Saratov JOURNAL of Medical and Scientific Research

№4

Platelet indices as markers of platelet turnover and aggregation: pathophysiological interpretation, clinical impact, perspectives in research

Year: 2017, volume 13 Issue: №4 Pages: 813-820
Heading: Internal Diseases Article type: Review
Authors: Malinova L.I., Furman N.V., Dolotovskaya P.V., Puchinyan N.F., Kiselev A.R.
Organization: Saratov State Medical University n.a. V.I. Razumovsky Research Institute of Cardiology
Summary:

The purpose of the review is to characterize existing in open access bibliographical databases such as eLibrary and PubMed evidence on clinical impact of morphometric platelet indices as markers of platelet aggregation ability and turnover as a methodology and theoretical framework of further investigation. Studies results were pooled from open access bibliographic databases (eLibrary, and PubMed) according to modified PRISMA algorithm. Relevant studies were identified by systematic searches of the original studies published during the last 10 years in the Russian and English languages. Results of 96 original studies in accordance with inclusion criteria were published during the last 10 years in scientific journals indexed in eLibrary, and PubMed. The majority of publications (64.58%) consist of evidence pro diagnostic and prognostic significance of platelet indices. Studies demonstrating the significance of platelet indices as possible risk markers of thrombotic events in cardiovascular patients were predominating among "pro" publications. In 15.63% published results contradict concept of platelet indices usefulness as diagnostic and prognostic markers in clinical practice. Morphometric platelet indices can be considered as useful diagnostic and prognostic markers of thrombotic events in cardiovascular patients. Existing gaps in evidence suggest the need of further investigations.

AttachmentSize
2017_04_813-820.pdf482.16 KB

Peculiarities of clinical course of gastroesophageal reflux disease in patients with type 2 diabetes and obesity

Year: 2017, volume 13 Issue: №4 Pages: 809-812
Heading: Internal Diseases Article type: Original article
Authors: Andreeva E.l.
Organization: Stavropol State Medical University
Summary:

Aim: to study the clinical course of gastroesophageal reflux disease (GERD) in patients with type 2 diabetes and evaluation of the parameters of the esophagus 24-hour pH-metry. Material and Methods. In the examination of patients with GERD, three groups of patients were selected for 50 people each. The first group includes patients with GERD with combined course of obesity and type 2 diabetes (mean age 54.6±2.73 year; 32 females and 18 males). The second group included patients with GERD against obesity (mean age 42.3±2.11 year; 30 females and 20 males). The control group consisted of patients with GERD without excess body weight and concomitant pathology (average age43.6±2.11 year; 29 females and 21 males). In addition to collecting complaints and anamnesis, the patients and the control group underwent a 24-hour pH-metric study of the esophagus according to a conventional method. Results. Patients suffering from GERD in the background of type 2 diabetes have a clinically asymptomatic or asymptomatic course; there is a significant increase in the daily pH-metry, indicating a more pronounced nature of the changes. Conclusion. Patients suffering from GERD in the background of type 2 diabetes require a comprehensive examination of the upper digestive tract to identify GERD, even if there are no complaints characteristic of the disease.

AttachmentSize
2017_04_809-812.pdf445.56 KB

Interdisciplinary aspects of rehabilitation of patients with oncological diseases in non-terminal situation of the disease

Year: 2017, volume 13 Issue: №4 Pages: 806-808
Heading: Health Service Organization Article type: Review
Authors: Shmerkevich А.В., Vodolagin A.V., Balakina D.D.
Organization: Saratov State Medical University
Summary:

Medical social rehabilitation of patients with oncological diseases in the non-terminal stage of the disease is based on the principle of an interdisciplinary approach, which involves complex special treatment, providing patients and their families with various types of social and psychological support at all stages of specialized care. The authors of the review consider the solution of medical and social problems in the rehabilitation of patients with oncological diseases in the context of the synergistic effect. Weak social and psychological protection of patients with oncological pathology adversely affects the prognosis of the disease and worsens patients quality of life. The review provides evidence that patients who receive social support are best adapted to the cancer situation, while a lack of social support is a significant risk factor for increased mortality in cancer patients.

Keywords: quality of life
AttachmentSize
2017_04_806-808.pdf225.19 KB

The role of health centers in preventive care provision

Year: 2017, volume 13 Issue: №4 Pages: 803-805
Heading: Health Service Organization Article type: Original article
Authors: Shemetova G.N., Sidorova N.V., Gubanova G.V.
Organization: Saratov State Medical University
Summary:

Aim: to assess the importance of the Centers of Health in the organization and provision of preventive care to the population, in the early detection of risk factors for the development of chronic non-communicable diseases and the development of a healthy lifestyle. Material and Methods. On the basis of the Health Center of Engels Center for Medical Prevention in the Saratov Region, the detection of risk factors for 2011-2015 was analyzed according to statistical reporting (form No. 68) and health cards (form025-CZ/y) of 207 patients. To assess the satisfaction of visitors with the work of the Center, a specially developed questionnaire was conducted, which included 22 questions that characterize the patient profile, his attitude to the organization and the results of the survey, and the motivation to modify the way of life. Results. The study confirmed the important role of the Centers of Health in the organization and provision of preventive care to the population, the formation of a healthy lifestyle and the early detection of diseases and risk factors for their development. Conclusion. Only joint efforts of medical institutions, authorities, educational organizations, mass media can lead to the formation of the population's responsibility for their health and readiness to modify the way of life.

AttachmentSize
2017_04_803-805.pdf212.86 KB

Analysis of activity of health workers in educational organizations and needs for medical care of children with disabilities

Year: 2017, volume 13 Issue: №4 Pages: 800-802
Heading: Health Service Organization Article type: Original article
Authors: Fomina A.V., Grigorieva N.A., Shovkun N.V.
Organization: Peoples' Friendship University of Russia
Summary:

Objective: study of the current state of medical support for children in educational organizations and an assessment of the needs of children with disabilities in medical care. Material and Methods. According to the results of the sociological survey (1796 profile views), the analysis of the health workers' activities in educational organizations implementing the adapted basic general education programs was carried out. According to the preventive examination of children with disabilities (124 people) and of the survey of parents (124 profile views), the article assesses the effectiveness of preventive work with children and parents to strengthen the dental health of schoolchildren in Moscow. Results. The majority of medical workers in educational institutions implementing adapted basic general education programs are represented by specialists with secondary medical education (77.2%). Among specialists needed in educational organizations, dentist is often called. The need for children with disabilities in dental care is confirmed by data obtained during the study of dental health of children with hearing impairment and children with visual impairments. Conclusion. One of the areas of medical care for children with disabilities in educational organizations is active monitoring of the health of children and the implementation of comprehensive preventive measures, which requires the involvement of more health workers.

AttachmentSize
2017_04_800-802.pdf228.58 KB

Rehabilitation after hip and knee joints replacement: several results of medical and sociological monitoring

Year: 2017, volume 13 Issue: №4 Pages: 796-799
Heading: Health Service Organization Article type: Original article
Authors: Fedonnikov A.S., Andriyanova Е.А., Erugina M.V, Norkin I.A.
Organization: Saratov State Medical University
Summary:

Aim: research of rehabilitation process problem areas after hip and knee joints replacement. Material and Methods. Program of monitoring and evaluation of medical, organizational, social and psychological components of rehabilitation was developed. Sociological study of 1175 patients who have undergone in 2015-2016 total hip and knee joints replacement was conducted. Results. It was revealed an absence of real interaction between key parties of rehabilitation processes based on significant disproportion between high level (more than 80%) of patients' satisfaction of rehabilitation organizing and low activity of health managers (9.4%). Despite of declared patients' high rehabilitation quality permanent pain noted by 45% of respondents, move freely without additional support is available only for about 50% of patients. Conclusion. Rehabilitation management and its' quality are the key values for locomotor system functional recovery. Provided study has designated main problems of rehabilitation quality evaluation after hip and knee joints replacement.

AttachmentSize
2017_04_796-799.pdf425.75 KB

Special cooling liquid and its practical application in sport medicine

Year: 2016, volume 12 Issue: №4 Pages: 721-726
Heading: sports medicine Article type: Review
Authors: Rasinkin S.M. Petrova V.V., Konovalov D.P., Bragin M.A.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency, Ltd. "MontClinic"
Summary:

The purpose of this study is to explore special cooling liquid in sports. We can predict the decrease in body temperature, reducing dehydration and increasing endurance using this liquid. Finally, special cooling liquid improves physical activity at high temperatures.

AttachmentSize
2016_04-1_721-726.pdf761.76 KB

Transarterial chemoembolization for primary and metastatic liver tumors

Year: 2016, volume 12 Issue: №4 Pages: 716-720
Heading: Oncology Article type: Review
Authors: Popov M.V., Aronov M.S., Voskanyan S.E., Karpova O.V.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

The literature review presents the methodology of transarterial chemoembolization (TACE) — widely used method of treatment of primary and secondary liver tumors. The TACE role as a neoadjuvant therapy and the role in the management of unresectable primary and secondary liver tumors are shown. The morphofunctional basis of TACE, benefits of superselective intra-arterial administration of cytostatic agents especially in combination with ischemic impact on a tumor are described. The subject of the choice of the chemotherapeutic agent is also touched; modern drug-loaded microspheres which allow the use of higher doses of the chemotherapeutic drug without increasing systemic effect and prolong its effect on tumor are described. Lack of correlation of presence and severity of a post-embolization syndrome with success of the procedure is noted.

AttachmentSize
2016_04-1_716-720.pdf254.88 KB

Role of a preoperative distal and proximal embolization of the right branch of the portal vein at surgical treatment of a liver malignant tumors

Year: 2016, volume 12 Issue: №4 Pages: 713-716
Heading: Oncology Article type: Original article
Authors: Popov M.V., Voskanyan S.E., Aronov M.S., Karpova O.V.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

Objective: assessment of safety and efficiency of application of the method of the distal and proximal embolization of the right branch of a portal vein using an occluder for preventive increase of the small future remaining liver amount in case of the planned resection. Material and methods. In the Burnazyan Federal Medical Biophysical Center that method was used in two cases: metastasises of bladder cancer in one case and of colorectal cancer in second case. Patients were males aged 57 and 64. Measuring the amount of future remaining liver volume was carried out with the CT-volumetry. Portal vein embolization of the right branch was carried out by transhepatic ipsilateral access using polyvinyl alcohol particles and occluder AVP II. Results. As a result in both cases the gain (9 and 24%), sufficient for performance of a resection, of the remaining liver volume was noted; the progression of the tumor process and periop-erative complications were not observed. Conclusion. Distal and proximal preoperative portal vein embolization is an effective and promising method, allowing surgeons to increase the number of operable patients and reduce the risk of postoperative liver failure.

AttachmentSize
2016_04-1_713-716.pdf719.65 KB

Pain syndrome features in Parkinson's disease

Year: 2016, volume 12 Issue: №4 Pages: 706-712
Heading: Neurology Article type: Review
Authors: Bril Е.М., Udalov U.D., Anikina M.A., Zimnyakova O.S.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

Pain in Parkinson disease take the special place among all of disease symptoms due to it pathogenetics and clinical diversity. In spite of the plurality of resent studies, the majority of clinical practioners and neurologists didn't pay attention to significant decline of the quality of life in patients with Parkinson disease and pain disorders. This article was created with aim to summarize all important results of studies, focused on pain pathogenesis and clinical features on different stages of disease.

AttachmentSize
2016_04-1_706-712.pdf319.5 KB