Samara State Medical University

The article discusses the surgical treatment of ingrown nail in patients with recurrent disease. The advantages of a new method of operation have been explained in the article. It gives a detailed description of the operation. The clinical and additional methods of research have confirmed the fact that a new operation reduces the wound healing period and the number of ingrown nail recurrences

Postural abnormalities are clinical syndromes that lead to disability in patients with Parkinson's disease. The aim of the study is to investigate the characteristics of postural control in different clinical forms of Parkinson's disease using a computer stabilometer examination. Materials and Methods: Clinical and neurophysiological analysis has been performed in 148 patients with Parkinson's disease who have been divided into groups with akineticorigid, shaking-rigid and shaking forms of the disease. All patients have experienced static stabilometer examination with medical-diagnostic complex «MBN-Biomechanics» (Scientific-Medical Firm MBN, Moscow). Results of the research have proved a significant decrease of compensatory abilities of balance maintenance and the basic standing without dependence on the clinical form of disease. It has been noted that a number of indices have been increased. It has been revealed, that the tremor at rest has influenced significantly the values of such indices. Dissociation between the clinical severity of postural instability and stabilometer indicators reflecting the state of the vertical balance of the body has been revealed. The study has confirmed the importance of the differentiated approach to stabilometer analysis in patients with different forms of Parkinson's disease. Conclusion: Computer stabilometry makes possible the detection of disturbances in postural functions and estimation of their condition in dynamics

The purpose of the investigation is to evaluate the long term results of surgical treatment in children with esotropia, operated according to new scheme of muscle procedures. Materials. The retrospective analysis of surgical treatment in 50 children with esotropia was made. The new scheme of muscle recession / resection was used. Results. The duration of monitoring was 1-5 years. More then half of all patients has ortotropia, even in cases with 25° primary deviation angle. Almost 40% of patients has increasing of visual acuity of amblyopic eye and binocular functions. Conclusion. The new scheme of muscle recession / resection allows to receive ortotropia after surgical treatment in large esotropia and avoid the reoperations. Using of the new scheme of strabismus surgery don't increase the quantity of secondary exodeviation

Methods: to optimize treatment of patients with complicated forms of chronic venous insufficiency of our method was applied systems analysis, proposed by Th. Saaty (1993), and was called the «method of analysis of hierarchies». Results: the results indicate a direct relationship to the choice of methods for the treatment of patients with complicated forms of chronic venous insufficiency of the influence of individual actors and the goals of each. Conclusion: applying the analytic hierarchy process in selecting a method of treatment in patients with complicated forms of chronic venous insufficiency of the lower extremities can improve the quality of life of patients and reduce the frequency of disability, reduce the rate of loss of ability to self-service, as well as reduce the costs of treating both the patient and medical institution

The article provides data on prevalence and smoking status assessment among students of senior courses of medical university, the purpose of the study was to evaluate smoking prevalence and status in students of medical university in order to develop recommendations on healthy life style promotion. 58 senior students, 18 men and 40 women, were under study. Screening survey, spirometry, Fagerstrem test, questionnaires on motivation to stop smoking and test to reveal chronic bronchitis were held. Smoking was highly spread among the students of therapeutic faculty. The longest period of smoking was detected among male students of medico-prophylactic, and the highest intensity was revealed among female students of therapeutic faculty. Nicotine addiction in all groups was described as «very weak» and the highest degree was marked among men of medico-prophylactic faculty in particularly. Unwillingness of students (lack of motivation) to stop smoking was determined

Chronic hepatites for today remain the important problem with children among children»s infections not only in our country, but also all over the world. In clause the immune factors influencing on патогенез of a chronic virus hepatites В at children are considered. The purpose of our job was studying interrelation cytolysis and a structure of cytokines at children sick of a chronic virus hepatites В Century. Material, methods. We have carried out research a structure of cytokines at 87 children with CVH В in the age of from 7 months till 18 years. Clinical supervision and researches with application general-clinical, biochemical, tool, immunological the methods have been spent, allowing to receive the fullest and objective information on the observable children sick CVH. Results. If to compare parameters cytokines in replicative and integration phases at a chronic virus hepatites В at children it is necessary to note, that in replica-tive a phase the basic parameters are aggravated. The conclusion. It speaks that in replicative phase CVH disease more hard proceeds. The deviation of level FNO-a, IL-1, IL-10 cytokines in whey of blood of patients with CVH В from normal parameters is the indicator of gravity of inflammatory process

In article one of oncology problems — a skin melanoma is surveyed. The theme urgency proves to be true that annually the case rate of patients with an oncologic pathology is constantly enlarged. One of oncology problems still has a skin melanoma. The work purpose is studying of a case rate by a skin melanoma in large industrial area on an example of the Samara region over the last 10 years. In article one of oncology problems — a skin melanoma is surveyed. For the task in view decision following materials and methods were used: primary registration documentation for 11 years (1999-2009) About for the first time taped disease a skin melanoma, annual reports of the Samara regional clinical oncologic dispensary, annual statistical reports of the State statistical committee, bureau MSE annual reports. At processing and the forecast of results of research following statistical methods — an extrapolation method, model of linear regress were used. Reliability of the taped pattern of dynamics was defined by means of an error of regress with the subsequent definition t and p. The received results testify to growth of a case rate of all population of the Samara region at the expense of the senior age groups. According to the analysis the invalid population is more often is ill. Conclusions are drawn on appreciable influence on occurrence of this pathology occurring in an organism involutes processes, necessity of carrying out of sanitary-educational work, carrying out of additional profound inspection among the population with high level of a case rate

The research goal is to study morbidity dynamics for the period of 15 years and to determine clinical signs that accompany quinsy syndrome (diphtheria, infectious mononucleosis, scarlet fever, quinsy). Retrospective study analysis of annual reports and case-histories was carried out. 323 cases of infectious diseases accompanied by quinsy syndrome were examined. Clinical and epidemic signs of diseases were determined during the period of morbidity raise. The current clinical course of diseases was characterized in detail. The significant percentage of renal complications in case of pharyngonasal cavity lesion was shown

Objective. The research goal is to estimate prognostic and diagnostic possibilities of markers of endothelial dysfunction, deciduation, apoptosis and cellular proliferation concerning realization of placental insufficiency. Material. 154 women of high risk group of severe placental insufficiency development have been examined in dynamics of the second and third trimesters of pregnancy. 30 healthy pregnant women have made the control group. Research methods are clinical, immunological, instrumental. Results. It is established that prognosis and early diagnostics for severe placental insufficiency can be carried out with application of monitoring of the maintenance of endothelial dysfunction markers, placental fibers of a mother placenta membrane, apoptosis and cellular proliferation in blood. In the second trimester of pregnancy prognostically significant criteria have included an increase of an index of cytotoxicity of antien-dothelial antibodies, the general IgE, lymphocytes, expressing Fas/APO-1/CD 95-receptor, TNFb and decrease of FGP. Conclusion. Therefore the forms of realization and severity level of placental insufficiency have been caused by the beginning and degree of damages in adaptation of endothelial systems, activation of the immunopathological reactions in the placenta manifested by trophoblastoma programmed cellular destruction of lymphocytes

Complex examination of 296 patients with obliterating atherosclerosis of lower extremities was carried out. Prog-nostically significant clinical, hemodynamic, hemostatic, immunological characteristics, markers of endothelial dysfunction and changes in lipid profile in patients were studied. Pathogenetic system of disease prognosis was worked out as a result of multifactor analysis where the index of course of disease was accounted. When the index was lower than + 13, obliterating atherosclerosis was not considered as progressive. Progressive atherosclerosis was determined with the index over the point +13