Saratov JOURNAL of Medical and Scientific Research

thyroid hormones

Functional state of kidneys in patients with clinical manifestations of hypothyroidism

Year: 2012, volume 8 Issue: №2 Pages: 333-338
Heading: Endocrinology Article type: Original article
Authors: Orlova М.М., Rodionova T.I.
Organization: Saratov State Medical University
Summary:

The research goal is to study the function of kidneys and serum concentration of immunoregulatory cytokines (IL-1ГА, IL-6, IL-8, IL-10) in conditions of thyroid hormone deficit. Methods: The character and severity of renal dysfunction were investigated in patients with primary hypothyroidism. The clinical examination included study of serum concentration of creatinine, urea level, potassium and natrium in blood serum, blood and urine analyses, total cholesterol, high and low density lipoproteins, daily microalbuminuria, the performing of Zimnitsky test, urinary excretion of chemokines MCP-1, RANTES, rate calculation of glomerular filtration, thyroid hormone state. Results: The renal function in clinical hypothyroidism without concomitant kidney disturbances was characterized by normal parameters of the concentra-tional kidney function, reduction of glomerular filtration rate, increased of serum creatinine, urea excretion level of chemokine MCP-1 and level of cytokines IL-6, IL-8 in patients with autoimmune hypothyroidism were revealed. Conclusion: It was revealed that autoimmune hypothyroidism effected balance disturbance of cytokine-producing activity of Th1 and Th2 type therefore developing autoimmune state and disease progression

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INFLUENCE OF THYROID HORMONES ON MYOCARDIAL METABOLIC PROCESSES

Year: 2009, volume 5 Issue: №1 Pages: 123-127
Heading: Reviews Article type: Review
Authors: T.I. Rodionova, V.V. Samitin
Organization: Saratov State Medical University
Summary:

The authors present contemporary data of mechanisms of thyroid hormones action on myocardial metabolism. Special attention was paid to non-genomic effects of thyroid hormones; the authors also discuss alterations in metabolic pathways and structural changes of myocardium which are developing in hypothyroid condition.

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