Saratov JOURNAL of Medical and Scientific Research

Pavlenko N.N.

Scientific Research Institute of Traumatology, Orthopedics and Neurosurgery of Saratov State Medical University n.a. V. I. Razumovsky, Department of Innovative Projects in Traumatology and Orthopedics, Leading Research Assistant, Professor, Doctor of Medical Sciences

Biomechanical criteria of orthopedic status of patients with dysplastic coxarthrosis (Crowe) IV before and after treatment

Year: 2017, volume 13 Issue: №3 Pages: 520-526
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Yusupov K.S., Barabash Yu.A., Pavlenko N.N., Romakina N.A., Anisimova E.A., Letov A.S., Sertakova A.V., Anisimov D.l.
Organization: Scientific Research Institute of Traumatology Orthopedics and Neurosurgery of Saratov State Medical University n.a. V.I. Razumovsky
Summary:

The aim: to analyze locomotor function of lower limbs in patients with dysplastic coxarthrosis Crowe IV type before and after single-step hip joint endoprosthesis and femoral bone osteotomy conducted by our own technology. Material and Methods. 42 patients with one-side dysplastic coxarthrosis Crowe IV type were examined and operated. The mean age at the time of admission in men was 47.3±1.2 years, women — 46.1 ±1.1 years. Static and kinematic function of lower limbs was evaluated with the help of stabilometrics and podometry before and one year after the operation. Results. Before treatment, the patients had deviations of static and dynamic function of locomotor system stabilometri-cally seen as instability in upright position and podographically as a compromised gait. One year postsurgically we indicated static balance between the limbs within the normal range, expanded motoring mode, which was supported by significant improvement in the biomechanical characteristics of locomotor function of the patients. Conclusion. Total hip replacement in combination with modifying osteotomy of the hip conducted by a unique technique restores static and kinematic function of lower limbs in patients with high congenital hip dislocation (dysplastic coxarthrosis Crowe type IV) which is proved by stabilographic and podographic indices one year after operation.

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Concentration of MMP-9, TNF-a and IL-6 in patients with tumors and tumor-like bone lesions

Year: 2017, volume 13 Issue: №3 Pages: 506-510
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Puchinyan D.M., Pavlenko N.N., Korshunov G.V., Galashina E.A., Gladkova EV.
Organization: Scientific Research Institute of Traumatology Orthopedics and Neurosurgery of Saratov State Medical University n.a. V.I. Razumovsky
Summary:

Aim: to determine the concentration of MMP-9, TNF-a and IL-6 in blood serum of patients with benign and malignant bone tumors and feasibility of cytokine data use for differential diagnostics of the neoplastic process nature. Material and Methods. Levels of matrix metalloproteinase-9 (MMP-9), tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) in blood serum were determined by the immunoenzyme method in 64 patients with bone tissue neoplasms (fibrous dysplasia, osteocystoma, giant-cell tumor, osteosarcoma, chondrosarcoma, bone metastases, multiple myeloma). Re-sults. MMP-9 level was heightened in patients suffered from chondrosarcoma and multiple myeloma. TNF-a and IL-6 expression was increased in cases with bone metastases. MMP-9, TNF-a and IL-6 levels were higher in cases with malignant bone neoplasms than in cases with benign bone tumors. Conclusion. MMP-9, TNF-a and IL-6 participate in the neoplastic process pathogenesis directly. Nevertheless it is too early to speak about the diagnostic value of the cytokines in cases with tumorous bone affection.

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Morphological studies in the diagnosis of primary and secondary bone tumors

Year: 2016, volume 12 Issue: №4 Pages: 566-570
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Matveeva O.V., Zhandarova L.F., Pavlenko A.A., Kesov L.A.
Organization: Saratov State Medical University
Summary:

The aim: to show the possibility of morphological studies in the diagnosis of primary and secondary tumors of bones. Material and Methods. 105 (72%) patients with primary bone tumors aged from 15 to 66 years and 42 (28%) patients with metastatic bone lesions aged from 42 to 70 years were examined and treated for the period from 2008 till 2015. Material for morphological studies was prepared using an open biopsy tissue slices and a scraping resected tumor during surgery. Soft-tissue component is subjected to cytology. The material for histological study included changes in bone and soft tissue. Results. Giant cell tumor was verified in 45% of cases by histological examination. Multiple myeloma was diagnosed in 15% of patients. Osteogenic sarcoma was diagnosed in 14% of cases. Ewing's sarcoma was diagnosed in 3%, 2% of cases were matched by diagnosed chordoma. According to the data received, cancer metastasis of kidney and lung is mostly diagnosed in men from the group of patients with secondary bone defeat. Metastasis of cancer of the breast in women was predominated. Conclusion. The morphological (histological, cytological) study plays an important role in the diagnosis of bone tumors. The coincidence of the cytological and histological diagnoses was 97%.

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Biomarkers content in blood serum of patients with osseous neoformations

Year: 2016, volume 12 Issue: №3 Pages: 358-361
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Korshunov G.V., Pavlenko А.А., Puchinyan D.M., Shakhmartova S.G.
Organization:
Summary:

The aim of the study was the estimation of several biomarkers in differentiation diagnostics of tumour diseases in osseous system. Material and methods. 160 patients with benign (115) and malignant (45) osseous neoformations were investigated. Neopterine, tumour necrosis factor (TNF-а), interleukin-6, adhesion molecules of vessel endothe-lium (sVCAM-1) and vascular endothelial growth factor (VEGF) levels were identified by ELISA solid-phase test and compared with the levels of 20 apparently healthy individuals. Tumor verification was fulfilled by X-ray, CT, MRI and histomorphological essay. Results. Both benign and malignant osseous tumour patients showed increased levels of neopterine, TNF-а and interleukin-6 being more significant with malignant processes. The level of sVCAM was decreased in patients of both groups and VEGF level corresponded to the control, these indexes did not show any differences between the groups. The assessment of diagnostic value of these cytokines indicates that positive results for TNF and neopterine give the ground for the final diagnostic decision while the same results for interleukin-6 give moderate basement for diagnostic decision. Conclusion. Increased TNF-а and neopterine levels allow substantiating the difference between benign and malignant osseous tumours and improving diagnostic quality.

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The access dependence of endoprosthetic ball dislocation in hip replacement

Year: 2016, volume 12 Issue: №2 Pages: 175-181
Heading: Traumatology and Orthopedics Article type: Review
Authors: Abdulnasyrov R.K., Kireev S.I., Markov D.A., Yusupov K.S., Letov A.S., Frolenkov A.V., Pavlenko N.N.
Organization: Saratov State Medical University
Summary:

In the course of the study the foreign and native publications concerning total hip replacement have been analyzed. The data from National Registers of various countries are presented in the study. They highlight some issues upon total hip replacement, technologies of surgical intervention advancing and most important risk factors for endoprosthetic ball dislocation.

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X-ray, anatomical and biomechanical features in patients with developmental hip dislocation

Year: 2014, volume 10 Issue: №1 Pages: 114-119
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Yusupov K.S., Anisimova Е.А., Pavlenko N.N., Letov A.S., Zaychev V.A., Emkyzhev O.L., Zotkin V.V., Markov D.A.
Organization: Saratov State Medical University
Summary:

The Pupose: to analyze X-ray, anatomical and biomechanical features in patients with developmental hip dislocation. Material and Methods. The study included 73 patients (57 women and 16 men) with the developmental hip dislocation at the age of 31 to 76 years. The clinical method, X-ray, gait analysis and visual analogue scale VAS, McGill inquiry. Results. The comparative analysis of X-ray, anatomic and biomechanical features in patients with different severity of developmental hip dislocation. Conclusion. Features of the functional status of patients with different severity of developmental hip dislocation enable to predict the tactics of surgical treatment and individual rehabilitation program.

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Revision hip endoprosthesis peculiarities after removal of costruc-tions fixed by screw thread

Year: 2010, volume 6 Issue: №2 Pages: 421-423
Heading: Traumatology and Orthopedics Article type: Original article
Authors: P.A. Zuev, N.N. Pavlenko, M.A. Saakyan, P.P. Zuev
Organization: Saratov State Medical University, Saratov Scientific Research Institute of Traumatology and Orthopedics
Summary:

The given article concerns with revision hip replacement performed by the construction fixed in intramedullary canal of femur, due to the screw thread applied on the surface of the prosthesis. The example of two-phase hip replacement after the removal of such construction is under the study

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