Saratov JOURNAL of Medical and Scientific Research

spinal cord

Idiopathic syringomyelia with involvement of all segments of spinal cord

Year: 2019, volume 15 Issue: №1 Pages: 180-182
Heading: Neurology Article type: Case report
Authors: Sergeeva А.А., Serebrennikov N.A.
Organization: First City Clinical Hospital n.a. E.E. Volosevich of Arkhangelsk, Northern State Medical University
Summary:

Syringomyelia is a chronic disease with multiple etiologies characterized by a progressive development of longitudinal cavities within spinal cord, which are filled with cerebrospinal fluid or a liquid of similar composition. Etiologically syringomyelia is most often associated with type 2 Chiari malformation. One of the least common variants is an idiopathic syringomyelia. The article describes a rare clinical case of idiopathic syringomyelia with involvement of all spinal cord segments and the outcomes of its surgical treatment using syringo-subarachnoid shunting techinque.

AttachmentSize
2019_01-1_180-182.pdf761.43 KB

The epidemiology of spine and spinal cord injuries

Year: 2018, volume 14 Issue: №3 Pages: 592-595
Heading: Traumatology and Orthopedics Article type: Review
Authors: Tolkachev V.S., Bazhanov S.P., Ulyanov V.Yu., Fedonnikov A.S., Ninel V.G., Salikhu Kh., Norkin I.A.
Organization: Saratov State Medical University
Summary:

The article contains domestic and foreign data reflecting epidemiological peculiarities of traumatic injuries of spine and spinal cord, their character and incidence among various population groups with respect to gender and age parameters. The study outlines spine and spinal cord injury structure with regard to modern classification schemes, introduces injury incidence data, specifies indexes of lethality in spine and spinal cord injuries.

AttachmentSize
2018_3-1_592-595.pdf243.92 KB

The peculiarities of morphological differential diagnostics of intradural tumor localized at the level of medullary cone and cauda equina roots

Year: 2018, volume 14 Issue: №3 Pages: 567-570
Heading: Traumatology and Orthopedics Article type: Case report
Authors: Matveeva O.V., Bazhanov S.P., Ponomareva Е.Е., Tolkachev V.S.
Organization: Penza Regional Oncology Centre
Summary:

Aim: to demonstrate the necessity of modern methods of morphological verification in the differential diagnostics of primary and secondary neoplastic lesion of spinal cord. It is shown that histogenesis of tumor cells should be regarded from the viewpoint of comparative assessment of traditional and complementary methods of morphological verification that outlines the necessity of complex differential morphological diagnostics with apparent priority of immunohisto-chemical methods for the verification of final diagnosis of metastatic lesion in a rarely seen localization.

AttachmentSize
2018_3-1_567-570.pdf1.85 MB

Comparative retro- and prospective analysis of treatment outcomes in patients with SCI and cervical spine injuries in acute and early periods of traumatic disease

Year: 2017, volume 13 Issue: №3 Pages: 710-715
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Bazhanov S.P., Ulyanov V.Yu., Chibrikova Yu.A., Biryukova A.V., Norkin I.A., Gulyaev D.A., Salihu H.
Organization: Almazov National Medical Research Centre, Saratov State Medical University
Summary:

The aim: to conduct comparative retro- and prospective study of treatment outcomes in patients with cervical spine and SC injuries on the basis of assessment scale analysis. Material and Methods. 217 patients with closed cervical spine and SC injuries commeasurable by age, degree of neurological deficit, acute physiological and chronic state disorders were enrolled into the study. 177 patients comprised the main group (prospective study) and 40 — comparison group (retrospective study). To compare treatment outcomes we used Karnofsky score (Karnofsky, 1949), a quantitative assessment score for general patient status scales, APACHE II, Acute Physiology and Chronic State Evaluations (Knaus — Draper, 1985) and SCIM II, Spinal Cord Independence Measure Scale. Results. Comparative analysis based on the quantitative values of assessment scales, indicates an improvement of short-term treatment outcomes in patients with SC and cervical spine injuries in the main group. Conclusion. Complex approach to differentiated surgical treatment management and unique neuroprotection methods significantly improves short-term treatment outcomes having positive effect on general patient status, severity of acute physiological and chronic state disorders and patients' independence in the post-surgical period.

AttachmentSize
2017_03-2_710-714.pdf261.25 KB

Pathophysiological mechanisms of local (pulmonary) inflammatory reaction at the traumatic disease of the spinal cord

Year: 2015, volume 11 Issue: №2 Pages: 186
Heading: Traumatology and Orthopedics Article type:
Authors: Uljanov V.Yu., Drozdova G.A., Konjuchenko E.A., Opredelentseva S.V., Shchukovsky V.V., Norkin I.A.
Organization: Peoples' Friendship University of Russia
Summary:

Objective: to study pathophysiological mechanisms of local (pulmonary) inflammatory reaction in the sharp and early periods of a traumatic disease of a spinal cord on the basis of an assessment of dynamic changes of cellular structure of a bronchial secret, an alveolar epithelium and a microbic landscape of a tracheobronchial tree at patients with the complicated damages of cervical department of a backbone. Materials and methods. Methods of cytologic, immunofermental and bacteriological researches at 40 patients with the complicated damages of cervical department of a backbone to dynamics studied the contents the neutrofil of leukocytes and alveolar macrophages in a bronchial secret, a mutsin antigene 3GE5 and surfaktant protein D in serum of blood, character of microbic flora of a tracheobronchial tree and its some biological properties. Results. Activation of local (pulmonary) inflammatory reaction in the sharp and early periods of a traumatic disease of a spinal cord is characterized by increase of the contents the neutrofil of leukocytes in a bronchial secret for the 7-14th days, lymphocyts — for the 1-14th days increase in the maintenance of a mutsin antigene 3GE5 for the 14th days and SP-D —for the 1-14th days, allocation from respiratory substrata of opportunistic microorganisms in clinically significant concentration; knocking over — increase of quantity of alveolar macrophages, decrease in the maintenance of a mutsin antigene 3GE5 and SP-D for the 21-30th days and sanitation of a locus of an infection in a tracheobronchial tree. Conclusion. The pathophysiological mechanisms defining changes of cellular structure of a bronchial secret, an alveolar epithelium and a microbic landscape of a tracheobronchial tree in the sharp and early periods of a traumatic disease of a spinal cord play an important role in development of organ (pulmonary) inflammatory reaction.

AttachmentSize
2015_02_186-192.pdf326.07 KB

Nerve tissue growth factors as markers of evaluation of neuro-genesis processes in traumatic spinal cord disease

Year: 2014, volume 10 Issue: №3 Pages: 446-449
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Uljanov V.Yu., Norkin I.A., Drozdova G.A., Konjuchenko E.A.
Organization:
Summary:

Objective: immunological differentiation effects regeneration of nerve tissue in the acute and early periods of traumatic spinal cord disease on the basis of assessment of the dynamics of content neurospecific proteins in serum affected. Material and Methods. Content of neurospecific proteins in the blood serum has been studied by enzyme immunoassay in 40 patients with spinal cord injuries. Results. Dynamics and quantitative changes in the content of chronometric neurospecific proteins in serum of patients in acute and early periods of traumatic spinal cord disease is characterized by two-phase increase in the concentration CNTF; monotonic increase in the content of NT-3 in all periods of observation; biphasic increase in the levels of NT-4 to 1-4th and 14-th day from the date of injury. Conclusion. Complex research of neurospecific levels of proteins in the serum allows one to evaluate selectively the individual components of the process of regeneration of nerve tissue in acute and early periods of traumatic spinal cord disease.

AttachmentSize
2014_03_446-449.pdf281.52 KB

Dynamics of processes of free lipid peroxidation and antioxidant protection when the development of infectious-inflammatory complications in acute and early periods of spinal cord traumatic disease

Year: 2012, volume 8 Issue: №3 Pages: 734-737
Heading: Anaesthesiology and Reanimatology Article type: Original article
Authors: Ulianov V.Yu., Bazhanov S.P., Konyuchenko EA., Shchukovsky V.V.
Organization:
Summary:

Objective: to study the dynamics of individual indicators of free radical lipid peroxidation and antioxidant defense in acute and early periods of traumatic disease of the spinal cord during the development of infectious and inflammatory complications. Material and methods. An analysis of selected indicators of free radical lipid peroxidation and antioxidant protection in the development of infectious-inflammatory complications in the acute and early periods of traumatic disease of the spinal cord. In the state of the studied groups of lipid peroxydation was evaluated on the content of malon dialdehyde, antioxidant protection — at the level of ceruloplasmin and superoxidedismutase. Results. In patients with traumatic spinal cord disease in the absence of infectious and inflammatory complications revealed monophasic increase in the concentrations of the studied parameters in the 1-4th day after injury, followed by a gradual decrease in its 30th day. With the development of traumatic disease of the spinal cord is marked as a two-phase activation of the mechanisms of lipid peroxidation and antioxidant enzyme activities of systems occurring in the 1-4th and 14th day from the date of injury with a subsequent decrease in their 30th day. Conclusion. The findings suggest that differences in the metabolic response depending on the absence or presence of infectious-inflammatory process.

AttachmentSize
201203-734-737.pdf297.14 KB

Functional regulation of movements in rehabilitation of patients with spinal cord injury

Year: 2010, volume 6 Issue: №3 Pages: 628-632
Heading: Neurology Article type: Original article
Authors: Kiselev D.A., Laisheva О.А., Gubanov V.V.
Organization: Saratov State Medical University, Russian State Medical University
Summary:

The new therapeutic method of functional regulation of movements (FRM) as a part of treatment course for children with cerebral paralysis was developed. It is an individual technique of consensual work of anatomically remote muscular groups. This approach provides the influence on mechanisms of pathological activity of central nervous system by means of including deep regulating processes representing ontogenetic programs of motor activity. This technique has the advantage of immediate formation of correct motor stereotype and highly individual approach that promotes increase of therapy effectiveness

AttachmentSize
201003_628_632.pdf1.17 MB