AMI (х2 = 10,5, p = 0,005 for the Cox model) played a significant role in evaluation of five-year risk of death after AMI. Sensitivity (Se) and specificity (Sp) of index S < 20% during the first week of AMI were 76% and 43% correspondingly. The Cox model showed that indices of HRV and 0.1-Hz rhythms synchronization were not of great value in evaluation of five-year risk of death after AMI. The article concludes that indices S < 20% in patients with AMI possess better prognostic value than common clinical parameters

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EXRIMENTAL AND CLINICAL USING OF CELL TECHNOLOGIES IN CARDIOLOGY

Year: 2006, volume 2 Issue: №3 Pages: 46-52
Heading: Internal Diseases Article type: Review
Authors: Smolyaninov A., Kirillov D., Bulgin D., Kovanko G.
Organization: St. Petersburg Medical University named after academician I.P.Pavlov
Summary:

Heart diseases, and firstly ischemic heart disease and myocardial infarction, cause cardiomyocites death in the way of necrosis and apoptosis. Ability of myocardium to in self-renewing and regeneration is limited, the same way as therapeutically possibilities of prevention it`s remodeling. This loss of cardiomyocites is the leading factor of decrease of pumping function of heart and formation of chronically heart failure and dilated cardiomypathy. Limited ability of human cardiomyocites in proliferation and regeneration can not prevent scar formation and decrease of contractile ability after myocardial infarction. Substitution and regeneration of myocardial structures is significant purpose, it can be reached in the way of stimulation of auto logical cardiomyocites or transplantation of stem cells or skeletal myoblasts. Realization of the fact that myocardium has ability to regenerative process, conditioned in last years generate interest in using stems cells in cardiology. The way of using of stem cells in treatment cardio-vascular disease is aggressively developing in last ten years. In this period experimental outcomes were very convincing, and so this approach start to use in clinical practice.

INFLUENCE OF SEASON PATTERN ON PREVALENCE AND SEVERITY OF ACUTE MYOCARDIAL INFARCTION, FUNCTION OF HEMOSTASIS IN PATIENTS WITH ISCHEMIC HEART DESEASE OF CLIMATE AREA OF MIDDLE VOLGA REGION

Year: 2007, volume 3 Issue: №3 Pages: 68-72
Heading: Internal Diseases Article type: Original article
Authors: O.K. Rybak, A.N. Burlaka, N.P. Ivannikova, A.P. Burlaka
Organization: Saratov Institute of Cardiology, Russia, Saratov State Medical University
Summary:

The aim of this study is to evaluate season pattern, severity and outcome of acute myocardial infarction in dependence of yearly patterns of function of hemostasis in middle Volga Region. Season pattern of prevalence myocardial infarction with winter peak was discovered, be accompanied of increase platelet aggregation, deterioration of blood viscosity, fibrinolysis depression. Most serious clinical course of summer myocardial infarction was observed with prosperity of hemostasis.

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