Saratov JOURNAL of Medical and Scientific Research

Kazan State Medical University

Microbial translocation and systemic inflammatory response in HIV-infection

Year: 2013, volume 9 Issue: №3 Pages: 508-512
Heading: Infectious Diseases Article type: Original article
Authors: Khasanova G.K., Bikkinina О.I., Anokhin V.A.
Organization: Kazan State Medical University
Summary:

The purpose of the research was detection of markers of systemic inflammatory response syndrome together with levels of markers of gram-negative endotoxinemia in HIV-patients for evaluation of role of endotoxin in immune system hyperactivation and progression of disease. Material and methods. Evaluation of levels of endotoxin, sCD14, interleu-kin 1(3, TNF-a and C-reactive protein was done in 232 HIV-positive patients. LAL-test, ELISA and biochemical tests were used. Results. The statistically significant increase of levels of all markers of systemic inflammatory response which were investigated was detected in the group of HIV-positive patients, comparing to group of healthy individuals. Direct correlation of sCD14 level with most of markers of systemic inflammatory response was found. Increased level of sCD14 was associated with more prominent clinical and laboratory signs of immunosupression. Conclusion. These results confirm a role of endotoxin which is a marker of microbial translocation and highly active biological substance in pathogenesis of immune system hyperactivation and progression of HIV-infection.

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Kazan period of life-sustaining activity of professor V.I. Ra-zumovsky — a pioneer of Russian neurosurgery

Year: 2012, volume 8 Issue: №2 Pages: 365-368
Heading: Neurology Article type: Review
Authors: Sozinov A.S., Ismagilov M.F., Danilov V.I., Jakupov E.Z.
Organization: Kazan State Medical University
Summary:

There were presented historical data of life-sustaining activity of professor V. I. Razumovsky — a pioneer of Russian neurosurgery, who began to perform and then was performing systematically neurosurgical operations in the Kazan clinic under the guidance of outstanding neurologists V. M. Bekhterev and L. O. Darkshevich.

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Clinical and economic efficacy of medical equipment at municipal health care institutions in megapolis

Year: 2011, volume 7 Issue: №4 Pages: 779-783
Heading: Health Service Organization Article type: Original article
Authors: Shulaev А.V., Mazitov M.R., Gataullin M.R.
Organization: Kazan State Medical University, Kazan Public Health Service
Summary:

Introduction of health insurance system provided modernization of medical facilities and equipment. High costs on medical equipment especially imported require economic analysis of its use. The aim of the study was to conduct clinical and economic analysis of efficacy of medical equipment use by municipal health care agencies in megapolis. Materials and methods: Annual reports on medical devices and anonymous questionnaires were included into the research. The study revealed the following results: more than 48,65% of medical equipment owned by hospitals exploited during 6-10 years and was retired. Due to insufficient funding only 49,13% of all medical equipment undergoes technical maintenance. Lack of equipment reduces the amount of free medical service. Conclusion: Health care institutions are provided with medical equipment in 30-40%. It results in quality of medical equipment in polyclinics and hospitals where up to 80% of technology is obsolete. Rational use of medical equipment makes possible to provide diagnostic assistance to population in megapolis

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ROLE OF TUMOR SUPRESSOR P53 IN GENESIS OF ANGIOGENIC PHENOTYPE OF A NEOPLASM IN COURSE OF OVARIAN CARCINOMA

Year: 2008, volume 4 Issue: №1 Pages: 29-33
Heading: Macro- and Micromorphology Article type: Original article
Authors: I.I. Antoneeva, S.B. Petrov
Organization: Kazan State Medical University, Ulyanovsk State University
Summary:

The parameters of a vascular bed (vascular volume in % andvasculardencityon 1 mm2 of tumor) were estimated on the operational-bioptic aspirate of the primary tumor of 83 patients with the ovary cancer (ОС). The immunohistochemical method with the use of mice monoclonal antibodies p53, clone DO-7, lgG2b(M7001 DakoCytomation) has been applied for the estimation of the level of p53 expression. Based on the estimated parameters we can conclude that there is no distinctive group of differences among the different clinical stages of the ОС. However, there is a weak positive correlation between the volume and density of vessels and the disease stages. At the same time, the quantity of the atypical epithelial cells of the primary tumor that express p53 is significantly increasing in each subsequent stage. The results of the research show the possible p53 inactivation in the tumor cells and the stimulatory role ofp53in the neoangiogenesis in the course of the tumor progression.

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