Saratov JOURNAL of Medical and Scientific Research

Durnova N.A.

Saratov State Medical University n.a. V. I. Razumovsky, Head of Department of Biology, Pharmacognosy and Botany, Assistant Professor, Doctor of Biological Science

Principles of education of students at a highe medical school

Year: 2018, volume 14 Issue: №3 Pages: 457-460
Heading: Pedagogics and Education Article type: Short message
Authors: Bugaeva I.O., Andronova Т.А., Durnova N.A., Berezutsky M.A., Sheremetyeva A.S.
Organization: Saratov State Medical University
Summary:

The article considers the issues of organization of the educational process at the Department of General Biology, Pharmacognosy and Botany of Saratov State Medical University named after V. I. Razumovsky. The most important component of the educational process at higher schools is education. Teaching and educational process at the department is carried out with the observance of the basic principles of didactics. The analysis of the main directions of educational work is carried out: professional, civil and patriotic, moral, cultural and aesthetic, ecological, medical-prophylactic (promotion of healthy lifestyle) and supervision.

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Antimicrobial activity of herbal extracts from Sedum maximum (L.) Hoffm., Sedum telephium L. received by different methods

Year: 2017, volume 13 Issue: №2 Pages: 213-216
Heading: Microbiology Article type: Original article
Authors: Raikova S.V., Durnova N.A., Prikhodko V.V., Nemolyaeva E.K., Plastun V.O.
Organization: Saratov State Medical University
Summary:

The main goal of investigation was antimicrobial activity of herbal extracts from Sedum maximum (L.) Hoffm., Sedum telephium L. received by different methods. Material and Methods. Extractions from the purification of S. maximum (L.) Hoffm. and S. telephium L. obtained by different methods were the object of study. Staphylococcus aureus ATCC 6538P, Pseudomonas aeruginosa ATCC 27835, Escherichia coli ATCC 25922, Candida albicans ATCC 13108 were used as test cultures. Results. The minimum inhibitory concentrations of the investigated flavonoid-containing aqueous solutions of alcohol extracts of the purification were determined for the following test cultures: S. aureus, P. aeruginosa, E. coli. Conclusion. The antibacterial effect of the studied extracts on all strains of bacteria taken in the experiment was detected. The action is most pronounced in relation to S. aureus. Antimycotic activity was not detected.

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The study of antimicrobial activity of stonecrop extracts (Sedum maximum (L.) Hoffm., S. telephium I.)

Year: 2013, volume 9 Issue: №4 Pages: 640-643
Heading: Microbiology Article type: Original article
Authors: Plastun V.0., Raikova S.V., Durnova N.A., Shub G.M., Komarova E.A.
Organization: Saratov State Medical University
Summary:

The purpose of the work is to investigate the antimicrobial activity of aqueous alcoholic extract of large stonecrop and purple stonecrop. Material and Methods. The effects of large stonecrop (Sedum maximum (L.) Hoffm.) and purple stonecrop (S. telepium L.) on aqueous solution of alcoholic extracts on Staphylococcus aureus АТС С 209R, Pseu-domonas aeruginosa ATCC 27835, Escherichia coli ATCC 25922 have been studied by the method of double serial dilution followed by seeding on solid culture media. As a result of the work the minimum inhibitory concentrations for all extracts to all the studied cultures have been found. Stonecrop extracts have bactericidal action. Conclusion. Antimicrobial activity has been determined for the extracts of both species for all researched samples of microbial strains.

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Internal organs morphology and tumors in laboratory rats with transplanted liver cancer PC-1 by oral intoduction containing extract of Gratiola (Gratiola Officinalis L.) and Anthocyan Maize (Zea Mays L.)

Year: 2013, volume 9 Issue: №2 Pages: 213-220
Heading: Macro- and Micromorphology Article type: Original article
Authors: Navolokin N.A., Polukonova N.V., Maslyakova G.N., Bucharskaya А.В., Durnova N.A.
Organization: Saratov State Medical University
Summary:

The purpose of the work is to study antitumor activity of flavonoid-containing extracts of anthocyan maize and gratiola in experiments in vivo and to estimate their effects on the internal organs, tumors and blood of rats with transplanted liver cancer PC-1. Materials and methods: Effect of extracts of anthocyan maize and gratiola has been studied in experiments in vivo in 30 laboratory rats with transplanted liver cancer PC-1 using morphological and biochemical methods. Results: It has been found that extract of gratiola received by a certain way has selective cytotoxic effect on tumor cells. Anthocyan maize extract reduces endogenous intoxication. Conclusion: These results open the prospect of further study of the extract of gratiola in various experimental models of cancer and anthocyan maize extract use may be developed as a means of endogenous intoxication reducing for application in the treatment of cancer. Investigation of anthocyan maize extract may assist in the development of drugs that reduce the endogenous intoxication at the treatment of cancer.

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Cytogenetic effects of orthopedic constructions

Year: 2012, volume 8 Issue: №2 Pages: 300-304
Heading: Stomatology Article type: Original article
Authors: Polukhina N.V., Durnova N.A., Konnov V.V., Salnikov V.N., Salnikova S.N., Scheremetjeva A.S.
Organization: Saratov State Medical University, Chief Research Assistant
Summary:

Research objective: To estimate cytogenetic effect of dentures on the condition of buccal epithelium by means of the micronuclear test. Materials and methods: For this test the most convenient object of the research is nonkeratinized stratified epithelium which has been taken from 24 patients before prosthetics. Statistical data processing has been done by means of a package of statistical programs «Stadia». Results: The increase in frequency of occurrence of cells with micronuclei in buccal epithelium in patients after the prosthetics that testifies to stability disturbance of genetic material in the studied cells. Influence of fillings and dentures has been revealed. Conclusion: It allows to apply safe materials in stomatology, having reduced their side effects on an organism as a whole

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Antimicrobial activity of peppermint essential oil (Mentha piperita L.)

Year: 2011, volume 7 Issue: №4 Pages: 787-790
Heading: Clinical Pharmacology Article type: Original article
Authors: Raikova S.V., Golikov A.G., Shub G.M., Durnova N.A., Shapoval O.G., Rakhmetova A.Yu.
Organization: Saratov State Medical University
Summary:

Рurposе. To study antimicrobial activity of fume of the essential oil of peppermint against gram-positive and gram-negative bacteria. Materials and methods: The screening study of antimicrobial activity of solutions of essential oil by disk-diffusion method and activity of essential oil fume of own preparation and pharmaceutical form of oil according to standard strains of Staphylococcus aureus, Pseudomonas aeruginosa, Esсherichia coli and 12 clinical strains of staphylococci (6 methicillin-resistant and 6 methicillin-sensitive) has been carried out. Results: Essential oil of own preparation and pharmaceutical form showed equal antimicrobial activity against strains of staphylococci. Essential oil of own preparation has been determined to reveal higher activity against gram-negative strains. Conclusion: Received data have proved the presence of antimicrobial activity against all strains of microorganisms and mostly against staphy-lococci

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