Saratov JOURNAL of Medical and Scientific Research

inflammation

Pathophysiological evaluation of common neonatal factors of the pathogenesis of hemolytic anemia and infammation

Year: 2019, volume 15 Issue: №2 Pages: 372-376
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Geraskin V.A., Potemina T.E., Geraskin I.V., Komlev D.Yu.
Organization: Privolzhskiy Research Medical University
Summary:

Objective: to determine the damage of blood elements as tissue damage — to study hemolytic anemia from the position of infammation. Material and Methods. Clinical and laboratory data of 187 neonatal patients were included in the examination group. The dynamics of blood erythrocyte indices was studied taking into account the dependence on age, anthropometric parameters, the severity of diseases and the intensity of oxygenotherapy. The composition and features of oxidative modifcations of lipid structures of biological membranes of erythrocytes were investigated. Results. The values of the elements of alteration in the pathogenesis of hemolysis were determined. Changes of erythrocyte membranes in oxidative hemolysis were investigated. The review and comparison of the information contained in the classical and periodicals on pathological physiology, Hematology. Conclusion. The study damage to the blood elements as tissue damage allows you to apply for the study of hemolytic anemias the concept of development of infammation.

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Irritable bowel syndrome: epidemiological and pathogenetic aspects

Year: 2018, volume 14 Issue: №1 Pages: 53-60
Heading: Internal Diseases Article type: Review
Authors: Tikhonova Т.А., Kozlova I.V.
Organization: Saratov State Medical University
Summary:

The literature review focuses on some epidemiological aspects, molecular-genetic predictors of irritable bowel syndrome formation, the role of psychosocial and infectious factors, low-grade inflammation, imbalance between neu-rotransmitters and cytokines, as well as changes in the intestinal microbiome in the development of irritable bowel syndrome.

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Molecular and genetic predisposing factors of comorbidity of fatty liver disease and diseases of the colon

Year: 2017, volume 13 Issue: №1 Pages: 029-034
Heading: Internal Diseases Article type: Review
Authors: Lapteva Е.А., Kozlova I.V.
Organization: Saratov State Medical University
Summary:

The literature review is devoted to the universal molecular markers and predictors of forming non-alcoholic fatty liver disease and pathology of the colon, the role of insulin resistance as one of the factors of the pathogenesis of non-alcoholic fatty liver disease in the development of colorectal cancer. The mechanisms of diseases of the colon (colorectal cancer) are found out to be due to non-alcoholic fatty liver disease.

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The diagnostic importance of biomarkers of angio-genesis and inflammation at patients with prostate diseases

Year: 2016, volume 12 Issue: №4 Pages: 593-598
Heading: Urology Article type: Original article
Authors: Popkov V.M., Zakharova N.B., Ponukalin A.N., Tonkoschkur A.N.
Organization: Saratov State Medical University
Summary:

Purpose: to establish the nature of change of the maintenance of PSA and markers of angiogenesis and inflammation in blood serum at patients with prostate diseases. Material and Methods. 72 patients with the level of the general PSA more than 4 ju/ml were examined. The first group of patients with benign prostatic hyperplasia with histology conclusion and with benign prostatic hyperplasia and prostatic intraepithelial neoplasia of low degree included 29 patients, the second group consisted of 9 patients with prostatic intraepithelial neoplasia of high degree, the third group included 5 patients with the localized prostate cancer, the fourth group consisted of 25 patients with locally advanced prostate cancer, and the fifth group with 6 metastatic prostate cancer patients. Results. At patients with prostate diseases the rise of VEGF level in blood serum occurs with increase of the maintenance of PSA and develops at the precancer stage (the prostatic intraepithelial neoplasia of high degree) and against high concentration of biomarkers of inflammation. Determination of VEGF concentration in blood serum at patients with "a gray zone" of PSA may have clinical value at the personified maintaining of patients with prostate cancer at the stage of pre-biopsy diagnostics. Conclusion. The simultaneous increase of the VEGF content in blood serum and the general PSA at prostate cancer patients is one of characteristics of a progression of tumoral growth.

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Atorvastatin effect on values of endotheli-al condition and acute inflammation in patients on program hemodialysis

Year: 2013, volume 9 Issue: №1 Pages: 39-42
Heading: Clinical Pharmacology Article type: Original article
Authors: Barsuk A.L, Vozova А.М., Malinok Е.V., Kuzin V.B., Lovtsova L.V., Okrut I.E.
Organization: N. Novgorod State Medical Academy
Summary:

Objective: To study the effect of atorvastatin on the values of endothelial condition and acute inflammation in patients on program hemodialysis (PHD). Material and methods: The patients were divided into two groups: 28 PHD patients (main group) received atorvastatin, 20 mg once a day for 30 days, and 26 patients (control group) had PHD only. Endothelin 1-21 (ET) level and von Willebrand factor (vWF) activity were determined by enzyme immunoassay, nitric oxide (NO) levels — spectrophotometrically, C-reactive protein (CRP) — by immunoturbidimetric method, fibrinogen — by Clauss method. Results: After 30 days of observation, control patients were found to have NO and ET increase, as well as the reduced activity of vWF relative to initial data, while fibrinogen and CRP levels scarcely changed. The main group patients had similar changes of endothelial condition values, and their fibrinogen and CRP levels decreased. The correlation between the changes of ET and fibrinogen levels was recorded in the patients of the main group. Conclusion: 30-day administration of atorvastatin, 20 mg per day, lowers CRP and fibrinogen levels in PHD patients. It proves the applicability of statins in this group of patients in case of signs of inflammation.

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Nongaseous exchange functions of lungs in common severe viral-bacterial pneumonia genesis

Year: 2012, volume 8 Issue: №3 Pages: 738-744
Heading: Anaesthesiology and Reanimatology Article type: Review
Authors: Zeulina Е.Е., SadchikovD. V., Blokhina E.О.
Organization: Saratov State Medical University
Summary:

The review presents modern definitions, classifications and criteria of severity of common viral-bacterial pneumonia. The study of literature about the role of metabolic functions of the lungs in the genesis of severe common viral-bacterial pneumonia has allowed the formulations of anew period in the intensive care based on the study of noradrenalin inactivating functions of the lungs.

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The role of vascular disorders in the genesis and maintenance of infammation in the pathogenesis of rosacea

Year: 2012, volume 8 Issue: №2 Pages: 650-654
Heading: Skin Diseases Article type:
Authors: Slesarenko N.A., Leonova M.A., Zaharova N.B., Slesarenko N.S., Reznikova M.A.
Organization: Saratov State Medical University
Summary:

Aims. The study was aimed to identify relationships of immune disorders and angiogenesis in patients at different stages of rosacea. Materials and methods. We examined 110 patients with rosacea. The diagnosis was based on diagnostic criteria. We summarized the role of predictors in the development of rosacea. We investigated pro- and anti-infammatory cytokines, vascular endothelial growth actor (VEGF), fbroblast growth factor (FGF) for the detection of immune disorders and angiogenesis. Results. The immune response in patients with rosacea was of mixed Th-1 and Th-2 type which can be markers of chronic autoimmune infammation. Simultaneously with the change in cytokine profle we revealed activation of angiogenesis (high levels of VEGF, FGF).

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Urinary Cytokines Spectrum of Different Etiologic and Pathogenic Types at Children with Chronic Pyelonephritis

Year: 2011, volume 7 Issue: №4 Pages: 901-904
Heading: Pediatrics Article type: Original article
Authors: Merkodanova Yu.A., Utz I.A.
Organization: Saratov State Medical University
Summary:

Objective. We investigated the diagnostic role of urinary IL-1b, IL-6 and IL-8 in children with different etiologic and pathogenic variants of chronic pyelonephritis. Material and methods. 132 patients (92 girls and 40 boys) aged 1-17 with chronic pyelonephritis were examined: 18 patients with primary pyelonephritis (I group); 114 with secondary pyelonephritis (II group); 30 patients without kidney disease completed control group. Results. Our data showed increasing level of all mediators of inflammation, especially in acute stage of pyelonephritis and with 10-years anamnesis. We suggested the role of IL-6 in nephrosclerosis. Conclusion. The content of urinary IL-1b, IL-6 reflects the level of kidney inflammation, and IL-8 — the degree of inflammation. We conclude that the level of urinary IL-8 could be a new indicator for nephrosclerosis

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Integrated assessment of inflammatory process accompanying community-acquired pneumonia by means of radiometry

Year: 2011, volume 7 Issue: №4 Pages: 817-822
Heading: Internal Diseases Article type: Original article
Authors: Arzhnikov V.V., Lifshits V.В., Parfenyuk V.K., Terekhov I.V., Solodukhin K.A., Kondratjev A.S.
Organization: Saratov State Medical University, Saratov State Cardiosurgical Centre, Saratov Hospital MIA, Obninsk Institute of Atomic Energy, Department of Medicine
Summary:

The purpose of the article is to analyze possibility of active SHF radiometry use for inflammation monitoring in lower departments of lungs. Materials and methods: Analysis of humoral immunity (cytokine, complement and immunoglobu-lin status), angiogenesis, and modifications of extracellular matrix has been made by immune-enzyme method. Serum concentration of IL-1(3, IL-1Ra, TGF-(31, C3 and C5a components of complement system and lg M, lg G, VEGF-A, ММП-13 and TIMMP-2 has been estimated in the research. Intensity of radiation of lungs has been studied. Results: Synchronism of radiation dynamics with molecular markers has been determined. The period of changes of specified mediators is about 2 days. Critical time points of pathological process (3, 6, 8, 11 and 16 days) have been found out. Conclusions: It has been proved that SHF radiation of lungs may be applied in treatment of pneumonia for pathology monitoring

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Anemic syndrome in hospitalized patients with ischemic heart disease: inflammation marker or factor of pathogenesis?

Year: 2010, volume 6 Issue: №3 Pages: 596-600
Heading: Internal Diseases Article type: Original article
Authors: Suvorova S.A., Parkhonyuk Е.М., Shvarts Yu.G.
Organization: Ulyanovsk Central City Clinical Hospital, Saratov State Medical University
Summary:

The article presents the research results on the correlation between anemic syndrome and main risk factors in hospitalized patients with different forms of cardiovascular pathologies. This category of patients is characterized by more severe arterial hypertension and low level of total cholesterol in blood. It has been revealed that anemia in patients with CVD (cardiovascular diseases) is not only associated with unfavorable prognosis, but also becomes a marker of peculiarities in mechanism of disease development indicating the severity of inflammatory component

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