Saratov JOURNAL of Medical and Scientific Research

Saratov State Cardiosurgical Centre

Integrated assessment of inflammatory process accompanying community-acquired pneumonia by means of radiometry

Year: 2011, volume 7 Issue: №4 Pages: 817-822
Heading: Internal Diseases Article type: Original article
Authors: Arzhnikov V.V., Lifshits V.В., Parfenyuk V.K., Terekhov I.V., Solodukhin K.A., Kondratjev A.S.
Organization: Saratov State Medical University, Saratov State Cardiosurgical Centre, Saratov Hospital MIA, Obninsk Institute of Atomic Energy, Department of Medicine
Summary:

The purpose of the article is to analyze possibility of active SHF radiometry use for inflammation monitoring in lower departments of lungs. Materials and methods: Analysis of humoral immunity (cytokine, complement and immunoglobu-lin status), angiogenesis, and modifications of extracellular matrix has been made by immune-enzyme method. Serum concentration of IL-1(3, IL-1Ra, TGF-(31, C3 and C5a components of complement system and lg M, lg G, VEGF-A, ММП-13 and TIMMP-2 has been estimated in the research. Intensity of radiation of lungs has been studied. Results: Synchronism of radiation dynamics with molecular markers has been determined. The period of changes of specified mediators is about 2 days. Critical time points of pathological process (3, 6, 8, 11 and 16 days) have been found out. Conclusions: It has been proved that SHF radiation of lungs may be applied in treatment of pneumonia for pathology monitoring

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The differential approach to estimation of renal damage in the patients with nephrolithiasis by means of noninva-sive markers

Year: 2010, volume 6 Issue: №3 Pages: 708-715
Heading: Urology Article type: Original article
Authors: Rossolovsky A.N., Glybochko P.M., Popkov V.M., Polozov A.B., Ponukalin A.N., Zakharova N.B., Berezinetz O.L., Blumberg B.I.
Organization: Saratov State Medical University, Saratov State Cardiosurgical Centre, First Moscow State Medical University n.a. I.M. Sechenov
Summary:

The aim of this study was the estimation of clinical importance markers of renal damage at surgical treatment of nephrolithiasis. We studied results of operations in 110 patients with nephrolithiasis. The study presents new candidates for biochemical markers of acute kidney injury and renal interstitial fibrosis, with potentially high sensitivity and specificity. In this study were measured the concentrations of these biomarkers in urine. We suggested, that increased concentrations molecular mediators of renal damage (L2, IL-18) and interstitial fibrosis (MCP-1, TGFp, IGF1) in the patients with nephrophibrosis and strongetubulointerstitial injury, saved long-time period after operation, has been shown of progression chronic kidney disease

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State of renal hemodynamics and nephrofibrosis parameters in patients with nephrolithiasis applying angiotensin converting enzyme inhibitors

Year: 2010, volume 6 Issue: №1 Pages: 170-173
Heading: Urology Article type: Original article
Authors: P.V. Glybochko, A.A. Svistunov, A.N. Rossolovsky, O.L. Berezinetz, N.B. Zakharova, A.P. Abramova
Organization: Saratov State Medical University, Saratov State Cardiosurgical Centre
Summary:

The aim of the study is to evaluate the influence of angiotensin converting enzyme (ACE) inhibitors of quinapril on the condition of renal hemodynamics, changes of profibrotic cytokines level and transforming growth factor at patients with nephrolithiasis undergone various kinds of surgery. Patients were divided into 2 groups initially and in 1 month after surgery. Concentrations of IL-6, TGFp and МСР-1 were determined in blood serum. Assessment of renal blood flow state by Doppler ultrasonography was performed in the same terms. As a result of quinapril treatment the decrease of МСР-1, TGFp and IL-6 was marked in comparison with the group which did not receive nephroprotective therapy. The analysis of Doppler ultrasonography data showed authentic improvement of renal blood flow in 1 month after surgery. The most informative parameter proved to be the resistance index that indicated the decrease of vascular resistance after surgical treatment in condition of quinapril therapy

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