Saratov JOURNAL of Medical and Scientific Research

Review

Irritable bowel syndrome: epidemiological and pathogenetic aspects

Year: 2018, volume 14 Issue: №1 Pages: 53-60
Heading: Internal Diseases Article type: Review
Authors: Tikhonova Т.А., Kozlova I.V.
Organization: Saratov State Medical University
Summary:

The literature review focuses on some epidemiological aspects, molecular-genetic predictors of irritable bowel syndrome formation, the role of psychosocial and infectious factors, low-grade inflammation, imbalance between neu-rotransmitters and cytokines, as well as changes in the intestinal microbiome in the development of irritable bowel syndrome.

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Anatomy of the posterior communicating artery

Year: 2018, volume 14 Issue: №1 Pages: 25-29
Heading: Human anatomy Article type: Review
Authors: Fomkina О.А., Nikolenko V.N., Gladilin Yu.A.
Organization: First Moscow State Medical University n.a. I.M. Sechenov, Saratov State Medical University
Summary:

Purpose: to generalize and systematize the information available in the literature about the anatomy of the posterior connective arteries in adults. Scientific works (monographs, articles, dissertations and abstracts of dissertations) of native and foreign authors for the period from 1928 to 2017 were worked out to achieve the goal. Data on the variants of artery discharge, areas of blood supply and major anomalies are presented. The size characteristics of arteries (length, outer diameter, wall thickness and lumen diameter) are presented taking into account bilateral, age and sexual differences.

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Some approaches in assessing effectiveness of rehabilitation activities in highly qualified athletes

Year: 2017, volume 13 Issue: №4 Pages: 947-955
Heading: sports medicine Article type: Review
Authors: Goloborodko Е.М., Fomkin P.A., Petrova V.V., Razinkin S.M.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

An overview of literature data on the types of medical rehabilitation applied to highly skilled athletes and on ways to assess the effectiveness of the implemented measures is provided in the article. Sport rehabilitation is a separate type of activity for which a conceptual apparatus should be formed; basic methodological approaches should be developed and implemented. In addition to physical rehabilitation, attention should also be given to the psychological athlete recovery, both in the context of accelerating recovery, and to strengthen adherence to the applied procedures. All rehabilitation programs should be developed individually, taking into account the specific kind of the sport. The approach based on the use of the scale of assessing the level of health in combination with an objective diagnosis of his psychoemotional state allows to fully assess the effectiveness of carrying out rehabilitation measures among highly qualified athletes

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Primary hyperpara-thyroidism: current state of the problem

Year: 2017, volume 13 Issue: №4 Pages: 849-853
Heading: Surgery Article type: Review
Authors: Kovalenko Yu.V., Tolstokorov A.S., Rossolovsky A.N., Kravchenya A.R., Manakhov G.A., Velikanova M.G.
Organization: Saratov State Medical University
Summary:

 The review is devoted to current state of the problem of primary hyperparathyroidism. One of the important steps in the study of pathology of parathyroid glands and their decision value in development of primary hyperparathyroidism was introduction of automated screening of the ionized calcium of plasma of blood to all patients asking for medical care. Understanding of the nature of this process allowed the doctors of many specialities to unite the efforts in the analysis of results of the already accumulated experience and extend possibilities of early preclinical exposure of this disease.

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Platelet indices as markers of platelet turnover and aggregation: pathophysiological interpretation, clinical impact, perspectives in research

Year: 2017, volume 13 Issue: №4 Pages: 813-820
Heading: Internal Diseases Article type: Review
Authors: Malinova L.I., Furman N.V., Dolotovskaya P.V., Puchinyan N.F., Kiselev A.R.
Organization: Saratov State Medical University n.a. V.I. Razumovsky Research Institute of Cardiology
Summary:

The purpose of the review is to characterize existing in open access bibliographical databases such as eLibrary and PubMed evidence on clinical impact of morphometric platelet indices as markers of platelet aggregation ability and turnover as a methodology and theoretical framework of further investigation. Studies results were pooled from open access bibliographic databases (eLibrary, and PubMed) according to modified PRISMA algorithm. Relevant studies were identified by systematic searches of the original studies published during the last 10 years in the Russian and English languages. Results of 96 original studies in accordance with inclusion criteria were published during the last 10 years in scientific journals indexed in eLibrary, and PubMed. The majority of publications (64.58%) consist of evidence pro diagnostic and prognostic significance of platelet indices. Studies demonstrating the significance of platelet indices as possible risk markers of thrombotic events in cardiovascular patients were predominating among "pro" publications. In 15.63% published results contradict concept of platelet indices usefulness as diagnostic and prognostic markers in clinical practice. Morphometric platelet indices can be considered as useful diagnostic and prognostic markers of thrombotic events in cardiovascular patients. Existing gaps in evidence suggest the need of further investigations.

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Interdisciplinary aspects of rehabilitation of patients with oncological diseases in non-terminal situation of the disease

Year: 2017, volume 13 Issue: №4 Pages: 806-808
Heading: Health Service Organization Article type: Review
Authors: Shmerkevich А.В., Vodolagin A.V., Balakina D.D.
Organization: Saratov State Medical University
Summary:

Medical social rehabilitation of patients with oncological diseases in the non-terminal stage of the disease is based on the principle of an interdisciplinary approach, which involves complex special treatment, providing patients and their families with various types of social and psychological support at all stages of specialized care. The authors of the review consider the solution of medical and social problems in the rehabilitation of patients with oncological diseases in the context of the synergistic effect. Weak social and psychological protection of patients with oncological pathology adversely affects the prognosis of the disease and worsens patients quality of life. The review provides evidence that patients who receive social support are best adapted to the cancer situation, while a lack of social support is a significant risk factor for increased mortality in cancer patients.

Keywords: quality of life
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Coxar-throsis in infancy and adolescence: opportunities of preventive treatment

Year: 2017, volume 13 Issue: №3 Pages: 751-755
Heading: Traumatology and Orthopedics Article type: Review
Authors: Norkin I.A., Sertakova A.V., Rubashkin S.A., Zotkin V.V., Gerasimov V.A., Timaev M.Kh., Chibrikova Yu.A., Kupina E.S.
Organization:
Summary:

The review systematizes scientific data on the major groups of heterogeneous diseases which have infant and adolescence coxarthrosis as their outcome and contains materials on etiology, pathogenesis, diagnostic, treatment and precaution methods of complication (dystrophic changes in hip joints) for each disease.

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Photodynamic therapy of psoriasis

Year: 2017, volume 13 Issue: №3 Pages: 678-681
Heading: Dermatovenerology Article type: Review
Authors: Utz S.R., Dobdina A.Ju., Talnikova Е.Е., Utz I.A.
Organization: Saratov State Medical University
Summary:

The review presents literature data on the use of photodynamic therapy in the treatment of psoriasis. In addition, the article discloses aspects of the mechanism of action, indications and contraindications, as well as the development of possible side effects when using this phototherapeutic technique.

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Assessment of the efficiency of cyclosporine use in psoriasis

Year: 2017, volume 13 Issue: №3 Pages: 673-678
Heading: Dermatovenerology Article type: Review
Authors: Kruglova L.S., Ponich E.S., Osina A.V., Gryazeva N.V.
Organization: Central State Medical Academy of the ADP of the Russian Federation
Summary:

The article presents a review of randomized studies involving patients with severe psoriasis, which showed that after 10-12 weeks of monotherapy with cyclosporine there was a decline of the Index of prevalence and severity of psoriasis (PASI). After achieving clinical remission must be decided on a gradual reduction of the dose of cyclosporine to the lowest effective dose, or the complete abolition of the medication. Simultaneous use of cyclosporine and UVB at the moment is not widely studied. Combined use of methotrexate and cyclosporine has been used successfully in the treatment of rheumatoid and psoriatic arthritis. The combined intake of cyclosporine and systemic biological agents should be used in exceptional cases of severe forms of psoriasis, not amenable to other treatments, and only for a limited period of time.

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Vitiligo: modern methods of therapy

Year: 2017, volume 13 Issue: №3 Pages: 668-673
Heading: Dermatovenerology Article type: Review
Authors: Talnikova Е.Е., Svenskaya Yu.l., Dobdina A.Ju., Fatakhova Kh.V., Utz S.R.
Organization: Saratov State Medical University, Saratov state university
Summary:

This brief review focuses on the main issues of vitiligo treatment. The article provides insight into modern methods of dermatosis therapy discussing their potential, efficiency, safety, as well as represents a variety of standard treatment regimens.

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