Saratov JOURNAL of Medical and Scientific Research

chronic pancreatitis

Lipid peroxidation and glutathione antiox-idant protection in patients with an exacerbation of chronic pancreatitis

Year: 2013, volume 9 Issue: №2 Pages: 259-262
Heading: Internal Diseases Article type: Original article
Authors: Merinova N.I., Kozlova N.М., Kolesnichenko L.S., Suslova A.I., Leonova Z.A.
Organization: Irkutsk State Medical University
Summary:

Aim: to assess the levels of lipid peroxidation (LPO) products of malondialdehyde (MDA) and glutathione system in patients with the exacerbation of chronic pancreatitis (CP). Material and Methods: 80 patients with exacerbation of CP and 23 controls have been investigated. The level of reduced glutathione (GSH) and activity of enzymes of glutathione reductase (GR), glutathione transferase (GT), glutathione peroxidase (GP) have been determined in plasma and erythrocytes, while the MDA has been studied in plasma. Results: The MDA levels in plasma were higher in CP patients as against the values of the controls. The MDA level correlated positively with intensity of pain. Increased GSH concentration and activity of GT were revealed in plasma. In the erythrocytes reduction in GP activity and GSH concentration were determined. Conclusion: In the exacerbation of chronic pancreatitis lipid peroxidation and reduced antioxidant protection have been activated.

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Comparative assessment of efficacy of different methods of treatment of pancreatogenic diabetes mellitus in alcoholic and biliary forms of chronic pancreatitis

Year: 2012, volume 8 Issue: №3 Pages: 859-862
Heading: Endocrinology Article type: Original article
Authors: Kunitsyna М.А., Kashkina E.I.
Organization: Saratov State Medical University
Summary:

Aim: the study was devoted to the analysis of efficacy of different methods of treatment of pancreatogenic diabetes mellitus (DM) in alcoholic and biliary forms of chronic pancreatitis (CP). Material and methods. We have observed 86 patients with CP and first diagnosed DM. The assessment of carbohydrate metabolism compensation via HbA1 с level was done using analyzer IMX «Abbot» (USA). Results. At the 1st step of DM treatment we recommended the lifestyle modification and usage of creon 30-60.000 units daily. At the 2d step of treatment if necessary we added glyclazide. Conclusion. We have detected that irrespective of duration of alcoholic form of CP in case of subsequent DM development the lifestyle modification together with replacement ferment therapy in 90% of cases were non-effective. In the result of the research it was established, in case of 3 and more relapses per year in alcoholic form of CPthe probability of achievement of target HbA1 с level in complex with lifestyle changes and replacement ferment therapy was twice low, in connection with that fact the indication of oral anti-diabetic agents became necessary.

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Features of clinical course and quality of life in patients with chronic pancreatitis and diabetes mellitus

Year: 2011, volume 7 Issue: №1 Pages: 087-091
Heading: Internal Diseases Article type: Original article
Authors: Kunitsyna М.А., Kashkina E.I.
Organization: Saratov State Medical University
Summary:

Clinical and life quality features of 183 patients with chronic pancreatitis and diabetes mellitus were studied. We have found that the incidence of exacerbations increased by 36,7% after the appearance of diabetes mellitus, the number of days of loss of ability to work increased by 27,8%, the quality of life decreased

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MEMBRANOUS INTESTINAL DIGESTION CHARACTERISTICS IN PATIENTS WITH CHRONIC PANCREATITIS

Year: 2009, volume 5 Issue: №1 Pages: 72-75
Heading: Internal Diseases Article type: Original article
Authors: О.А. Stгокоva, E.J. Eremina
Organization: Mordovian State University
Summary:

The study of enzymes activity of membranous intestinal digestion has been carried out. The condition of ultrastructure of mucous membrane of a small bowel in patients with chronic pancreatitis taking into account duration of disease is presented. It is shown, that signs of lesion of a small bowel in case of chronic pancreatitis are caused by disturbances in the first stage of membranous intestinal digestion, observed at early stages of disease and begin to progress with the disease duration.

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