Saratov JOURNAL of Medical and Scientific Research

alcohol

Specific complex of non-radiation risk factors for socially significant pathologies could affect the liquidators of Chernobyl nuclear power plant accident

Summary:

The review considers the complex of non-radiation factors that could affect the liquidators of the Chernobyl accident: the demographic, social and professional group heterogeneity to warrant differentiation of risk, the effects of heavy metals, 'hot particles', chemicals, psychogenic stress, social dislocation in the post-perestroika period, alcohol abuse, smoking, and the effect of screening. All these factors tend to have a significant intensity, unlike the radiation exposure for the majority of subjects. It is concluded that the increased frequency and severity of some large socially significant pathologies in contingent liquidators may be due to a unique set of predominantly non-radiation factors associated, however, with a particular radiation accident.

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Increased serum homocysteine levels and glutathione-S-transferase activities in alcoholic patients attending de-addiction centre

Year: 2010, volume 6 Issue: №3 Pages: 620-624
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Kulkarni S.R., Ravindra К.Р., Dhume С., Rataboli P.V., Rodrigues E., Rodrigues E.E.
Organization: India, Mumbai-8, Byculla, Grant Medical College & Sir J.J. Group of Hospital, India, Mumbai- 400 098, Kalina, University of Mumbai, India, Goa 403 202, PO. Bambolim Complex, Goa Medical College
Summary:

The purpose of this study was to investigate the effect of heavy alcohol consumption on serum Malondialdehyde, homocysteine status and glutathione-S -transferase (GST) activities in alcoholics consuming illicit liquor from lower socioeconomic background attending deaddiction centre. The study was conducted in ninety alcoholic patients consuming illicit liquor from lower socio-economic background attending de-addiction centre and compared to healthy non alcoholic controls (n=90). Serum Malondialdehyde (MDA), serum homocysteine and activities of antioxidant enzyme glutathione-S - transferase (GST) were estimated. Alcoholics consuming illicit liquor attending de-addiction centre displayed significantly higher values of serum MDA concentration, serum homocysteine levels and serum GST activities as compared to their non alcoholic healthy controls belonging to the same socio-economic background. Our results indicate that increase in serum Malondialdehyde (MDA) concentration marker of oxidative stress, serum homocysteine levels and serum glutathione-S-transferase (GST) activities may enhance the susceptibility to vascular diseases in heavy illicit drinkers with poor nutritional status

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