Saratov JOURNAL of Medical and Scientific Research

Popkov V.M.

Saratov State Medical University n.a. V.I. Razumovsky, Department of Urology, Assistant Professor, Candidate of Medical Science

Prognostic factors in the estimation of HIFU treatment efficiency in patients with localized prostate cancer

Year: 2013, volume 9 Issue: №1 Pages: 116-121
Heading: Urology Article type: Original article
Authors: Popkov V.M., Fomkin R.N., Blyumberg B.I.
Organization: Saratov State Medical University
Summary:

Research objective: To study the role of prognostic factors in the estimation of risk development of recurrent prostate cancer after treatment by high-intensive focused ultrasound (HIUF). Objects and Research Methods: The research has included 102 patients with morphologically revealed localized prostate cancer by biopsy. They have been on treatment in Clinic of Urology of the Saratov Clinical Hospital n.a. S. R. Mirotvortsev. 102 sessions of initial operative treatment of prostate cancer by the method of HIFU have been performed. The general group of patients (n=102) has been subdivided by the method of casual distribution into two samples: group of patients with absent recurrent tumor and group of patients with the revealed recurrent tumor, by morphological research of biopsy material of residual prostate tissue after HIFU. The computer program has been used to study the signs of outcome of patients with prostate cancer. Results: Risk of development of recurrent prostate cancer has grown with the PSA level raise and its density. The index of positive biopsy columns

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Postoperative monitoring of prostate-specific antigen (PSA) after treatment with high-intensive focused ultrasound (HIFU

Year: 2012, volume 8 Issue: №4 Pages: 1001-1007
Heading: Urology Article type: Original article
Authors: Popkov V.M., Fomkin R.N., Blyumberg B.I.
Organization: Saratov State Medical University
Summary:

Research objective: to estimate efficiency of treatment of prostate cancer using high-intensive focused ultrasound on the basis of laboratory analysis of postoperative level prostate-specific antigen (PSA). Objects of research. Objects of research consisted of 110 patients treated in urological clinic of Hospital n.a. S. R. Mirotvortsev (Saratov State Medical University) during the period February, 2009 — March, 2012. Patients took 110 sessions of primary operative treatment of prostate cancer by HIFU therapy method. Technique and research methods. Concentration of PSA in blood changed in all patients every 1,5 month within 6 months after operation, irrespective of its kind (including after repeated HIFU), further — after every 3 month till one year, and later on after 6 months. We were guided by references of the International Consensus, which considers PSA level more than 0,5 ng/ml in blood after 3 months of treatment to be unsatisfactory result. We also headed for PSA level before treatment and oncological risk degree. Results. Median nadir formed 0,5 ng/ml PSA by 3 months after treatment. Patients demonstrated different indicators of PSA dynamics depending on oncological risk, stage and hormonal therapy management. Patients with low oncological risk had initially lower PSA concentration, further PSA concentration reached nadir level faster. At patients with widespread forms of prostate cancer accurate dependence of PSA concentration according to prevalence of process was traced. Time of PSA nadir amount did not differ and was marked as 12-14 weeks on average. At patients received hormonal therapy, lower value of PSA nadir was marked. The conclusion. Monitoring of PSA concentration (PSA nadir by 3 months, dynamics of PSA concentration change) is of great importance in early revealing of relapse after prostate HIFU therapy. High level of PSA nadir and PSA growth according to time period are important prognostic factors.

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High intensity focused ultrasound (HIFU) as the alternative method of treatment of oncourological diseases

Year: 2012, volume 8 Issue: №4 Pages: 989-995
Heading: Urology Article type: Review
Authors: Popkov V.M., Fomkin R.N., Blyumberg B.I.
Organization: Saratov State Medical University
Summary:

Increasing interest devoted to technology of high intensity focused ultrasound (high-intensity focused ultrasound, HIFU), basically, is explained by a wide spectrum of potential fields of application at minimum invasiveness of the given method. In oncourology HIFU is applied in prostate and kidney cancer. In case of tumors of renal parenchyma the given technique is being clinically tested, while HIFU is currently used in the practice of European oncourologists in treatment of prostate cancer. The majority of the references describing the results of HIFU application in prostate cancer is based on data of a number of clinical observations. It has been proved that HIFU is a possible method of treatment of highly — and moderate-differentiated tumors, and local relapses after remote radial therapy.

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Radiological methods for diagnostics of kidney cancer

Year: 2012, volume 8 Issue: №3 Pages: 834-841
Heading: Urology Article type: Review
Authors: Popkov V.M., Nikolsky Yu.E., Chekhonatskaya M.L, Zakharova N.B., Ponukalin A.N., Zuev V.V.
Organization: Saratov State Medical University
Summary:

It is stated that kidney cancer takes one of the leading places in the cancer incidence. Particular attention should be paid to renal cell carcinoma. By means of modern methods of volume visualization it is possible to diagnose small renal tumors, to prognose the process of tumor development and to save organs by surgical intervention.

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Low-frequency magnetic field effect on solubility of oxalate type human organominerals in water in vitro

Year: 2012, volume 8 Issue: №3 Pages: 831-834
Heading: Urology Article type: Original article
Authors: PopkovV.M., Usanov D.A., Usanov A. D., Rebrov V.G., Verkhov D.G., Bulanov V.M.
Organization: Saratov state university, Saratov State Medical University, Saratov Laboratory of Forensic Examination
Summary:

The research goal is to determine low-frequency AMF effect on dissolution of urinary stone material in vitro in water with human urinary stones (oxalate type). Materials and Methods. The structural changes in aqueous solutions may occur when exposed to low-frequency alternating magnetic fields (AMF). It depends on chemical composition of the solutions under the study. Results. Organic components (63.1 %), leading to the density decrease of the solution, urea (18.8%), leading to its increase, and oxalic acid (19.7%) have been determined in stone composition. The decrease of transmittance T (%) by the time of oxalate dissolution has indicated increase in concentration of dissolved sample. The sample has been exposed to AMF of 2-9 Hz on the background of the control sample. The growth of this dependence with AMF increasing of 11-22 Hz has established less concentration of dissolved sample in the test solution than in the control one. Conclusion. The main task has been to determine the influence of AMF of 2-22 Hz on solubility of urinary stones placed in water for an hour. The article is to conclude that maximal solubility of oxalate mineral sample by AMF of 2-22 Hz has been reached. It is 14% more than in the control solution. The effectiveness of AMF influence on solubility of organomineral decreases with frequency increasing. It has been confirmed by photometric and areometric measurements.

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Road one hundred years long: history of neurology development in Saratov

Year: 2012, volume 8 Issue: №2 Pages: 357-364
Heading: Neurology Article type: Review
Authors: Popkov V.M., Protopopov A.A., Alenkina E.V., Sholomov 1.1., Voskresenskaya O.N., Kolokolov О.V.
Organization: Saratov State Medical University, First Moscow State Medical University n.a. I.M. Sechenov
Summary:

The article presents information about the history of neurology in Saratov.

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Magnetic resonance diffusion-weighted whole-body imaging (DWIBS) in bladder cancer diagnostics

Year: 2011, volume 7 Issue: №4 Pages: 941-946
Heading: Urology Article type: Original article
Authors: Popkov V.M., Chekhonatskaya M.L., Zuev V.V., Ponukalin A.N., Nikolsky Y.E.
Organization: Saratov State Medical University
Summary:

The purpose of the article is to identify the most characteristic and significant changes in indicators in patients with bladder cancer during diffusion-weighted whole-body imaging (DWIBS). Materials: From September 2009 till 2011 98 patients have been examined (61 (62,24%) with morphologically verified bladder cancer and 37 (37,76%) with cystitis. Results: The study has revealed that the sensitivity of DWIBS-study in detecting bladder cancer is 98,36%, specificity of 10,81 %, the efficacy of 65,38%. Conclusions: DWIBS is an informative noninvasive method for screening diagnostics of bladder cancer, to identify suspicious areas on regional, and distant metastases

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Innovation and development prospects of pre-university education of Saratov State Medical University

Year: 2011, volume 7 Issue: №3 Pages: 727-730
Heading: Pedagogics and Education Article type: Original article
Authors: Popkov V.M., Protopopov A. A., Fedorova L.M., Naumova E.V.
Organization: Saratov State Medical University
Summary:

The article considers innovative methods used in the pre-university education at Saratov State Medical University and directed to the modernization of educational program. It points out that competence-based approach includes the following components — problem teaching and adaptive system, heuristic teaching, personal approach to teaching, computerization, distant education technologies and integration-module technology

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Opportunities of radiological methods for examination in diagnostics of urinary bladder cancer

Year: 2011, volume 7 Issue: №1 Pages: 148-151
Heading: Urology Article type: Review
Authors: Glybochko P.V., Zuev V.V., Popkov V.M., Chekhonatskaya M.L, Ponukalin A.N.
Organization: Saratov State Medical University, First Moscow State Medical University n.a. I.M. Sechenov
Summary:

The research goal is the comparative analysis of Russian and foreign studies concerned the possibility of radiological methods of diagnostics of cancer of urinary bladder. The problem of early diagnostics of initial tumor and tumor recurrence, determination of stages of bladder cancer, its prognosis and outcome remains an actual one

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Academic Aleksandr Nikolaevich Bakulev (Dedicated to the 120-th Anniversary of His Birth)

Year: 2010, volume 6 Issue: №4 Pages: 870-874
Heading: Scientific schools Article type:
Authors: Popkov V.M., Zavyalov A.I.
Organization: Saratov State Medical University
Summary:

The article presents biographic information about academician A.N. Bakulev, his scientific and practical contribution to the development of cardiovascular and thoracic surgery, neurosurgery and creation of scientific surgery school in the USSR

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