Saratov JOURNAL of Medical and Scientific Research

Skin Diseases

Effciency of acne therapy with small doses of systemic retinoids

Year: 2012, volume 8 Issue: №2 Pages: 600-603
Heading: Skin Diseases Article type: Original article
Authors: Bakulev A.L., Kravchenya S.S.
Organization: Saratov State Medical University
Summary:

The study aimed to research an effciency and safety of isotretinoin usage in small doses in patients with recurrent acne of moderate severity. Materials and methods 40 patients (18 – 27 years) with acne were examined (25 women). All of the patients have had different therapy earlier. To estimate the severity and prevalence of the disease Acne Dermatology Index (ADI) was used. All the patients were ordered isotretinoin (Roaccutane) at a standard dose of 10 mg per day for 3 months. Concentrations of triglycerides, cholesterin, ALT and AST in blood serum have been researched before and during the isotretinoin therapy. After 3-months isotretinoin monotherapy there was a prospective 6-months observation. There have been 40 healthy people examined in a control group. Results. After 3 months of isotretinoin therapy comedones, papules, pustules disappeared in most of the patients, ADI ran to 0,6±0,01 (р<0,001). Isotretinoin in the whole is tolerable, side effects were minimal. By the end of a 3-months therapy laboratory ranges (AST, ALT, triglycerides, etc.) have become comparable with control parameters. Conclusion. Small doses of isotretinoin can quickly solve the problem of an eruption in patients with acne of moderate severity, prevent a recurrence, minimize side effects risk.

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Topical therapy in patients with microbial eczema

Year: 2012, volume 8 Issue: №2 Pages: 596-600
Heading: Skin Diseases Article type: Original article
Authors: Bakulev A.L., Kravchenya S.S., Murashkin N.N., Igonina I.A., Yepifanova A.U., Slesarenko N.A.
Organization: Saratov State Medical University
Summary:

The study aimed to display that clinical and microbiologic research of patients with microbial eczema. The study revealed that the usage of co — formulated medication Supirocin — B was rather effcient, it promotes statistically authentic reduction of eczematous foci with pathogenic St.aureus and Str.spp. Besides, it has strong anti — infammatory effect and reduces eczematous process.

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Possibilities of modern photography in dermatology practice

Year: 2012, volume 8 Issue: №2 Pages: 592-595
Heading: Skin Diseases Article type: Author's opinion
Authors: Alipov N.V., Reshetnikova E.M., Eremina M.G., Galkina E.M., Utz S.R.
Organization: Saratov State Medical University
Summary:

The purpose of the article was to research necessary conditions for creating high — quality images which allow to display all features of pathological process on skin more complete and authentically. That is also an integral part of modern dermatology. The usage of photographic documentation is necessary to improve students’ training, for doctor’s practical activities using the experience of the clinic, creating medical literature, and it is a unique and valuable contribution to diagnostics of dermatological diseases.

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The сentenary of Saratov dermatology and venerology school (1912 – 2012)

Year: 2012, volume 8 Issue: №2 Pages: 585-592
Heading: Skin Diseases Article type:
Authors: Utz S.R., Zavyalov A.I., Slesarenko N.A., Bakulev A.L.
Organization: Saratov State Medical University
Summary:

The history of Skin and Venereal Diseases Department, Saratov State Medical University, opened in September 1912, stages of its establishment and the history of creation of scientifc school are presented in the article.

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The clinical efficacy of extracorporeal and intravascular hemocorrection methods in psoriasis

Year: 2012, volume 8 Issue: №1 Pages: 081-084
Heading: Skin Diseases Article type: Original article
Authors: Baityakov V.V., Kurkina V.A.
Organization: Mordovian State University
Summary:

Purpose. The study of the influence of extracorporeal and intravascular hemocorrection methods (plasmapheresis, ultraviolet blood radiation, ozonetherapy and its combination) on skin process and life quality in patients with extensive psoriasis. Methods. 253 patients with extensive psoriasis from the age of 18 to 72 have been investigated. PASI (Psoriasis Area and Severity Index) and dermatological index of life quality (DILQ) have been used for treatment assessment. Results. The inclusion of efferent quantum and ozone therapy methods in the complex treatment of psoriasis has promoted to the more rapid and complete positive dynamics of skin process and the improvement of life quality. The use of plasmapheresis and its variations with photomodification or the ozone treatment of returning erythrocyte suspension has been the most effective. Plasmapheresis and its modifications are appropriateto be used in the complex treatment of the patients with severe forms of psoriasis. Conclusion: Further study of efferent quantum and ozone therapy methods and their wider use in psoriasis therapy and other chronic dermatosis seem to be promising.

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Clinical and epidemiological signs of scabies and modern methods of diagnostics and treatment (review)

Year: 2011, volume 7 Issue: №3 Pages: 636-641
Heading: Skin Diseases Article type: Review
Authors: Utz S.R., Zavialov A. I., Marchenko V.M.
Organization: Saratov State Medical University
Summary:

The research work provides summary on diagnostics and treatment of scabies. Russian and foreign medical literature has been analyzed. Modern situation of epidemiology, different clinical forms of scabies and some cases of non-effective treatment have been considered

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The peculiarities of the metabolism processes in patients with the exacerbation of extensive psoriasis

Year: 2011, volume 7 Issue: №3 Pages: 633-636
Heading: Skin Diseases Article type: Original article
Authors: Baityakov V. V.
Organization: Mordovian State University
Summary:

Purpose. The study of some indices of the metabolism in patients with the exacerbation of extensive psoriasis, the investigation of the revealed disorder dependence on the clinical peculiarities of the disease and anamnesis data. Methods. 253 patients with extensive psoriasis from the age of 18 to 72 have been investigated.Some indices of lipid and protein metabolism, medium molecular peptide content, lipid peroxidation and antioxidant protection processes in blood plasma have been studied. Results. Dysproteinemia, the increase of С — reactive protein level, seromucoid, medium molecular peptides, common lipids, triglycerides, the reduction of the level of lipid proteins of high density, the intensification of lipid peroxidation processes and the reduction of antioxidant activity have been marked in blood plasma in patients with the exacerbation of extensive psoriasis. The dependence of some indices of metabolism on the clinical picture and the severity of skin process, age, family history has been revealed. Conclusion. Metabolism disorders in patients with psoriasis are of systemic character. It seems appropriate to carry out a deep study of metabolism indices in patients with psoriasis with the following correction of the revealed disorders

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