Saratov JOURNAL of Medical and Scientific Research

Terentyuk G.S.

The First Veterinary Clinic, Professor, Doctor of Bological Science

The assessment of molecular markers of cell interaction and lipid peroxidation in rats with alloxan diabetes and trans- planted liver cancer after intravenous injection of gold nanorods

Year: 2015, volume 11 Issue: №2 Pages: 107-112
Heading: Biochemistry Article type: Original article
Authors: Bucharskaya А.В., Dikht N.I., Afanasyeva G.A., Terentyuk G.S., Zakharova N.B., Maslyakova G.N., Khlebtsov B.N., Khlebtsov N.G.
Organization: Institute of Biochemistry and Physiology of Plants and Microorganisms of Russian Academy of Sciences, Saratov State Medical University
Summary:

Цель: оценить воздействие однократного внутривенного введения покрытых полиэтиленгликолем золотых наностержней на молекулярные маркеры межклеточного взаимодействия и показатели перекисного окисления в сыворотке крови четырех групп крыс: интактных, с аллоксановым диабетом, с перевитым раком печени; с перевитым раком печени на фоне аллоксанового диабета. Материалы и методы. Активность перекисного окисления липидов оценивалась по показателям гидроперекисей липидов, малонового диальдегида и молекул средней массы с использованием общепринятых спектрофотометрических методов, исследования молекулярных маркеров — фактора некроза опухоли TNF-a, инсулиноподобного фактора роста IGF-1, васкулоэн-дотелиального фактора роста VEGF-C проводились в сыворотке крови методом иммуноферментного анализа. Результаты. Выявлено, что при однократном внутривенном введении золотых наностержней не происходит значительного изменения количества маркеров межклеточного взаимодействия и показателей перекисного окисления липидов. в периферической крови. Заключение. Полученные результаты позволяют рекомендовать использование покрытых полиэтиленгликолем золотых наностержней в экспериментальной онкологии.

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Laser thermal therapy is increasingly being used in clinical practice for cancer treatment. Its major limitation is associated with low spatial selectivity. This restriction may be excluded by the use of plasmon-resonant gold nanoparticles as photothermal

Year: 2013, volume 9 Issue: №4 Pages: 700-706
Heading: Oncology Article type: Review
Authors: Chumakov D.S., Basko M.V., Dikht N.I., Bucharskaya A.B., Rodionova Т.I., Terentyuk G.S.
Organization: Saratov State Medical University, Saratov state university
Summary:

Laser thermal therapy is increasingly being used in clinical practice for cancer treatment. Its major limitation is associated with low spatial selectivity. This restriction may be excluded by the use of plasmon-resonant gold nanoparticles as photothermal sensitizers. Tunable synthesis, unique optical properties and low toxicity make gold nanostructures promising as a therapeutic agent for cancer treatment. The research work has presented the experimental data that concern the use of plasmon photothermal therapy for the treatment of transplanted and induced tumors of laboratory animals. Taking into consideration the research results it is determined that the transition of this therapeutic technology into the clinical practice can be predicted.

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Surface modification of orthodontic implants by nanocomposite coatings based on chitosan and metals

Year: 2013, volume 9 Issue: №3 Pages: 472-477
Heading: Stomatology Article type: Original article
Authors: Suetenkov D.Ye., Gorin D.A., Portnov S.A., Karagaychev A.L., Terentyuk G.S., Zakharevich A.M., Khlebtsov B.N., Firsova I.V.
Organization: Saratov State Medical University, Saratov state university, Институт биохимии и физиологии растений и микроорганизмов РАН
Summary:

Purpose: to study the properties of nanostructured coatings in orthodontic implants. Material and methods. Low and average molecular mass chitosan, 3-amynopropil-3-methoxysylan and suspensions of 5 nm and 10 nm gold nano-spheres stabilized with natrium citrate were used for nanocomposed surfaces. 2mg/ml polyethylenamin water solution was used for making the underlayer before putting polyion coverage using «POLYION-1M». The polyion covering dynamics was studied by polyquartz weighing method. Morphology of created layers was studied with atomic microscopy, elements were studied by secondary ion mass-spectrometry. Results. The best transmission among structures of chito-san/metals was showed by low molecular mass of chitosan and 8-1 Onm nanoparticles of metals. Analysis of roughness of surface shows that nanoparticles of gold make the most solid surface on 3-amynopropil-3-methoxysylan underlayer. Conclusion. The development of biocomparative materials in maxillofacial surgery is considered to be effective method of decreasing the risk of post-operative inflammatory complications by local antibacterial effect.

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Comparative characteristics of mammary glands cancer in humans and animals

Year: 2012, volume 8 Issue: №3 Pages: 706-711
Heading: Physiology and Pathophysiology Article type: Review
Authors: Vorobyova О.V., Terentyuk G.S., Bucharskaya A.B.
Organization: Saratov State Medical University, Chuvash State University n.a. I.N. Ulyanov
Summary:

This review is devoted to a comparative analysis of receptor status, immunity, angiogenesis, metastatic mammal glands cancer expression profiling in humans and animals. Angiogenesis has been assessed by quantitative and immunohistochemical characteristics by means of evaluation of microvascular density (MVD) using Claudin-5 (CLDN-5) as a marker of vascular endothelium in tumors of mammary glands in dogs.

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Effects Used of Orthodontic Micro-implants with Modified Coat: an Animal Study

Year: 2011, volume 7 Issue: №1 Pages: 262-266
Heading: Stomatology Article type: Original article
Authors: Suetenkov D.Ye., Terentyuk G.S., Karagaychev A.L., Lyasnikova A.V.
Organization: The First Veterinary Clinic, Saratov National Research University n.a. N. G. Chernyshevsky, Saratov State Technical University, Saratov State Medical University
Summary:

Assess the overall effects and the dynamics of circulating immune complexes using orthodontic miniscrew with nanostructured coatings containing silver and gold. The diagnostic significance of circulating immune complexes in inflammatory complications. Proved the harmlessness of such structures in animals

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2011_01_Прил_262-266.pdf681.22 KB