Saratov JOURNAL of Medical and Scientific Research

Saratov State Medical University

www.sgmu.ru

Radiation methods for evaluating renal function in children

Year: 2018, volume 14 Issue: №3 Pages: 385-388
Heading: Radiology Article type: Review
Authors: Chekhonatskaya M.L., Averianov А.Р., Uts I.A., Velikanova M.G., Bobylev D.A., Chekhonatsky I.A.
Organization: Clinical hospital n.a. S. R. Mirotvortsev SSMU, Russian Medical Academy of Postgraduate Education, Moscow, Saratov State Medical University
Summary:

 An accurate assessment of renal function is critical for adequate dosing of medications. The most informative marker reflecting the functional state of the kidneys is glomerular filtration rate (GFR). Determination of inulin clearance is the most accurate way to assess GFR in children and adults. In this case, the method is invasive, cumbersome, younger children require the installation of a urinary catheter. Techniques for radioisotope estimation of GFR can solve this problem, but all widely used radioisotopes have the ability to bind slightly to plasma proteins, which leads to an underestimation of real values.

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The study on the refraction of morphofunctional changes in kidneys of white male rats with experimental light desynchronosis

Year: 2018, volume 14 Issue: №3 Pages: 363-367
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Zlobina O.V., Ivanov A.N., Antonova V.M., Milashevskaya T.V., Bugaeva I.O.
Organization: Saratov State Medical University
Summary:

The goal is to study the morphofunctional changes in the kidneys under the influence of light desynchronosis, an analysis of the degree of reversibility of these changes. Material and Methods. The study was carried out in two stages on 72 white male rats. In the first series of experiments, animals underwent round-the-clock light exposure for 10 and 21 days. In the second series after round-the-clock exposure to light for 10 and 21 days, the beings were exposed to natural light for 21 days. The animals of the control group were kept in a natural light regime. Morphological and morphometric analysis of histological sections of kidneys stained with hematoxylin and eosin was performed. Results. It was found that on the 10th day of the experiment, cellular infiltration of the cortex occurs, and the edema of the interstitial tissue develops. These changes progress to the 21st day of the experiment and are combined with a significant decrease in the area of the glomerular capillary network and expansion of the lumen of the capsule of the glomerulus of cortical nephrons. When assessing the long-term consequences after 10-day illumination, the diameter of the renal corpus is reduced along the long and short axis. The changes registered on the 21st day do not reach the control values, which indicate that they are irreversible. Conclusion. The revealed structural and functional changes in the kidney indicate a negative effect of light desynchronosis: 10-day lighting leads to a breakdown of compensatory possibilities and the development of distant morphological changes; long-term light exposure (within 21 days) leads to the development of pronounced irreversible structural disorders.

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Comparative "portrait" of a hospital patient in Saratov Regional Hospital for Veterans of Wars in 2005 and 2017

Year: 2018, volume 14 Issue: №2 Pages: 349-351
Heading: Gerontology and geriatrics Article type: Original article
Authors: Tyultyaeva L.A., Lipatova Т.Е., Bulychev S.V., Kovalev Е.Р., Alipova L.N.
Organization: Saratov Regional Hospital for Veterans of Wars, Saratov State Medical University
Summary:

Objective: to analyze the number of patients, patients' opinions about the work of the medical institution in 2005 and 2017. Material and Methods. The data of the survey of patients of the Saratov Regional Hospital for Veterans of Wars in 2005 and 2017 are analyzed. Results. From 2005 to 2017, there was a change in the sex (decrease in the proportion of hospitalized men) and age (increase in the proportion of hospitalized patients over the age of 60 years) composition of hospital patients. The increase of the general educational level of patients, the increase of the share of patients who are in this hospital not for the first time is revealed. The share of patients satisfied with medical work and work of the power supply unit in this hospital has increased. The preference of paternalistic style of interaction between a doctor and a patient, typical for both patients in 2005 and patients in 2017, was revealed. Conclusion. Despite the increase in the educational level of patients and the increase in satisfaction with the work of the hospital, patients of this medical institution prefer a paternalistic style of interaction with the doctor.

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Erythrocyte system in elderly: ageing aspects

Year: 2018, volume 14 Issue: №2 Pages: 341-345
Heading: Gerontology and geriatrics Article type: Original article
Authors: Malinova L.I., Denisova Т.Р., Lipatova Т.Е., Khvostikova D.E., Yegorova A.V.
Organization: Saratov State Medical University
Summary:

The purpose of the study was an assessment of erythrocyte system age-dependent characteristics in elderly population dwelling in the same territory during the time period equal to the average life span in the region. Material and Methods. We perform the compare of hematological parameters of 800 patients with hypertension and coronary heart disease hospitalized during 25-years period. Results. In senile patients, red blood cells and hemoglobin levels signifi- cantly decrease, but platelet characteristics remain intact. Revealed differenced are similar during all 25-year period of observation. Conclusion. Over the past 25 years, the trend of age-related decline in the number of red blood cells and hemoglobin has been preserved. The average hemoglobin content in erythrocyte (MCH) during the aging process tends to decrease, which has become statistically significant in recent years. The principal difference of the obtained data from the results of obtained 25 years ago is the absence of an age-related increase in the volume of erythrocytes and a higher level of the average concentration of hemoglobin in the erythrocyte.

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The structure of the "acute abdomen" in a period of social stress in a large industrial center

Year: 2018, volume 14 Issue: №2 Pages: 338-341
Heading: Gerontology and geriatrics Article type: Original article
Authors: Lipatova Т.Е., Tyultyaeva L.A., Semenov S.V., Kovalev Е.Р.
Organization: Saratov Regional Hospital for Veterans of Wars, Saratov State Medical University
Summary:

Purpose: to analyze the prevalence of acute abdominal pathology in the period of social stress. Material and Methods. The data of official statistical reports of the Saratov city health Committee and the logs of patients admitted and discharged / deceased in the surgical clinics of the city were studied. The prevalence of acute appendicitis, acute cholecystitis, acute pancreatitis, acute intestinal obstruction, gastrointestinal bleeding, perforation of ulcers during 1990-2006 among the population of different age groups (young, mature, elderly /old) was investigated. The significance of differences between the groups was assessed using white's T-test. Results. A decrease in the prevalence of acute appendicitis, an increase in the prevalence of acute pancreatitis and gastrointestinal bleeding. Differences in the prevalence of acute abdominal diseases in patients of different age groups were found: an increase in the prevalence of acute pancreatitis mainly in the young population. There is a tendency to gradual Erasure of sexual differences in acute cholecystitis and acute pancreatitis in this period. Conclusion. The analyzed time interval was characterized by changes in the structure of the "acute abdomen", which may be associated with social changes in society during this period.

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Clinical diagnosis in terms of insurance medicine

Year: 2018, volume 14 Issue: №2 Pages: 327-330
Heading: Gerontology and geriatrics Article type: Author's opinion
Authors: Denisova Т.Р., Lipatova Т.Е., Malinova L.I., Tyultyaeva L.A., Kovalev Е.Р., Alipova L.N., Vakhlyueva O.G.
Organization: Saratov Regional Hospital for Veterans of Wars, Saratov State Medical University
Summary:

Medical institutions in the conditions of insurance medicine are faced with not always justified interference of insurance companies in the structure of diagnosis and diagnostic process, whose violate the essence of the concepts of clinical classifications and statistical coding of diagnoses provided by ICD-10. Such a situation ultimately harms the patient and society, makes it difficult both to monitorthe adequacy of the ongoing treatment activities, and to protect the patient's rights to receive qualified medical care and doctor's rights.

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Interaction of atherosclerosis and ageing: is there any discussion questionable?

Year: 2018, volume 14 Issue: №2 Pages: 322-327
Heading: Gerontology and geriatrics Article type: Author's opinion
Authors: Denisova Т.Р., Lipatova Т.Е., Alipova L.N., Yegorova A.V.
Organization: Saratov Regional Hospital for Veterans of Wars, Saratov State Medical University
Summary:

Age-related diseases and their link to involutionary processes in human organism remain as one of the burning problems in internal medicine. The article focuses on the discussable questions of the most common mechanisms of atherogenesis and ageing, their similarity and difference. Both processes mutually burdens each other, bringing the "fading" of the organism closer.

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Professor Valeriy Vladimirovich Shchukovsky (to the 70th anniversary)

Year: 2018, volume 14 Issue: №2 Pages: 309-311
Heading: Scientific schools and memorable dates Article type: Short message
Authors: Ulyanov V.Yu., Grishin S.E., Puchinyan D.M., Fedonnikov A.S., Shchukovsky N.V., Norkin I.A.
Organization: Saratov Socio-Economic Institute of Plekhanov Russian University of Economics, Saratov State Medical University
Summary:

The article illustrates the life of Professor Valeriy Vladimirovich Shchukovsky and his scientific contribution into the development of separate branches of emergency medicine, namely intensive care of patients with embolism and acute thromboses of large vessels, severe thermal traumas, endotoxemia and multiorgan dysfunction syndrome, traumatic disease of spinal cord and its visceral complications in acute and early periods, reperfusion visceral injuries following its transplantation and patients with coagulopathic hemorrhage.

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Professor V.A. Surat and his contribution to the development of national pediatrics (to the 125th birth anniversary)

Year: 2018, volume 14 Issue: №2 Pages: 306-308
Heading: Scientific schools and memorable dates Article type: Short message
Authors: Zavyalov A.l., Denishev R.R.
Organization: Saratov State Medical University
Summary:

The article is devoted to medical, scientific, pedagogical and public activities of V.A. Surat who was a professor and a head of pediatric departments in Saratov, Alma-Ata and Stalingrad Medical Universities.

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Variability of linear parameters of frontal sinuses in adults

Year: 2018, volume 14 Issue: №2 Pages: 302-305
Heading: Human anatomy Article type: Original article
Authors: Mareev O.V., Aleshkina O.Yu., Mareev G.O., Kuchmin V.N., Afonina O.I., Kapustina N.Yu.
Organization: Saratov State Medical University
Summary:

Objective: to identify the variability of frontal sinuses size patterns divided by sex and age in adults. Material and Methods. 83 X-ray computer tomograms of the head of adults without any signs of paranasal sinuses pathology and without traces of surgery on the external structures and internal nose in the history were studied. Results. It has been found the best pneumatized frontal bones in males; the rapid growth of the frontal sinuses occurs more in men in the 1st age group, whereas in women, the formation of the frontal sinus is smoother and more uniform during the whole life. Conclusion. Men have depth prevailing characteristics of frontal sinuses in the 1st age group and the width on the left side in the 2nd age group differing significantly in comparison to women group; height of the sinus in men decreases with age, whereas in women it does not change its value significantly; bilateral values for the parameters of the frontal sinus do not have reliable sex and age differences.

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