Saratov JOURNAL of Medical and Scientific Research

Rodionova T.I.

Saratov State Medical University, Department of Endocrinology, Professor, Doctor of Medical Science

Assessment of efficiency of application of various analogues of insulin in treatment of diabetes type 2

Year: 2014, volume 10 Issue: №3 Pages: 461-464
Heading: Endocrinology Article type: Original article
Authors: Rodionova T.l., Orlova M.M.
Organization: Saratov State Medical University
Summary:

Purpose: to estimate efficiency of treatment of analogues of insulin Glargin and insulin Detemir in patients with diabetes type 2. Material and methods. 147 patients with diabetes type 2 which have been initially receiving combined therapy by oral antihyperglycemic agent and NPH-insulin have been under the study. Level of glycated hemoglobin has been defined in 3 and 6 months for the general assessment of control of aglycemia. Results. According to the study the use of insulin analogues (Detemir, Glargin) versus NPH insulin for 6 months allowed to reach individual target values of glycemia in 70% of patients with diabetes type 2 with a low risk of hypoglycemia. Conclusion. The use in clinical practice of modern insulin analogues and simple algorithm for dose titration, allows simulating as closely as possible the physiological insulin secretion, helping to achieve compensation of carbohydrate metabolism in larger numbers of patients in comparison with NPH insulin.

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Laser thermal therapy is increasingly being used in clinical practice for cancer treatment. Its major limitation is associated with low spatial selectivity. This restriction may be excluded by the use of plasmon-resonant gold nanoparticles as photothermal

Year: 2013, volume 9 Issue: №4 Pages: 700-706
Heading: Oncology Article type: Review
Authors: Chumakov D.S., Basko M.V., Dikht N.I., Bucharskaya A.B., Rodionova Т.I., Terentyuk G.S.
Organization: Saratov State Medical University, Saratov state university
Summary:

Laser thermal therapy is increasingly being used in clinical practice for cancer treatment. Its major limitation is associated with low spatial selectivity. This restriction may be excluded by the use of plasmon-resonant gold nanoparticles as photothermal sensitizers. Tunable synthesis, unique optical properties and low toxicity make gold nanostructures promising as a therapeutic agent for cancer treatment. The research work has presented the experimental data that concern the use of plasmon photothermal therapy for the treatment of transplanted and induced tumors of laboratory animals. Taking into consideration the research results it is determined that the transition of this therapeutic technology into the clinical practice can be predicted.

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RIsk factors of diabetic neuropathy in patients with diabetes mellitus type 1

Year: 2012, volume 8 Issue: №2 Pages: 442-445
Heading: Neurology Article type: Original article
Authors: Kalashnicov A.I., Chobitko V.G., Maksimova O.V., Rodionova T.I.
Organization: Saratov State Medical University
Summary:

Purpose: identifcation of risk factors for peripheral neuropathy in diabetes mellitus type 1. The material. Examined 46 patients 1 diabetes with distal полинейропатией. Studied clinical parameters: gender, age, hereditary predisposition, duration of the disease, the presence of arterial hypertension and diabetes of microangiopathy; the laboratory parameters: the level of glycosylated hemoglobin and cholesterol in blood serum. Results. Risk factors of formation of diabetic neuropathy are duration of diabetes, chronic hyperglycemia, the presence of microangiopathy diabetic lower extremity and arterial hypertension.

Keywords: -
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Functional state of kidneys in patients with clinical manifestations of hypothyroidism

Year: 2012, volume 8 Issue: №2 Pages: 333-338
Heading: Endocrinology Article type: Original article
Authors: Orlova М.М., Rodionova T.I.
Organization: Saratov State Medical University
Summary:

The research goal is to study the function of kidneys and serum concentration of immunoregulatory cytokines (IL-1ГА, IL-6, IL-8, IL-10) in conditions of thyroid hormone deficit. Methods: The character and severity of renal dysfunction were investigated in patients with primary hypothyroidism. The clinical examination included study of serum concentration of creatinine, urea level, potassium and natrium in blood serum, blood and urine analyses, total cholesterol, high and low density lipoproteins, daily microalbuminuria, the performing of Zimnitsky test, urinary excretion of chemokines MCP-1, RANTES, rate calculation of glomerular filtration, thyroid hormone state. Results: The renal function in clinical hypothyroidism without concomitant kidney disturbances was characterized by normal parameters of the concentra-tional kidney function, reduction of glomerular filtration rate, increased of serum creatinine, urea excretion level of chemokine MCP-1 and level of cytokines IL-6, IL-8 in patients with autoimmune hypothyroidism were revealed. Conclusion: It was revealed that autoimmune hypothyroidism effected balance disturbance of cytokine-producing activity of Th1 and Th2 type therefore developing autoimmune state and disease progression

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Stressogenic aspects of diffuse toxic goiter relapse with signs of thyrotoxic myocar-dial dystrophy

Year: 2011, volume 7 Issue: №1 Pages: 174-175
Heading: Endocrinology Article type: Original article
Authors: Rodionova T.I., Onyushkina N.Yu.
Organization: Saratov State Medical University
Summary:

Probability of relapse development of diffuse toxic goiter during the nearest two years after treatment is determined by its results and stressogenic capacity level, which is defined by Holmes and Rage method. As long as satisfactory treatment results and level of stressogenic capacity are above 300 points, the risk of diffuse toxic goiter relapse run to 68,5%

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Insulinotherapy as a medico-social phenomenon and quality of life of patients with type 1 diabetes mellitus

Year: 2010, volume 6 Issue: №4 Pages: 863-866
Heading: Endocrinology Article type: Review
Authors: Kargina L.V., Dorogoykin D.L., Rodionova T.I., Utts I.A.
Organization: Saratov State Medical University
Summary:

The article examines the factors influencing availability of insulinotherapy, modern insulin types, methods of insulin administration, and insulin pump as one of its number. The authors explicate some challenges connected with availability of insulin therapy for patients with type 1 diabetes mellitus belonging to various social groups

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Significance of bioregulation and indications to its usage in complex treatment of thyrotoxic myocardiodystrophy

Year: 2010, volume 6 Issue: №2 Pages: 338-341
Heading: Internal Diseases Article type: Original article
Authors: T.I. Rodionova, .S.N. Nikolenko, N.Yu. Onyushkina
Organization: Saratov State Medical University, Saratov City Polyclinic № 20
Summary:

Significance of biological feedback (BFB) therapy in complex treatment of patients with thyrotoxic myocardiodystrophy was analyzed. Evaluation of bioregulation procedures was conducted in 36 patients with diffusive toxic goiter (DTG) and signs of thyrotoxic myocardiodystrophy on the background of drug therapy. Control group consisted of 24 patients with DTG, which took only drug therapy. It was revealed, that combination of drug therapy of DTG with BFB procedures provided significant influence on state of vegetative nervous system, and it also led to quick decrease of clinical symptoms of thyrotoxic myocardiodystrophy, in contrast to isolated drug therapy

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THE SIGNIFICANCE OF SUBCLINICAL HYPOTHYROIDISM AND ITS SUBSTITUTIONAL THERAPY INFLUENCE ON DEVELOPMENT OF CARDIOVASCULAR PATHOLOGY

Year: 2008, volume 4 Issue: №4 Pages: 127-131
Heading: Reviews Article type: Review
Authors: V.V. Samitin, T.I. Rodionova
Organization: Saratov State Medical University
Summary:

This review presents the modern data concerning influence ofsubclinicalhypothyroidism on morphology and functional state of myocardium and arterial vessels, traditional and "new" cardiovascular risk factors. The riskof clinically significant complications (cardiovascular diseases, disorders ofhemostasis and changes in lipidexchange) connected with subclinical hypothyroidism is under research. The data on the effects of subclinical hypothyroidism substitutional therapy are highlighted in the work

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INFLUENCE OF THYROID HORMONES ON MYOCARDIAL METABOLIC PROCESSES

Year: 2009, volume 5 Issue: №1 Pages: 123-127
Heading: Reviews Article type: Review
Authors: T.I. Rodionova, V.V. Samitin
Organization: Saratov State Medical University
Summary:

The authors present contemporary data of mechanisms of thyroid hormones action on myocardial metabolism. Special attention was paid to non-genomic effects of thyroid hormones; the authors also discuss alterations in metabolic pathways and structural changes of myocardium which are developing in hypothyroid condition.

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