Saratov JOURNAL of Medical and Scientific Research

Chekhonatskaya M.L.

Saratov State Medical University, Research Institute for Fundamental and Clinical Urology Nephrology

Possibilities of radiological methods in the diagnosis of bilateral uroepithelial cancer (clinical case)

Year: 2019, volume 15 Issue: №3 Pages: 666-668
Heading: Urology Article type: Case report
Authors: Chekhonatskaya M.L., Rossolovsky A.N., Kryuchkov I.A., Kondratyeva O.A., Bobylev D.A., Klimashin D.F., Kondratyeva D.A., Zuev V.V., Gladkov V.A.
Organization: Saratov State Medical University
Summary:

The article presents data on the development of urothelial cancer and methods of its diagnosis. A clinical case of diagnosis of bilateral uroepithelial cancer in a patient by magnetic resonance imaging is described.

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Magnetic resonance imaging in the diagnosis of bladder cancer (review)

Year: 2019, volume 15 Issue: №3 Pages: 662-666
Heading: Urology Article type: Review
Authors: Bobylev D.A., Chekhonatskaya M.L., Rossolovsky A.N., Ponukalin A.N., Kryuchkov I.A., Kondratieva O.A., Zakharova N.B., Abramova A.P., Popkov V.M.
Organization: Saratov State Medical University
Summary:

The current review represents possibilities of magnetic-resonance imaging in bladder cancer diagnostics. The most important indicator that determines the bladder cancer prognosis and surgical treatment tactics is the muscle wall invasion. Dynamic-contrast-enhanced magnetic resonance imaging and diffusion-weighted magnetic resonance imaging can determine the depth of invasion, although although both are susceptible to over-staging. Magnetic resonance imaging and computed tomography have approximately the same accuracy in determining perivesical invasion as well as in relation to metastatic lymph nodes less than 8 mm in diameter. A promising new technique is the ultra-small paramagnetic iron oxide particles-enhanced magnetic resonance imaging.

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The value of tumor markers in prognos-ing the outcomes of treatment of patients with bladder cancer

Year: 2018, volume 14 Issue: №4 Pages: 661-666
Heading: Urology Article type: Review
Authors: Ponukalin A.N., Zakharova N.B., Skriptsova S.A., Fomkin R.N., Chekhonatskaya M.L.
Organization: Saratov State Medical University n.a. V I. Razumovsky, Scientific Research Institute of Fundamental and Clinical Uronephrology, Saratov State Medical University
Summary:

The review analyzes the recent publications of the results of the use of molecular genetic markers of bladder cancer (RMP) in clinical practice. The prospects of application of a series of molecules determined in tumor tissue, serum, urine in the diagnosis of RMP are presented. One ofthe most promising areas of finding a marker forthe diagnosis and control of treatment of RMP in recent years are the study ofthe proteomic composition of urine.

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Radiation methods for evaluating renal function in children

Year: 2018, volume 14 Issue: №3 Pages: 385-388
Heading: Radiology Article type: Review
Authors: Chekhonatskaya M.L., Averianov А.Р., Uts I.A., Velikanova M.G., Bobylev D.A., Chekhonatsky I.A.
Organization: Clinical hospital n.a. S. R. Mirotvortsev SSMU, Russian Medical Academy of Postgraduate Education, Moscow, Saratov State Medical University
Summary:

 An accurate assessment of renal function is critical for adequate dosing of medications. The most informative marker reflecting the functional state of the kidneys is glomerular filtration rate (GFR). Determination of inulin clearance is the most accurate way to assess GFR in children and adults. In this case, the method is invasive, cumbersome, younger children require the installation of a urinary catheter. Techniques for radioisotope estimation of GFR can solve this problem, but all widely used radioisotopes have the ability to bind slightly to plasma proteins, which leads to an underestimation of real values.

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A comprehensive approach to the diagnosis and treatment of straghorn nephrolithiasis

Year: 2018, volume 14 Issue: №1 Pages: 81-86
Heading: Urology Article type: Review
Authors: Chekhonatskaya M.L., Rossolovsky A.N., Kryuchkov I.A., Bobylev D.A.
Organization: Saratov State Medical University
Summary:

A review of the literature is devoted to the most topical diagnostic questions and treatment of patients with urolithia-sis. The role and the latest advances and benefits of minimally invasive surgery were described. Particular attention was paid to the problems of residual calculi and the condition of the renal parenchyma in the perioperative period. The theme of choice of conducting such patients tactics was considered. The actual diagnostic methods and a differentiated approach to the algorithm choice of the examination and treatment of patients with staghorn nephrolithiasis were considered. The review provided a scientometric analysis of research information (documents reference), contained the analytical array of scientific publications. Electronic information resources of scientific electronic library bibliographic databases: eLibrary, PubMed, Clinical Key, Science Direct — were used.

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Correlation between size and density indices of concrements in patients with nephrolithiasis and effective method of treatment by distance shock-wave lithotripsy

Year: 2017, volume 13 Issue: №1 Pages: 77-81
Heading: Urology Article type: Original article
Authors: Chekhonatskaya M.L., Rossolovsky A.N., Bobylev D.A.
Organization: Saratov State Medical University
Summary:

The aim of the article: evaluation of the results of treatment of patients with nephrolithiasis by distance shock-wave lithotripsy on the basis of the data on kidneys received from multispiral computed tomography. Material and Methods. The study involved 46 patients who were hospitalized in the clinic of urology with diagnosed urolithiasis with the pres- ence of a renal calculus from 10 to 17 mm in size. A complex of laboratory analyses including multispiral computed tomography was used. The concrement elimination was carried out by distance shock-wave lithotripsy Results. Correlation analysis and ROC-analysis did not show the efficacy of distance shock-wave lithotripsy comparing scanning procedures and distance shock-wave lithotripsy. Conclusion. The size and average density of a concrement according to multispiral computed tomography should not be served as a basis for prognosis of effective fragmentation of concre-ments by distance shock-wave lithotripsy in patients with urolithiasis caused by stones of 10-17 mm in size.

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Ultrasonic Dopplerometry in diagnosis of cervical injury in birth process

Year: 2017, volume 13 Issue: №1 Pages: 047-050
Heading: Radiology Article type: Original article
Authors: Chekhonatskaya M.L., Bakhmach V.O., Zabozlaev F.G., Chekhonatsky V.A.
Organization: Russian Medical Academy of Post-graduate Education, Saratov State Medical University
Summary:

The goal was to carry out the comparative analysis of ultrasonic Doppler indices and data of morphometric methods of uterine cervix examination of women with prenatal moving of amniotic fluid depending on presence or absence of uterine cervix trauma in labor. Material and methods. 148 pregnant women with prenatal moving of amniotic fluid were examined. The main group included 64 pregnant women with uterine cervix ruptures; the comparison group consisted of 84 patients without any labor trauma. Ultrasonic and morphological examinations of uterine cervix were carried out. Results. Cavernous transformation of venous cervical bloodstream closely correlated (r = 0,67, p <0.001) with the index of vascularization degree and labortrauma degree. Conclusion. The revealed echomorphological relationship in uterine cervix of pregnant women with various labor outcomes allowed using these data to predict uterine cervix rupture in labor process.

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Assessment of hemodynamic parameters of uterus during physiological pregnancy

Year: 2015, volume 11 Issue: №2 Pages: 151-156
Heading: Radiology Article type: Original article
Authors: Chekhonatskaya M.L., Petrosyan N.O.
Organization: Saratov State Medical University
Summary:

The aim of the article is to analysis of the hemodynamic parameters of the uterus and cervix during the second and third trimesters of pregnancy. Material and methods. It was conducted dynamic ultrasound in 240 women with physiological course for singleton pregnancies in the period from 12 weeks of gestation until term labor. Results. For the second trimester of pregnancy redistribution of total uterine blood flow in the direction of increasing blood flow in more of the body than the cervix has been considered to be typical. From the third trimester of pregnancy until term labor a significant increase of blood supply to the cervix has been found; there has been a tendency to increase the capacity of the vascular channel and the reduction in peripheral resistance vessels of cervix. Conclusions. Early detection of disorders of uterine and cervical hemodynamics allows to predict the occurrence of various pathological conditions.

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Ultrasound Diagnostics of Premature Birth

Year: 2014, volume 10 Issue: №1 Pages: 74-79
Heading: Obstetrics and Gynecology Article type: Review
Authors: Chekhonatskaya M.L., Vasilevich L.K., Petrosyan N.O., Kolesnikova E.A.
Organization: Clinical hospital n.a. S. R. Mirotvortsev SSMU, Saratov Clinical Hospital № 8, Saratov State Medical University
Summary:

The purpose of the article is to analyze the data of native and foreign literature and to consider the modern aspects of ultrasound diagnostics of premature birth, and new additional criteria for early diagnostics and prediction of preterm delivery. Hemodynamic characteristics in the second and third trimesters of the pregnancy have been covered.

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Ultrasound diagnostics of postpartum endometritis

Year: 2014, volume 10 Issue: №1 Pages: 65-69
Heading: Obstetrics and Gynecology Article type: Review
Authors: Bratchikova О.А., Chekhonatskaya M.L., Yannaeva N.E.
Organization: Saratov State Medical University
Summary:

The purpose of the article is to present data on diagnostics of postpartum infectious diseases in women in childbirth. The aim of the conducted survey is to study modern ultrasound diagnostic methods of the given pathology.

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