Saratov JOURNAL of Medical and Scientific Research

Samara State Medical University

Analysis of the coagulates intensity in laser treatment of diabetic macular edema in a Navilas robotic laser system

Year: 2017, volume 13 Issue: №2 Pages: 375-378
Heading: Ophtalmology Article type: Original article
Authors: Zamytskiy Е.А., Zolotarev A.V., Karlova E.V., Zamytskiy P.A.
Organization: Samara Regional Clinical Ophthalmological Hospital n.a. T. I. Broshevskiy, Samara State Medical University
Summary:

The aim ofthisworkwasto analyze the intensity of the laser coagulates in the treatment of diabetic macular edema conducted in navigation mode on robotic laser system Navilas. Material and Methods. Retrospective analysis of outpatient cards and photographs of the fundus 20 patients (28 eyes) had been done. The patients had type II diabetes mellitus. We performed laser treatment of diabetic macular edema. There were evaluated 4260 coagulates, of which 0 degree 2166 (50.85%), I degree —525 (12.32%), II degree —747 (15.74%), III degree—498 (11.96%), grade IV — 324 (7.6 per cent). Result. The thickness of the retina before treatment in the area of edema was made 339.72±45.3 urn, and after treatment 346±70 urn, student's t-test 0.7124, a difference of 6.5±57.4. Visual acuity before treatment 0.532±0.3, after— 0.521±0.3mm, student's t-test 0,889. Conclusion. The facts obtained in the analysis suggests that the algorithm of selection of power and the way it adjustments in the course of treatment are the weak point of this technique. Development of new methods, giving the possibility to adjust the power depending on the height of the swelling region of the retina, thereby gaining coagulates strictly necessary for the specific case of intensity, will enable to increase the efficiency and safety of laser treatment.

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Early detection of cognitive impairment in patients with multiple sclerosis

Year: 2017, volume 13 Issue: №1 Pages: 164-168
Heading: Neurology Article type: Original article
Authors: Poverennova I.E., Romanova T.V., Zakharov A.V., Khivintseva E.V.
Organization: Samara State Medical University
Summary:

The aim of the study was to examine cognitive impairment in patients with multiple sclerosis with an emphasis on the speed and efficiency of information processing. It was supposed to reveal the patterns of these disorders depending on the duration and severity of the disease. Material and methods. The study included 50 patients with established diagnosis of clinically significant multiple sclerosis, a relapsing-remitting course. The EDSS score was evaluated. Cognitive functions were assessed using SDMT and PASAT-3 tests. All patients underwent a study of cognitive evoked potential. All examined patients were divided into 2 groups depending on the duration of the disease. Results. Cognitive screening tests PASSAT and SDMT showed no correlation with the duration of the disease severity and cannot serve as a tool for screening early signs of cognitive impairment in young patients with multiple sclerosis. A significant increase in latency of the P300 potential was obtained with increasing duration and severity of the disease, which correlates with the severity of cognitive dysfunction. Conclusion. This study is the initial step in the search for a tool for screening early manifestations of cognitive impairment in patients with multiple sclerosis. In the future it is planned to expand the research with the modernization of its design.

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The analysis of the clinical and tool parameters characterizing a cardiomyopathyat various forms of the progressing muscular dystrophies

Year: 2017, volume 13 Issue: №1 Pages: 160-164
Heading: Neurology Article type: Original article
Authors: Poverennova I.E., Zakharov A.V., Chernikova V.V.
Organization: Samara State Medical University, Samara Regional Clinical Hospital n.a. V. D. Seredavin
Summary:

Purpose: studying of clinical and tool characteristics of cardiomyopathies at various forms of the progressing muscular dystrophies. Material and methods. There had been 103 patients with hereditary forms of the progressing muscular dystrophies examined, among which 35 persons were with Duchenne muscular dystrophy, 28 with an atrophic myo-tonia, and 40 with a limb girdle dystrophy is conducted. Assessment of clinical and tool features of cardiomyopathies at these types of the hereditary progressing muscular dystrophies had been carried out. Results. In the group of patients with diffusion damage of a myocardium in the form of dystrophic violations had been revealed. Existence of a negative tooth of T in some assignments and lengthenings of an interval of QT is noted. With a dystrophic myotonia violation of a warm rhythm occurred at patients by 87 times more often than in the group of comparison. Violation of a rhythm of heart in group of patients with a limb girdle dystrophy came to light 91 times more often in reference to the group of comparison. Conclusion. Violations in a cardiovascular system at Duchenne muscular dystrophy are preferentially diffusion changes in a myocardium. At a dystrophic myotonia and a limb girdle dystrophy cardial violations concern mainly excitability and the conductivity of heart which are the main reason of developing of this disease at these patients.

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Innovation in diagnostics and treatment of epilepsy

Year: 2017, volume 13 Issue: №1 Pages: 143-147
Heading: Neurology Article type: Review
Authors: Kalinin V.A., Poverennova I.E., Yakunina A.V., Beketova E.M.
Organization: Samara State Medical University, Municipal Hospital No. 1 n.a. N. I. Pirogov, Samara
Summary:

The aim of the review is try to systematize the innovative achievements of modern epileptology and indicate the levels of diagnosis and treatment of epilepsy that are not sufficiently developed, from our point of view. Applied to epileptology, the innovation process is realized at all levels. In principle, you can divide the entire process into a diagnostic and treatment level. Promising in the diagnosis of epilepsy should be considered the analysis of age characteristics, new methods of EEG analysis and evoked potentials, innovative methods of functional neuroimaging, genetic testing. New anticonvulsants with the original mechanism of action allow to overcome pharmaco-resistance of epilepsy in a number of observations. In rare cases it is necessary to use minimally invasive surgical methods of treatment.

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Improvement of technology of clasp dentures manufacture

Year: 2016, volume 12 Issue: №4 Pages: 589-592
Heading: Stomatology Article type: Original article
Authors: Komlev S.S.
Organization: Samara State Medical University
Summary:

The aim of the article is to improve the technology of clasp dentures manufacture. Material and Methods. Orthopaedic treatment of 27 patients was conducted using advanced technology of manufacturing clasp dentures at the Department of Prosthetic Dentistry at Samara State Medical University. Results. Conducting the orthopaedic treatment a method of obtaining an impression in prosthetics on implants and teeth, a method of manufacturing clasp denture with locking fasteners and a method of manufacturing a clasp denture with a questionable prognosis of bearing tooth were used. Conclusion. Using the advanced technology of manufacturing clasp denture has solved the problem with unreliable periodontal tissues, loss of a removable part of clasp denture and allowed to improve the quality of obtaining impression from bearing teeth.

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Clinical and instrumental risk factors for epileptic seizures in patients after traumatic brain injury

Year: 2016, volume 12 Issue: №3 Pages: 366-370
Heading: Neurology Article type: Original article
Authors: Zakharov A.V., Poverennova I.E., Kurov M.V., Khivintseva E.M.
Organization: Samara State Medical University
Summary:

The aim: analysis of factors influencing the risks of posttraumatic epilepsy (РТЕ). Materials and Methods. The study involved 71 patients with traumatic brain injury of moderate and severe with emerging after her epileptic seizures. Among the subjects was 56 (78.9%) males and 15 (21.1%) females. The average age of the subjects was 65.6±10,3 years. The control group was 25 (71.4%) male patients and 10 (28.6%) females. The average age of the patients was 54.4.±9.3 years. Analysis of factors influencing the risks of РТЕ use nonparametric Spearman correlation and multivari-ate analysis of variance. Results. Among the many factors to be statistically significant risk factors for РТЕ was alcohol intoxication at the time of trauma 27 (38,0%), relative to the control group 2 (5.7%) p

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Early and late myasthenia gravis

Year: 2016, volume 12 Issue: №2 Pages: 287-292
Heading: Neurology Article type: Original article
Authors: Romanova T.V., Poverennova I.E.
Organization: Samara State Medical University
Summary:

The aim: the hypothesis testing of the existence of two different groups of patients with different age at disease onset in a large population of patients with methods multidimensional constellation. Materials and Methods. Analysis of 444 patients enrolled in the register of patients with myasthenia in the Samara region. The duration of disease was more than 1 year. Statistical results of the study was carried out using a multi-dimensional grouping by cluster analysis Checking the quality of the classification was carried out using discriminant analysis. Results. Transient age between the two groups was defined as 40 years. The most important criteria of distinction patients group was sex of the patient and the presence of thymic hyperplasia. Conclusion. These clinical and immunologic patterns of early-onset and late-onset myasthenia gravis can serve as a basis of formation flow forecast model of myasthenia gravis and to create an algorithm of patient management.

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Identifying non-motor symptoms in Parkinson's disease and their connection with motor symptoms

Year: 2016, volume 12 Issue: №2 Pages: 281-285
Heading: Neurology Article type: Original article
Authors: Poverennova I.E., Kalinin V.A., Muchina S.A.
Organization: Samara State Medical University, Saratov State Medical University
Summary:

The aim: the identification of patterns of formation and course of non-motor fluctuations in this disease and theirs connection with motor symptoms. Materials and Method, for realization of a research objective at 54 patients with Parkinson's disease were used special diagnostic methods, for assess the credibility — methods of mathematical statistics. Results. It was established, that with increasing duration of disease degree of severity of non-motor symptoms grow up; it is noted a direct correlation between results in scales for exploration Parkinson's disease. Conclusion. In the treatment of patients with Parkinson's disease necessary consider the non-motor fluctuations. There are a lot of scales for exploration this disturbance, but they are subjective and for their conduction need a lot of time. So, question of creation new, objective and quick in carrying out scales are open.

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The issue on the use of information and communication technologies in the work of the territorial Roszdravnadzor

Year: 2015, volume 11 Issue: №2 Pages: 93-97
Heading: Health Service Organization Article type: Original article
Authors: Antimonov A.V., Sergeev V.V., Tsymbal D.E.
Organization: Saratov Territorial Roszdravnadzor, Samara Territorial Roszdravnadzor, Samara State Medical University
Summary:

Objective: to identify ways to use ICT in some areas of work of the territorial authority of Roszdravnadzor. Materials and Methods. We used a questionnaire survey of 50 employees of territorial bodies of Roszdravnadzor, 50 employees of the licensing bodies of the three subjects of the Russian Federation (the Republic of Tatarstan, Samara and Saratov region), 50 license applicants in the territory of the Samara region (a total of 150 respondents). For statistical processing of the results we used the criterion ("Chi-square") K. Pearson. Results. The analysis of the survey results reliably indicates a broad support for the subjects of licensing relations the introduction of modern ICT in the work of the relevant public authority. Conclusion. The study results of the views of the staff of the licensing authorities and applicants of licenses for medical activities on introduction of modern information and communication technologies in the work of the licensing authority have been presented. As possible methods it has been suggested the use of special (special programmes) and general (content site) groups.

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Differential diagnostics of different nosological forms of the temporomandibular joint pain dysfunction syndrome

Year: 2014, volume 10 Issue: №3 Pages: 432-435
Heading: Stomatology Article type: Original article
Authors: Kameneva L.A., Potapov V.P., Tlustenko V.P., Potapov I.V., Maltceva A.V., Hatuntseva T.N.
Organization: Samara State Medical University
Summary:

Research objective: to carry out differential diagnostics of various nosological forms of a temporal and temporomandibular joint pain dysfunction syndrome. Material and methods. On clinical base of orthopedic odontology chair of SamSMU inspection of 244 patients with temporomandibular joint pain dysfunction syndrome was performed. Diagnostics was carried out according to the special card of inspection which was developed on orthopedic odontology chair of SamSMU and included subjective, objective and special methods of research. As a result of research it is taped: 71 — an occlusal-articulation dysfunctional syndrome, 44 — a neuromuscular dysfunctional syndrome, 76 patients have a hardly set dislocation of intra joint disk and 53 — a habitual dislocation and a subluxation of a temporomandibular joint. We used Yu.A. Petrosov's classification as it displays most precisely the processes happening at pathology of the intra joint relations. Conclusion: On the basis of the obtained data the table of differential diagnostics of various nosological forms of temporomandibular joint pain dysfunction syndrome has been made.

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