Saratov JOURNAL of Medical and Scientific Research

Nikulicheva V.I.

Bashkir State Medical University, Head of Department of Therapy and General Practice with Course of Geriatrics and Training of Interns of Therapeutic Profile, Professor, Doctor of Medical Science

Analysis of polymorph genetic variations of angiotensin converting enzyme, glutathione S-transferase in patients with cardiomyopathy

Year: 2012, volume 8 Issue: №2 Pages: 224-228
Heading: Internal Diseases Article type: Original article
Authors: Berg A.R., Chepurnaya A.N., Karimov D.О., Viktorova T.V., Nikulicheva V.I., Safuanova G.Sh.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

Tropicality. Cardiomyopathies (CMP) are diseases of unknown etiology. CMP are usually diagnosed in late stages of the disease. The search for diagnostic methods for CMP in the early stage is of great importance. The purpose is to determine the character of distribution of polymorph genetic variations rates of angiotensin converting enzyme (ACE), glutathione S- transferase (GSTM 1) among CMP patients and healthy subjects living in the Republic of Bashkortostan and to substantiate their value in CMP pathogenesis. Materials and methods. A total of 67 patients with CMP were included in the study. Out of them, 40 patients were diagnosed with ischemic cardiomyopathy (ICMP) and 27 patients — dilatation cardiomyopathy (DCMP). 110 healthy persons were enrolled in the control group. Results. In the group of patients with ICMP, the genotype DD (x2=4,81; p=0,029) occurred more frequently. In DCMP group, there was also an increase in frequency of DD genotype of polymorph genetic locus of ACE gene (%2=4,046; p=0,044). Conclusion. Genetic analysis of polymorph l/D locus of ACE gene in patients with ICMP and DCMP showed a decrease in occurrence rates of II, ID genotypes, allele I, as well as an increase in DD genotypes and allele D. This is associated with an increased risk for the development of these cardiovascular diseases

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Proinflammatory cytokine expression in patients with chronic obstructive pulmonary disease

Year: 2010, volume 6 Issue: №2 Pages: 314-317
Heading: Internal Diseases Article type: Original article
Authors: I.S. Abdurakhmanova, V.I. Nikulicheva, D.R. Vagapova, O.A. Enikeyev
Organization: Bashkir State Medical University of the Russian Health Care, Bashkir Republican Clinical Hospital
Summary:

The research goal was to investigate cytokine profile (IL-1p, 11_-1ра, IL-4, IL-6, IL-8, TNF-a and INF-у) in patients with chronic obstructive pulmonary disease (OOPD). The data of decreasing of anti-inflammatory IL-4 and increasing of proinflammatory cytokines in patients with OOPD were worked out. Inclusion of domestic immunomodulator of immunovenin in standard therapy of OOPD permitted to decrease concentration of proinflammatory cytokines and to increase the level of anti-inflammatory IL-4

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