Saratov JOURNAL of Medical and Scientific Research

Saratov City Clinical Hospital №7

Cytoprotective effect of cytoflavinum at treatment of thermal injury of various severity level

Year: 2012, volume 8 Issue: №1 Pages: 038-042
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Bozhedomov A.J., Morrison V.V., Shulaeva N.M., Nikitina V.V., Ivanenko I.L.
Organization: Saratov State Medical University, Saratov City Clinical Hospital №7
Summary:

The purpose of research was studying of cytoprotective effect of cytoflavinum at a thermal trauma of different severity level. Materials and methods. 169 patients with thermal burns with a favorable outcome and gravity of a thermal trauma from 30 to 170 points on Franc were under research. 28 patients took standard dosage of cytoflavinum while complex therapy. Results. Patients with thermal trauma more than 60 points on Franc took Cytoflavinumuse and demonstrated decrease in intensity of system inflammatory response syndrome (SIRS), reduction of band neutrophils portion, lowering of erythrocyte number, smaller activation ofthrombocytopoiesis, dicrease of concentration of vascular endothelial growth factor. Positive effect was not revealed in group of patients with thermal trauma less than 60 points who received cytoflavinum. Conclusion. Use of cytoflavinum was the most effective at thermal trauma gravity more than 60 points on Franc

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Diagnostic value of markers of vascular endothe-lial injury in thermal traumas

Year: 2011, volume 7 Issue: №3 Pages: 629-632
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Morrison V. V., Bozhedomov A. Yu., Zakharova N. В., Podgornova A. V.
Organization: Saratov City Clinical Hospital №7, Saratov State Medical University
Summary:

The research goal is to study the composition of biological vascular endothelial injury markers in dynamic development of burn disease. Materials and methods: the investigation included 32 patients with thermal burns. The markers of vascular endothelial growth factor (VEGF), monocyte chemotactic protein-1 (MCP-1) and the number of circulating endothelial cells (CECs) were observed. Results: it was revealed that levels of VEGF, MCP-1 and CECs were significantly increased in patients with thermal traumas. Conclusion: VEGF and MCP-1 were proved to be early and prominent vascular endothelial injury markers in burn disease

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