Saratov JOURNAL of Medical and Scientific Research

Kemerovo Children Hospital № 5

Indicators of allogenic interactions of lymphocytes in spouses as additional diagnostic and prognostic criteria of immune forms of reproductive failures

Year: 2013, volume 9 Issue: №4 Pages: 649-652
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Belenkova O.V., Mozes V.G., Shabaldin A.M., Lisachenko G.V.
Organization: Kemerovo Children Hospital № 5, Kemerovo State Medical University
Summary:

Research objective: to search new laboratory approaches to the diagnostics of immune forms of reproductive failures. Materials and methods. Retrospective research a case — control of 54 married couples with idiopathic reproductive failures (in the anamnesis — 3 and more spontaneously interrupted pregnancy in the 4-8th weeks) and 47 married couples having two and more children has been conducted. Results. It has been revealed that at the immune form of reproductive failures increase of cells of level A- mononuclear cells, expression of HLDR takes place that promotes tolerance cancellation to allogenic germs and to immune interruption of pregnancy. At reproductive failures female au-toserum positively influences activation of T-lymphocyte (CD3 +/HLADR +) that may lead to the death of half- allogenic germ. Conclusion. Level of expression of CD3 and HLADR on CD45 + of mixed allogenic mononuclear cells of spouses may serve as a diagnostic significant criterion for revealing immune reasons of reproductive failures.

AttachmentSize
2013-04_649-652.pdf793.74 KB

Clinical predictors of adverse course of nonspecific bacterial vulvovaginitis at girls born from mothers with dysplasia of connective tissue

Year: 2012, volume 8 Issue: №2 Pages: 214-218
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Kosykh S.L., Mozes V.G.
Organization: Kemerovo State Medical University, Kemerovo Children Hospital № 5
Summary:

Research objective: To define clinical predictors of adverse course of nonspecific bacterial vulvovaginitis (NBV) at girls born from mothers with the undifferentiated forms of dysplasia of connective tissue (UFDCT). Materials: At 157 girls clinical research, bacteriological and bacterioscopy research of leucorrhoea from vagina has been conducted, NBV has been diagnosed at 111 girls. At all girls and at their mothers the immunity has been investigated; at all mothers of girls with NBV phenotypic reveals of UFDCT have been found out. Results: At girls with NBV born from mothers with UFDCT severe course of a disease has been marked; and at mothers with UFDCT and at their children with NBV disorders of humoral immunity have been revealed. Presence of more than 5 stigmas of dysembryogenesis with prevalence of thoracodiaphragmatic, articular, cosmetic syndromes and pathology of organs of vision at mothers of girls with NBV is possible to use as predictors of adverse course of the disease

AttachmentSize
201202_214-218.pdf295.66 KB

Состояние фетоплацентарной системы у беременных с недифференцированными формами дисплазии соединительной ткани, носителей семейства герпес-вирусов

Year: 2010, volume 6 Issue: №3 Pages: 531-535
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Dorohova L.N., Shaboldin A.M., Narolenko L.N., Mozes V.G.
Organization: Kemerovo State Medical University, Kemerovo Clinical Hospital № 3 n.a. M.A. Podgorbunsky, Kemerovo Children Hospital № 5
Summary:

The research goal is to determine the risk of infectious process development in placenta of women with undifferenti-ated forms of dysplasia of connective tissue (UFDCT) by agents - herpes viruses (VHG - virus of herpes simplex and cytomegalovirus).
Persistent infection of VHG was revealed in 133 women in the 1 st trimester of pregnancy. All the patients had phe-notypic manifestations of UFDCT; in the 3d trimester of pregnancy immunogram of the second level, histological study of placenta, identification of antigens of VHG family, serological study of placental blood and isolation of DNA of VHG were carried out. All newborns were clinically and laboratory tested on VHG infection.
As pregnant women with UFDCT had high risk of VHG infection development in placenta, they suffered from placental insufficiency. It resulted in unfavourable perinatal outcomes. VHG infection development was caused by disturbances of cellular immunity.
Key words: undifferentiated forms of dysplasia of connective tissue, virus of herpes simplex, cytomegalovirus, cellular immunity, pregnancy

AttachmentSize
201003_531_535.pdf271.13 KB