Pediatrics

Objective. We investigated the diagnostic role of urinary IL-1b, IL-6 and IL-8 in children with different etiologic and pathogenic variants of chronic pyelonephritis. Material and methods. 132 patients (92 girls and 40 boys) aged 1-17 with chronic pyelonephritis were examined: 18 patients with primary pyelonephritis (I group); 114 with secondary pyelonephritis (II group); 30 patients without kidney disease completed control group. Results. Our data showed increasing level of all mediators of inflammation, especially in acute stage of pyelonephritis and with 10-years anamnesis. We suggested the role of IL-6 in nephrosclerosis. Conclusion. The content of urinary IL-1b, IL-6 reflects the level of kidney inflammation, and IL-8 — the degree of inflammation. We conclude that the level of urinary IL-8 could be a new indicator for nephrosclerosis

The study was undertaken to estimate the condition of mammary glands in adolescent girls. Material and methods. The study included 867 girls (aged 12-18). The questioning, total clinical examination, hormonal analysis and ultrasound examination were conducted. Results. The investigation shows that girls had breast dysmorphies (macromastia, hypoplasia, striae, asymmetry etc.). The dysplasia of mammary glands was diagnosed in 26% patients with menstrual disorders, thyroid diseases, mastalgia and obesity. High estradiol, LH, TSH, insulin, cortisole, testosterone and low progesterone level are the most specific hormonal markers of mastopathy in adolescent girls. Conclusion. Thyroid disorders, breast asymmetric form, mastalgia, obesity are the indicators for observation and examination of mammary glands

The article is concerned with observation of a child of 3,5 with hereditary Krista — Seimens — Turena syndrome. The clinical description of the syndrome and modern approaches to treatment have been analyzed

The aim of the work is to develop an algorithm of differentiated therapy in children with PNE. 234 children aged 5-15 years were studied. Results of treatment of children with primary nocturnal enuresis using the traditional therapeutic scheme and the algorithm of differential therapy based on identification of individual pathology were analyzed. The best clinical effect (recovery— in 73,1%, improvement— in 19,4% of cases) was obtained in children undergone the complex of recommended measures: psychological consultation, rational and family psychotherapy, medication correction, physical and physiotherapy, alarm-monitoring; the complex was used differentially, i.e. depending on the identified pathology. In conclusion the article stated that individual treatment program with the obligatory inclusion of alarm-control for child with PNE should be selected after performing the recommended set of diagnostic measures

Perinatal CNS damage is one of most actual problem of neonatology and its rate in structure of children invalidity is 60%. The purpose was to learn clinical efficiency of a course transcranial magnet therapy in complex with preparation Pantogam in rehabilitation of children with perinatal CNS damage. Materials. Clinical and neurophysiological studies were performed in 60 newborn children from 10 to 28 day of life. Results. The study showed that results of combined treatment (traveling impulse magnet field + Pantogam) was significantly (1,5 times) higher that efficacy of routine treatment only

The research work provides current data about prevalence of dysmorphia and mammary glands diseases in adolescent girls

Chronic hepatites for today remain the important problem with children among children»s infections not only in our country, but also all over the world. In clause the immune factors influencing on патогенез of a chronic virus hepatites В at children are considered. The purpose of our job was studying interrelation cytolysis and a structure of cytokines at children sick of a chronic virus hepatites В Century. Material, methods. We have carried out research a structure of cytokines at 87 children with CVH В in the age of from 7 months till 18 years. Clinical supervision and researches with application general-clinical, biochemical, tool, immunological the methods have been spent, allowing to receive the fullest and objective information on the observable children sick CVH. Results. If to compare parameters cytokines in replicative and integration phases at a chronic virus hepatites В at children it is necessary to note, that in replica-tive a phase the basic parameters are aggravated. The conclusion. It speaks that in replicative phase CVH disease more hard proceeds. The deviation of level FNO-a, IL-1, IL-10 cytokines in whey of blood of patients with CVH В from normal parameters is the indicator of gravity of inflammatory process

The risk of development and clinical course of somatic diseases have been analyzed in the research work. 111 adolescents suffering from connective tissue dysplasia have been under the study. It has been stated that the frequency of somatic diseases among adolescents with connective tissue dysplasia is higher than this frequency among adolescents without such disease. Phenotypic signs of connective tissue dysplasia have been revealed. They are responsible for the development of bronchial asthma and severe stomach ulcer

The aim of investigation is to study heart hemodynamics in teenagers with connective tissue dysplasia of heart (CTDH). 35 patients ages 12 to 15 years with CTDH have been observed: Group I (n=14) are the patients with mitral valve prolapse (MVP) without mitral regurgitation (MR) and myxomatous degeneration(MD) or isolated minor heart abnormalities (MHA), Group II (n=11)are patients with MVP and MR in combination with 1 or2 MHA, and Group III (n=10) are patients with MVP and mixoid degeneration (MD) in combination with 2 or more MHA. The control group consisted of 15 patients of the same age without MHA. All the children passed Doppler and echocardiography. According to the results significant changes of cardiohemodynamic indices in patients of Group I were not observed. The changes of size and volume indices of the left ventricle (LV), increase in wall thickness and diastolic dysfunction of the LV were observed in Group II. The significant changes of systolic function of left ventricular myocardium were observed in Group III. The study comes to the conclusion that teenagers with CTDH have definite changes of heart hemodynamics and functional state of left ventricular myocardium. These changes depend on mitral regurgitation, myxomatous degeneration and MHA combination

Changes in physical sizes and appearance of the child are manifestations of clinical, biochemical, neurologic and physiological changes which take place in childhood. The aim of the research is a comparative analysis of indicators of physical development of 11 437 newborns from Voronezh and Voronezh region over the last 25 years. Four basic anthropometrical signs in newborns- body mass, body length, head circumference, breast circumference - have been studied. Obstetric-gynecologic analysis of mothers anamneses have been carried. It was established that indicators of physical development differ in Voronezh and Voronezh region. Also the interrelation between physical development of newborns and anthropometrical indicators of women has been determined. The seasonal tendency of indicators of head circumference has been revealed