Saratov JOURNAL of Medical and Scientific Research


Assesment of mineral metabolism in patients with HIV-infection, chronic hepatitis с and co-infection HIV/ chronic hepatitis С

Year: 2014, volume 10 Issue: №4 Pages: 617-622
Heading: Infectious Diseases Article type: Original article
Authors: Yurko Е.М.
Organization: Kharkov National Medical University

Research Objective: Evaluate the indicators of mineral metabolism in HIV-infected patients, patients with chronic hepatitis С and co-infection HIV/HCV. Material and Methods: The content of microelements (zinc (Zn), copper (Cu), iron (Fe)) in serum was determined by atomic absorption spectrophotometry. The study involved 99 patients: with chronic hepatitis С — 32 patients, with HIV infection — 34 and co-infection of HIV/HCV — 33 patients. Results: Microelements and metal-dependent proteins metabolic disorders as a reduction of the zinc, haptoglobin contents, and an increase of copper, iron, and ceruloplasmin contents were identified in patients with chronic hepatitis С In HIV-infected patients and patients with co-infection HIV/HCV were identified reducing zinc, copper, iron, haptoglobin, ceruloplasmin. in patients with co-infection HIV/HCV compared HIV-infected patients lower zinc, haptoglobin, ceruloplasmin contents (p

2014_04_617-622.pdf586.7 KB

Microelement content of bone tissue in transosseous osteosynthesis by II-izarov technique in high-altitude destinations (experimental research

Year: 2014, volume 10 Issue: №1 Pages: 119-123
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Erokhin A.N., Isakov B.D., Nakoskin A.N.
Organization: Bishkek State Medical Academy, Russian Ilizarov Scientific Center «Restorative Traumatology and Orthopaedics»

Aim: To study the redistribution of microelements in bone tissue in osteosynthesis in high-altitude destinations. Material and Methods. The study was performed on 72 mongrel dogs of both sexes aged 1-3 years, weighing 10—15 kg. 32 dogs have been experienced the extended leg in lowlands destinations, another group of 32 animals have been experienced elongation produced in high-altitude destinations. The control group consisted of 8 healthy dogs of low mountain areas. The standard technique of surgery has been used in the research. Microelement composition has been studied by atomic absorption spectrophotometer AAS-1 N (Germany) in the long bones and the distraction regenerate. Shapiro —Wilk test was applied to analyze the normality. The data evaluation has been done by Student's t-test for unpaired samples. Results. Calcium and microelement imbalance has been obtained during transosseous osteosynthesis in high-altitude destinations, which causes functional changes in the musculoskeletal system, with similar clinical picture of Kashin — Beck. In the conditions of high-altitude destinations elongation of bones causes changes in microelements in the distraction regenerate. Conclusion. During distraction osteosynthesis in high-altitude destinations phase changes of microelements have been formed in the bone regenerate, which prognoses physiologically the formation of a false joint.

2014_01_119-123.pdf388.02 KB

Level of circulating cytokines and microelements in patients with hemorrhagic fever accompanied by renal syndrome

Year: 2011, volume 7 Issue: №4 Pages: 863-865
Heading: Infectious Diseases Article type: Short message
Authors: Khasanova G.M.
Organization: Bashkir State Medical University of the Russian Health Care

The research goal is to examine the interrelation of cytokines level (INF-y, TNF-a, IL-2, IL-4, IL-10) and concentration of microelements in blood of patients with hemorrhagic fever accompanied by renal syndrome. 292 patients aged 18-59 years have been examined.Enzyme immunodetection has been carried out by using reagents from «Vector-Best» (Novosibirsk). The content of microelements in blood plasma has been estimated by mass spectrometry with inductively coupled plasma (ICP-MS; Elan-9000, PerkinElmer, USA) and atomic emission spectrometry with inductively coupled plasma (ICP-OES; Optima-2000 DV, PerkinElmer, USA). A direct correlation between zinc, selenium, the level of IL-2 and lead, aluminum, the level of TNF-a has been found out. The negative correlation between aluminum concentration and the level of IF-y has been determined

201104_863-865.pdf241.68 KB