Saratov JOURNAL of Medical and Scientific Research

Endocrinology

Erythropoietin in patients with type 1 diabetes (review)

Year: 2012, volume 8 Issue: №1 Pages: 159-163
Heading: Endocrinology Article type: Review
Authors: Khantakova Е.А., Khamnueva L.Yu.
Organization: Irkutsk State Medical University
Summary:

The article analyzes the literature on the issue of regulation of erythropoietin in patients with type 1 diabetes. The connection between the secretion of erythropoietin disturbance with the development and progression of diabetes complications has been observed. Various pleiotropic effects of erythropoietin have been considered

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Postoperative recurrent nontoxic nodular (multinodular) goiter

Year: 2011, volume 7 Issue: №4 Pages: 975-980
Heading: Endocrinology Article type: Original article
Authors: Kovalenko Yu.V., Tolstokorov A.S.
Organization: Saratov State Medical University
Summary:

The extensive use of modern methods of examination (ultrasound investigation with Doppler mapping, aspiration (needle) biopsy, radiodiagnostics) cannot resolve the problem of verification of nodular mass in case of multinodular goiter before operation. Operative intervention is the method of choice in this case, which gives rise to the problem of surgery extent. The present study is useful in improvement of remote results of surgical treatment of multinodular goiter through statistical estimation of recurrent goiter development. The study was retrospective and included 102 consecutively admitted and operated patients with recurrent goiter and 102 patients of control group with first diagnosed and operated goiter. Patients of both groups were in euthyroid state. Patients were admitted to the Clinic of Surgery and Oncology of Raising Skills Faculty of Saratov State Medical University n.a. V. I. Razumovsky from 2000 till 2004. Statistical analyses included calculation of average mean, standard deviation and mean error. Student's ratio was used as the test of validity of average mean. Chi-square test was used for assessment of qualitative characteristics.

Keywords: thyroid status
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High density lipoproteins as indicators of endothelial dysfunction in children with diadetes type I

Summary:

The aim of the investigation was to study the level of blood high density lipoproteins (HDL) in the groups of children with different course of diadetes type I in order to find out the dependence of course and complications of diabetes on that level. Materials and methods: Blood high density lipoprotein (HDL) levels were investigated in children and adolescents with diadetes type I, depending on the duration of diadetes type I, age, stage of sexual development, the stage of diabetic nephropathy and levels of plasma endothelin-1 (E-1). Results: Decrease in HDL level with increasing duration of diadetes type I in prepubertate patients, higher indices of HDL cholesterol were determined in girls, especially with impaired puberty. HDL cholesterol was higher in diabetic nephropathy at the stage of proteinuria and high level of blood endothelin-1. Conclusion: The revealed changes were considered to cause deregulation of vascular endothelium as a manifestation of the initial stages of endothelial dysfunction

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Gestational diabetes mellitus: risk factors development, occurrence, diagnostics and treatment (review)

Year: 2011, volume 7 Issue: №2 Pages: 534-541
Heading: Endocrinology Article type: Review
Authors: Kostenko I.V., Rogozhina I.E., Sukhankina G.V., Ryzhkina S.A.
Organization: Saratov State Medical University, Engels Perinatal Centre
Summary:

Gestational diabetes is defined as a violation of carbohydrate metabolism resulting in hyperglycemia of varying severity, firstly revealed or developed during the pregnancy. The article presents current data on the occurrence, etiology and pathogenesis of gestational diabetes, as well as methods for screening and diagnostics of disorders of carbohydrate metabolism during pregnancy. It explains the basic principles of diet therapy

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Stressogenic aspects of diffuse toxic goiter relapse with signs of thyrotoxic myocar-dial dystrophy

Year: 2011, volume 7 Issue: №1 Pages: 174-175
Heading: Endocrinology Article type: Original article
Authors: Rodionova T.I., Onyushkina N.Yu.
Organization: Saratov State Medical University
Summary:

Probability of relapse development of diffuse toxic goiter during the nearest two years after treatment is determined by its results and stressogenic capacity level, which is defined by Holmes and Rage method. As long as satisfactory treatment results and level of stressogenic capacity are above 300 points, the risk of diffuse toxic goiter relapse run to 68,5%

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Insulinotherapy as a medico-social phenomenon and quality of life of patients with type 1 diabetes mellitus

Year: 2010, volume 6 Issue: №4 Pages: 863-866
Heading: Endocrinology Article type: Review
Authors: Kargina L.V., Dorogoykin D.L., Rodionova T.I., Utts I.A.
Organization: Saratov State Medical University
Summary:

The article examines the factors influencing availability of insulinotherapy, modern insulin types, methods of insulin administration, and insulin pump as one of its number. The authors explicate some challenges connected with availability of insulin therapy for patients with type 1 diabetes mellitus belonging to various social groups

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