Saratov JOURNAL of Medical and Scientific Research

Kunitsyna M.A.

Saratov State Medical University n.a. V.I. Razumovsky, department of hospital therapy assistant professor, candidate of medical science

The treatment of gastroesophageal reflux disease in menopausal women suffering from diabetes mellitus type II

Year: 2016, volume 12 Issue: №4 Pages: 556-560
Heading: Internal Diseases Article type: Original article
Authors: Semikina Т.М., Kunitsyna M.A., Kashkina E.l.
Organization: Saratov State Medical University
Summary:

Purpose: to develop criteria for the selection of optimal tactics of supporting treatment of nonerosive gastroesophageal reflux disease with proton pump inhibitors in menopausal women suffering from diabetes mellitus type II. Material and Methods. 186 patients aged 45-59 who suffer from gastroesophageal reflux disease have been followed up, 46 of which suffer from diabetes mellitus type II as well. The climacteric syndrome's morbidity has been assessed in accordance with the modified menopause index; the level of glycated hemoglobin has been measured by the Abbott analyzer produced in the USA. Results. It is established that irrespective of the supporting treatment, the gastroesophageal reflux disease remittance was shorter in direct proportion with increase of the HbA1c level and the value of the modified menopause index in menopausal women suffering from diabetes mellitus type II. Conclusion. When the climacteric syndrome was mild or moderate, taking 20 mg Omeprazole once a day and "on demand" has comparable results, therefore this group of women prefer the "on demand" regimen as it lowers the risk of osteoporosis progression and further bone fracture. Taking 20 mg Omeprazole once a day, every other day, and "on demand" allows the disease remittance to prolong for a year and longer in less than 30% of women suffering from severe climacteric syndrome and having HbA1c>9.0%; however, this number may grow up to 70% of women in case they follow medical advice and reduce their carbohydrate input to 11 carbohydrate units and less.

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Pancreatogenic diabetes mellitus: actual problems of pathogenesis and treatment

Year: 2012, volume 8 Issue: №3 Pages: 862-867
Heading: Endocrinology Article type: Review
Authors: Rebrov А.P., Kunitsyna М.А., Kashkina E.I., Arkhangelskaya Е.Е.
Organization: Saratov State Medical University
Summary:

We have presented the review of literature devoted to the problem of pancreatogenic diabetes mellitus. We have found up that prevalence of pancreatogenic diabetes mellitus needs to be adjusted. In analyzed literature the influence of localization of structural changes of pancreatic tissue on risk of diabetes mellitus development is studied insufficiently. In the result of our literature analysis we have detected that treatment of pancreatogenic diabetes mellitus up to date is not unified and is mostly descriptive, what indicates on necessity of further investigations in order to optimize and increase the efficacy of its treatment.

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Comparative assessment of efficacy of different methods of treatment of pancreatogenic diabetes mellitus in alcoholic and biliary forms of chronic pancreatitis

Year: 2012, volume 8 Issue: №3 Pages: 859-862
Heading: Endocrinology Article type: Original article
Authors: Kunitsyna М.А., Kashkina E.I.
Organization: Saratov State Medical University
Summary:

Aim: the study was devoted to the analysis of efficacy of different methods of treatment of pancreatogenic diabetes mellitus (DM) in alcoholic and biliary forms of chronic pancreatitis (CP). Material and methods. We have observed 86 patients with CP and first diagnosed DM. The assessment of carbohydrate metabolism compensation via HbA1 с level was done using analyzer IMX «Abbot» (USA). Results. At the 1st step of DM treatment we recommended the lifestyle modification and usage of creon 30-60.000 units daily. At the 2d step of treatment if necessary we added glyclazide. Conclusion. We have detected that irrespective of duration of alcoholic form of CP in case of subsequent DM development the lifestyle modification together with replacement ferment therapy in 90% of cases were non-effective. In the result of the research it was established, in case of 3 and more relapses per year in alcoholic form of CPthe probability of achievement of target HbA1 с level in complex with lifestyle changes and replacement ferment therapy was twice low, in connection with that fact the indication of oral anti-diabetic agents became necessary.

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Features of clinical course and quality of life in patients with chronic pancreatitis and diabetes mellitus

Year: 2011, volume 7 Issue: №1 Pages: 087-091
Heading: Internal Diseases Article type: Original article
Authors: Kunitsyna М.А., Kashkina E.I.
Organization: Saratov State Medical University
Summary:

Clinical and life quality features of 183 patients with chronic pancreatitis and diabetes mellitus were studied. We have found that the incidence of exacerbations increased by 36,7% after the appearance of diabetes mellitus, the number of days of loss of ability to work increased by 27,8%, the quality of life decreased

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