Saratov JOURNAL of Medical and Scientific Research

pregnancy

Pregnancy and cervical intraepithelial neoplasia

Year: 2019, volume 15 Issue: №1 Pages: 19-23
Heading: Obstetrics and Gynecology Article type: Review
Authors: Yakovleva O.V., Glukhova T.N., Rogozhina I.E., Skupova I.N.
Organization: Saratov State Medical University
Summary:

The review of literature is devoted to the problem of cervical intraepithelial dysplasia in pregnant women. For the analysis, publications in the PubMed from 2013 till 2018 database were used.

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The problem of management of pregnant women with ulcer colitis

Year: 2018, volume 14 Issue: №4 Pages: 629-632
Heading: Internal Diseases Article type: Author's opinion
Authors: Kudishina M.M., Kozlova I.V.
Organization: Saratov State Medical University
Summary:

The relevance of the study of inflammatory bowel diseases in pregnant women is due to the rise of the disease at a young age (20-30 years), which accounts for the period of active childbirth. Treatment of pregnant women with ulcer-ative colitis and Crohn's disease remains a difficult problem for both doctors and patients. This work aims to analyze the features of the course and treatment of ulcerative colitis in pregnant women, to identify problems in the tactics of management on a real clinical example.

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Manifestations of pathomorphosis at pregnant women with heart diseases

Year: 2017, volume 13 Issue: №2 Pages: 233-238
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Kazachkova E.A., Kazachkov E.L., Vorobiev I.V.
Organization: South Ural State Medical University
Summary:

Purpose: to study the structure of heart defects in pregnant women, the features of the medico-social portrait, the course of pregnancy and perinatal outcomes in patients with heart defects in the light of pathomorphosis. Material and Methods. A retrospective clinical and anamnestic analysis of the medical documentation of 165 patients delivered in the maternity hospital of the Municipal Health Care Institution of the City Clinical Hospital No. 6 in Chelyabinsk in 1991-1994 was conducted, (group 1)and a prospective cohort study of 168 patients who were delivered to this hospital between 2011 and 2014 (group 2) in accordance with a modified WHO classification for assessing the risk of cardiovascular complications for the mother and offspring, the characteristics of the medico-social portrait, The course of pregnancy and perinatal outcomes in patients with heart defects in the light of the doctrine of pathomorphosis. Results. It is established that over the past 20 years, there have been significant changes in the structure of heart diseases, the medical and social characteristics of patients with this disease, complications of gestation, which must be taken into account when choosing the optimal tactics for pregravid preparation, pregnancy in women with heart defects. Conclusion. The significant changes in the structure and frequency of heart defects observed in modern pregnant women with heart defects, in the features of the medical and social portrait of these patients, and also during pregnancy, childbirth and perinatal outcomes, can be treated as pathomorphosis in the clinical (narrow) sense.

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Assessment of hemodynamic parameters of uterus during physiological pregnancy

Year: 2015, volume 11 Issue: №2 Pages: 151-156
Heading: Radiology Article type: Original article
Authors: Chekhonatskaya M.L., Petrosyan N.O.
Organization: Saratov State Medical University
Summary:

The aim of the article is to analysis of the hemodynamic parameters of the uterus and cervix during the second and third trimesters of pregnancy. Material and methods. It was conducted dynamic ultrasound in 240 women with physiological course for singleton pregnancies in the period from 12 weeks of gestation until term labor. Results. For the second trimester of pregnancy redistribution of total uterine blood flow in the direction of increasing blood flow in more of the body than the cervix has been considered to be typical. From the third trimester of pregnancy until term labor a significant increase of blood supply to the cervix has been found; there has been a tendency to increase the capacity of the vascular channel and the reduction in peripheral resistance vessels of cervix. Conclusions. Early detection of disorders of uterine and cervical hemodynamics allows to predict the occurrence of various pathological conditions.

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Pharmacometrics as an instrument of clinical pharmacology for optimization of drugs dosing regimens during pregnancy

Year: 2014, volume 10 Issue: №1 Pages: 199-203
Heading: Parmacology Article type: Review
Authors: Reshetko O.V., Lutsevich К.А.
Organization: Saratov State Medical University
Summary:

Changes in maternal physiology and metabolic during pregnancy influence pharmacokinetics and illustrate that standard adult dosing is likely to be incorrect during pregnancy. Different pharmacometric approaches are available for design and analysis of clinical studies during pregnancy. Physiologically-based pharmacokinetic (PBPK) model could be used to evaluate different dosing regimens for pregnant women and serves in predicting drug exposure and response at the personal level.

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Molecular and cellular mechanisms of destabilization of membranes and prenatal discharge of amniotic fluid

Year: 2013, volume 9 Issue: №4 Pages: 644-648
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Mikhaylov А.V., Dyatlova L.I., Chesnokova N.P., Ponukalina Е.V., Glukhova T.N.
Organization: Perinatal Centre, Saratov , Saratov State Medical University
Summary:

Purpose: to establish the role of activation of lipid peroxidation and antioxidant deficiency of blood and amniotic fluid in the destabilization of membranes with early prenatal discharge of amniotic fluid. Material and methods. The analysis of lipid peroxidation products content in blood and amniotic fluid — diene conjugates (DC), malondialdehyde (MDA) and the quantitative determination of total peroxides (OxyStat), the estimation of the total antioxidant status (TAS), the activity of SOD and the content of ceruloplasmin in 20 pregnant with premature rupture of membranes in the gestation period of 22-34 weeks, were hospitalized at the Department of Pathology of Pregnancy of Saratov Perinatal Center in 2012. DC and MDA determination was carried out by conventional spectrophotometric methods of research, quantitative determination of peroxides (OxyStat) was carried out by enzyme immunoassay analyzer «Alfa Prime» («Meredith Diagnostics», 2008 using chemicals made by the company «Bender Medsystems»). The study of antioxidant status of serum and amniotic fluid was performed by enzyme immunoassay analyzer «Alfa Prime» («Meredith Diagnostics», England, 2008). Reagents («Bender Medsystems», Austria) were used to determine the total antioxidant status (TAS) and the SOD activity. To assess the content of ceruloplasmin reagent «Sentinel» (Italy) was used. Results. Indicators of lipid peroxidation in blood and amniotic fluid and anti-radical protection of biological membranes of cells and body fluids in the "mother-placenta-fetus" increased. Conclusion. Systemic activation of lipid peroxidation has been proved to be a
pathogenetic factor in the failure of membranes in prenatal discharge of amniotic fluid. The increase in the blood levels of lipid peroxidation products on the background of the activation of antioxidant system is considered as a prognostic sign of abortion.

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Risk factors of development of inflammatory diseases of parodentium in pregnant women

Year: 2013, volume 9 Issue: №3 Pages: 383-386
Heading: Stomatology Article type: Original article
Authors: Dubrovskaya M.V., Eremin O.V., Savina Е.А., Ivashchenko Y.Y., Minasyn A.M.
Organization: Saratov State Medical University
Summary:

Pathogenesis of oral hygiene, smoking, gestosis, immunosuppression and cytokine disbalance affect inflammatory periodontal diseases in pregnant women. The research goal is to study clinical and immunological features of parodentium and cytokine profile in oral cavity of pregnant women. Material and methods: The condition of parodentium tissues was studied at 240 women with physiological pregnancy and 360 with pregnancy complicadet by gestosis. Re-sults: Freguency and character of inflammatory periodontal diseases in pregnancy were defined. Immune and cytokine disbalance contributed greatly to pathogenesis of inflammatory periodontal diseases at pregnant women. Conclusion: Violations of immune homeostasis at the pregnancy, complicated gestosis, authentically are more expressed that contributes to the development of gingivitis and periodontal disease. The imbalance of cytokines can serve in oral liquid as additional diagnostic and predictive marker of severity of a course of inflammatory periodontal disease.

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Influence of pregnancy course peculiarities on formation of fetal testicles

Year: 2013, volume 9 Issue: №2 Pages: 234-240
Heading: Obstetrics and Gynecology Article type: Review
Authors: Chekhonatskaya M.L., Vasilevich L.K., Bondarenko N.A.
Organization: Saratov State Medical University
Summary:

The review gives some of morphological, metrical, hormonal and biochemical parameters of antenatal ontogenesis of fetus testicles and newborns depending on pregnancy pathology and childbirth. Comparative analysis was carried out. Risk factors of development of morphological changes in fetus testicles and newborns from mothers with normal and pathological course of pregnancy were presented.

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Changes in the cytokine profile of patients blood with premature rupture of amniotic membranes and their pathogenic significance

Year: 2013, volume 9 Issue: №2 Pages: 224-229
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Mikhaylov А.V., Dyatlova L.I., Chesnokova N.P., Ponukalina E.V., Glukhova T.N.
Organization: Saratov State Medical University, Perinatal Centre, Saratov
Summary:

Purpose: Pathogenetic study of new diagnostic and prognostic criteria for evaluation of pregnancy in terms of the cytokine profile of blood. Materials and methods: The analysis of anti-inflammatory and pro-inflammatory cytokines in the blood of 50 pregnant women with preterm rupture of membranes in gestation of 22-34 weeks, who were treated at the Department of Pathology in pregnancy of Saratov Perinatal Center in 2012, was performed. The method of enzyme linked immunosorbent assay using test systems «Vector— Best» (Novosibirsk, Russia). Results:.Clinical and laboratory examination revealed an increase levels of IL-1(3, IL-2, IL-6, IL-8, TNF-a, while reducing the content of IL-4, IL-10 in blood. Conclusion: Manifest signs of possibility of prenatal rupture of membranes and premature labour in 22-34 weeks gestation are combined with increasing of IL-1(3, IL-6, IL-8, TNF-a, IL-2 and with decreasing of IL-10, IL-4 level in the blood, which indicates the need for monitoring the content of these cytokines in the blood for the diagnosis and prognosis of pregnancy.

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Risk factors of intestinal obstruction in pregnancy

Year: 2012, volume 8 Issue: №3 Pages: 723-728
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Khvorostukhina N.F., Salov I.A., Rogozhina I.E., Stolyarova U.V.
Organization: Saratov State Medical University
Summary:

Objective: to study risk factors and options for clinical course of acute intestinal obstruction in pregnancy. Materials and methods. A detailed study of history, clinical course, diagnosis and treatment characteristics of acute intestinal obstruction in 79 pregnant women was undertaken. Results: It was determined that a combination of intestinal obstruction, and pregnancy is more common for II and III trimester of gestation (88,5%), with more likely to develop mechanical obstruction caused by the adhesive process (77,2%). Risk factors for intestinal obstruction in pregnancy are: chronic diseases of gastrointestinal tract, surgery of abdominal cavity and pelvis, burdened obstetric and gynecological history and long-term use of progestogens during pregnancy. Difficulties in diagnosis are associated with absence of classical symptoms of disease that is caused by changes in topographical relations of abdominal cavity, increasing size of uterus, as well as lack of immune response to the emergence of a pathological process. Conclusion. Formation of pregnant women at risk for development of intestinal obstruction and preventive measures to address violations of intestinal motor function can reduce the risk of disease. Algorithm of medical tactics for suspected acute intestinal obstruction in pregnancy, allowing to reduce time of diagnosis and provision of medical care.

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