Saratov JOURNAL of Medical and Scientific Research

Chuvash State University n.a. I.N. Ulyanov

Neuroamines — regulators of local processes at bone marrow autotransplantation

Year: 2015, volume 11 Issue: №4 Pages: 524-526
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Vorobyova O.V.
Organization: Chuvash State University n.a. I.N. Ulyanov
Summary:

Purpose: to determine the content of neuroamines (histamine, serotonin, catecholamines) in bioamine structures of bone marrow after autotransplantation. Material and methods. Animals were injected into the tail vein of bone marrow suspension obtained from the femur of the same mouse. It was taken from the femoral bone marrow of 1 ml and placed in 2 ml of physiological saline and thoroughly stirred. 1 ml of bone marrow suspension was injected into the tail vein. Cryostat sections were treated with luminescent-histochemical methods. Results. After bone marrow autotransplantation marked changes were observed in the neurotransmitters of the bone marrow — an increasing number of granular luminescent cells decrease in the amount of granules in them, and a decrease in the number of mast cells because of their degranulation. A weak luminescence was determined in nuclei in neutrophils. Perhaps this proves the activation of the immune response. Conclusion. The bone marrow autotransplantation leads to a redistribution of the structures of the bone marrow of histamine, catecholamines and serotonin, which changes the direction of cytodifferentiation, the content of neuroamines in granular luminescent cells and mast cells (cells of autonomic regulation).

AttachmentSize
2015_04_524-526.pdf290.2 KB

Comparative characteristics of mammary glands cancer in humans and animals

Year: 2012, volume 8 Issue: №3 Pages: 706-711
Heading: Physiology and Pathophysiology Article type: Review
Authors: Vorobyova О.V., Terentyuk G.S., Bucharskaya A.B.
Organization: Saratov State Medical University, Chuvash State University n.a. I.N. Ulyanov
Summary:

This review is devoted to a comparative analysis of receptor status, immunity, angiogenesis, metastatic mammal glands cancer expression profiling in humans and animals. Angiogenesis has been assessed by quantitative and immunohistochemical characteristics by means of evaluation of microvascular density (MVD) using Claudin-5 (CLDN-5) as a marker of vascular endothelium in tumors of mammary glands in dogs.

AttachmentSize
201203-706-711.pdf445.37 KB

Risk factors of children birth with delay syndrome of prenatal development

Year: 2010, volume 6 Issue: №3 Pages: 528-530
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Bushuyeva E.V., Denisova T.G., Gerasimova L.I., Smirnova E.I.
Organization: Chuvash State University n.a. I.N. Ulyanov
Summary:

Purpose: revealing of medical and biological, medical and social, medical and organizational risk factors of a birth mature children with a delay syndrome of prenatal development.
The basic group included women who have given birth to mature child with a delay syndrome of prenatal development (body weight at a birth less 3000gr) - 60 observations; control group consisted of women who have given birth to children with weight from 3000 to 4000gr (total N=100).
Anamnesis of life and pregnancy of women given birth to mature children with the delay syndrome of prenatal development have been analyzed.
Conclusion: Medical and biological, medical and social risks of birth to mature children with low weight less than 3000 gr have been determined. Low weight of mature child is the risk factor of cardiac and metabolic diseases

AttachmentSize
201003_528_530.pdf272.01 KB