Saratov JOURNAL of Medical and Scientific Research

Review

Migraine and epilepsy: comorbidity and problems in diagnostics

Year: 2019, volume 15 Issue: №1 Pages: 154-158
Heading: Neurology Article type: Review
Authors: Kalinin V.A., Poverennova I.E., Yakunina A.V., Myakinina A.E.
Organization: Samara State Medical University
Summary:

The purpose of this review is to carry out the analysis of published data on comorbidity of migraine and epilepsy. The review is based on results of epidemiological and genetic studies. Clinical manifestations of two diseases are in many respects similar, which sometimes leads to considerable difficulties in diagnostics. Differential diagnosis is based on careful analysis of clinical manifestations, electroencephalography and neuroimaging data. Genetic forms of epilepsy are often accompanied by migrainous headaches. The unity of some pathophysiological mechanisms of epilepsy and migraine predefines comorbidity and directions of diagnostics and treatment for both diseases. Nevertheless, there is a number of questions which demand more precise answers to improve diagnostics and treatment.

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Current state and prospects of antibiotic prophylaxis in patients after burn injury

Year: 2019, volume 15 Issue: №1 Pages: 108-113
Heading: Parmacology Article type: Review
Authors: Barsuk A.L., Lovtsova L.V., Nekaeva E.S., Sorokina Yu.A.
Organization: Privolzhskiy Research Medical University
Summary:

The review is devoted to antibiotic prophylaxis of infectious complications in burns. Severe burn injury often results in death. Infectious complications are the most common cause of mortality in these patients. Systemic antibiotic prophylaxis is actively used in practical medicine, but is not recommended by national and international clinical guidelines for the treatment of patients affected by burns. The principles of such prevention have not been developed yet. The data of studies of systemic antibiotic prophylaxis are inconsistent. A number of studies confirm the rationality of use of systemic antibiotic prophylaxis in persons on artificial ventilation with severe burns. This approach has been reported to reduce mortality and incidences of pneumonia significantly. There are evidences of perioperative antibiotic prophylaxis effectiveness in some surgical procedures associated with burn injury. Studies also demonstrate antibiotic prophylaxis and intestine decontamination combination effectiveness in preventing from complications in burn patients. Besides antibiotic prophylaxis, other pharmacological approaches currently are being developed in order to reduce the incidence of infectious complications in burns. Preclinical studies have shown the effectiveness of statins and topical probiotics in the prevention of burn sepsis in the experiment. The development and implication of early diagnostic methods for infectious complications is one another possible way to prevent severe infections in patients with burn injury.

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Features of angiogenesis in skin tissue regeneration

Year: 2019, volume 15 Issue: №1 Pages: 104-107
Heading: Physiology and Pathophysiology Article type: Review
Authors: Pronina Е.А., Stepanova T.V., Kiriyazi T.S., Maslyakov V.V., Ivanov A.N.
Organization: Saratov Medical University "Reaviz", Saratov State Medical University, Saratov State Technical University n.a. Yu.A. Gagarin
Summary:

Restoration and regeneration of tissues are complex processes involving a large number of signaling mechanisms. In this study possible mechanisms of angiogenesis during tissue regeneration are presented. One of these mechanisms is the creation of a new capillary layer by angiogenesis. Previously it was believed that high and rapid levels of capillary growth are necessary for optimal healing of tissues. But several studies have demonstrated that a period of vascular regression occurs after the growth of blood vessels in a wound, and the number of the newly formed vessels decreases until the number of the blood vessels is equal to the density of the vascular network in the intact tissue. Reduced inflammation and angiogenesis are features of optimal healing.

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Local effect of vitamin D on the immune system of periodontium

Year: 2019, volume 15 Issue: №1 Pages: 41-47
Heading: Stomatology Article type: Review
Authors: Ostrovskaya L.Yu., Zakharova N.B., Bodyleva А.Р., Bulkina N.V., Lysov A.V., Osipova U.L.
Organization: I.M. Sechenov First Moscow State Medical University, Saratov State Medical University
Summary:

 Literature review is devoted to the analysis of scientific findings about extraosseous effects of vitamin D on the immune system of the periodontal tissues. It was found that the biological functions of vitamin D (VD) in the body are diverse.Along with the detailed study of the effect on metabolic processes in bone tissue, VD makes a significant contribution to a large number of processes that ensure the activity of the immune system. In addition, VD increases the production of "endogenous antibiotics". This allows us to consider VD as a therapeutic agent that prevents the development of inflammatory and destructive changes in the periodontal tissues in population with simultaneous slowing of bone loss and preservation of bone mass of the dentofacial system. Currently detected hidden hypovitaminosis VD in almost majority of the population is considered a leading factor in the development of periodontal disease and its prevention and treatment is one of the most important tasks of therapeutic dentistry.

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Preventive care for the patients with chronic kidney disease in the Russian Federation: analytical review of the prevalence and existing programs

Year: 2019, volume 15 Issue: №1 Pages: 24-28
Heading: Internal Diseases Article type: Review
Authors: Milchakov K.S., Shilov Е.М., Gabaev M.l.
Organization: I.M. Sechenov First Moscow State Medical University
Summary:

This article aims to provide an analytical review of existing organizational and methodological approaches to the prevention and control of chronic kidney disease (CKD) in the Russian Federation. Various aspects of the current situation of CKD in the Russian Federation are considered and national institutional mechanisms applicable to this state are analyzed. Despite the obvious positive developments in the prevention of noncommunicable diseases in the Russian Federation, the problem of CKD in Russia is not sufficiently covered as a result of this situation there is personnel and methodological deficit, weak interdisciplinary interaction of health care organizations, as well as underreporting of specific nephrological risks of CKD progression.

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Pregnancy and cervical intraepithelial neoplasia

Year: 2019, volume 15 Issue: №1 Pages: 19-23
Heading: Obstetrics and Gynecology Article type: Review
Authors: Yakovleva O.V., Glukhova T.N., Rogozhina I.E., Skupova I.N.
Organization: Saratov State Medical University
Summary:

The review of literature is devoted to the problem of cervical intraepithelial dysplasia in pregnant women. For the analysis, publications in the PubMed from 2013 till 2018 database were used.

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Modern approaches to treatment of uveitis in systemic diseases of connective tissue

Year: 2018, volume 14 Issue: №4 Pages: 956-960
Heading: Ophtalmology Article type: Review
Authors: Kamalova K.B., Zakirkhodjayev R.A., Asrorkhodjayeva I.R.
Organization: Tashkent Medical Academy
Summary:

 Uveitis can develop in various systemic diseases of connective tissue. This article provides data on modern methods of treatment for such cases of uveitis. Uveitis in systemic diseases of the connective tissue develops due to violations of cellular and humoral immunity. Given the pathogenesis of the primary disorder, treatment of uveitis in systemic diseases of connective tissue involves use of cytotoxic drugs, TNFa inhibitors, cytokines, antibodies to lymphocyte surface antigens, and immunoglobulins. Due to the chronic course of the disorder and frequent relapses, it is advisable to use local and systemic glucocorticoid drugs with prolonged effect. The combined corticosteroid drug diprospan containing the two active ingredients of betamethasone provides a combination of immediate and prolonged effects, thereby improving patient's clinical condition and prolonging the period of remission.

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Bacterial collagenase in the treatment of vitreoretinal pathology

Year: 2018, volume 14 Issue: №4 Pages: 953-956
Heading: Ophtalmology Article type: Review
Authors: Zgoba M.l., Lyskin P.V., Makarenko I.R.
Organization: The S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

Bacterial collagenase has been used in Russian ophthalmology for more than 40 years, its official medical use is allowed since 1983 Collagenase is used in the treatment of a broad spectrum of ophthalmopathology For the treatment of vitreoretinal pathology the drug has been used since 1996 To date, quite a lot of experience in the use of bacterial collagenase for the treatment of vitreoretinal pathology has been accumulated. The article presents the literature data on the possibilities of using the drug in various areas of vitreoretinal pathology and the prospects of expanding the indications for the use of the drug in a wider ophthalmic practice.

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Bacterial collagenase in the treatment of vitreoretinal pathology

Year: 2018, volume 14 Issue: №4 Pages: 953-956
Heading: Ophtalmology Article type: Review
Authors: Zgoba M.l., Lyskin P.V., Makarenko I.R.
Organization: The S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

Bacterial collagenase has been used in Russian ophthalmology for more than 40 years, its official medical use is allowed since 1983 Collagenase is used in the treatment of a broad spectrum of ophthalmopathology For the treatment of vitreoretinal pathology the drug has been used since 1996 To date, quite a lot of experience in the use of bacterial collagenase for the treatment of vitreoretinal pathology has been accumulated. The article presents the literature data on the possibilities of using the drug in various areas of vitreoretinal pathology and the prospects of expanding the indications for the use of the drug in a wider ophthalmic practice.

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Comorbidity of diseases of the cardiovascular system and primary open-angle glaucoma

Year: 2018, volume 14 Issue: №4 Pages: 949-953
Heading: Ophtalmology Article type: Review
Authors: Zagidullina A.Sh., Latypova Е.А., Nugmanova A.R.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

This literature review examines the potential diagnostic contribution of syndromes and cardiovascular diseases: hypertension, atherosclerosis, vascular dystonia, and cerebrovascular pathology in the development of primary open-angle glaucoma (POAG). The study of relationships is relevant due to the commonality of some pathogenetic factors of POAG and these diseases and syndromes. It is necessary to take into account the effect of comorbid pathology in the early diagnosis of POAG, which will improve its quality, and the correction of associated disorders will contribute to the effectiveness of complex treatment of the disease.

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