Saratov JOURNAL of Medical and Scientific Research

Maljuzhinskaya N.V.

Volgograd State Medical University, Department of Clinical Pharmacology and Intensive Therapy with Courses of Clinical Pharmacology and Clinical Allergology, Assistant Professor, Candidate of Medical Science

Estimates of total costs for treatment of chronic id-iopathic urticaria in adults, depending on the scheme antiallergic therapy

Year: 2010, volume 6 Issue: №4 Pages: 759-762
Heading: Clinical Pharmacology Article type: Original article
Authors: Petrov V.I., Razvalyaeva A.V., Malyuzhinskaya N.V., Gorbunov V.A.
Organization: Volgograd State Medical University
Summary:

Objective: Comparative economic evaluation of clinical application of various alternatives to anti-allergic therapy. The total budget for the treatment of severe chronic idiopathic urticaria for the 12 weeks of the study (4 weeks of therapy and 8 weeks of observation) was assessed according to treatment: Group 1 -cyclosporine2.5 mg/kg/day, Group 2-cetirizine 20 mg and ranitidine 300 mg/day, Group 3 - cetirizine 20 mg. These groups were evaluated by direct medical, direct nonmedical and indirect costs. It was found that the lowest overall cost of treating 100 patients with severe CIU, within 12 weeks of the study were recorded in the group, where a combined therapy of cetirizine 10 mg ranitidine 300 mg. The greatest costs were associated with the appointment of therapy cetirizine 20 mg

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Russian version of CU-Q2oL questionnaire for estimation of quality of life of patients with chronic urticaria

Year: 2010, volume 6 Issue: №3 Pages: 566-569
Heading: Immunology and allergology Article type: Original article
Authors: Nekrasova Е.Е., Razvalyaeva A.V., Malyuzhinskaya N.V.
Organization: Volgograd State Medical University
Summary:

The research objective is to work out the creation of Russian-language questionnaire for assessing quality of life of patients with chronic urticaria by adapting the questionnaire «Chronic Urticaria Quality of Life Questionnaire» (CU-Q2oL) to Russian conditions. The study involved 150 patients aged 18 to 50 years (32,41±6,02) with chronic urticaria. Cultural and linguistic adaptation of the questionnaire was conducted according to international methodology. Evaluation of reliability was conducted by calculating Cronbach's б-coefficient, constructive validity -the method of «known groups» and the identification of mutual correlations with the scales of the SF-36 questionnaire, sensitivity-by comparing the quality of life before and after the treatment. High values of Cronbach's б-coefficient (>0.72) were obtained, the dependence of quality of life on the severity of chronic urticaria was proved to be significant, as well as the sensitivity of the questionnaire to clinical changes. The research findings confirmed good psychometric properties of Russian version of the questionnaire. The developed version of the questionnaire is a reliable, valid and sensitive device for assessing the quality of life in patients with chronic urticaria, and may be used in scientific and clinical research.

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Clinical efficiency of cyclosporine in chronic idiopathic urticaria in adults

Year: 2010, volume 6 Issue: №2 Pages: 248-252
Heading: Clinical Pharmacology Article type: Original article
Authors: V.I. Petrov, A.V. Razvalyaeva, S.A. Grebnev, N.V. Malyuzhinskaya
Organization: Volgograd State Medical University
Summary:

The purpose of the research is to evaluate the clinical effectiveness of cyclosporine and other antihistamines in patients with chronic forms of urticaria resistant to basic first-line therapy. Open randomized controlled study has been performed in parallel groups. 53 patients with chronic idiopathic urticaria ages 18-50 years have been examined. In case of ineffectiveness of previous therapy, patients have been randomized into 2 groups: group I receiving cyclosporine (Sandimmune Neoral ®) 2,5 mg/kg/day, group II receiving cetirizine (Zyrtec ®) 10 mg/day and ranitidine (Zantac ®) 300 mg/day orally. It has been found that the administration of cyclosporine in patients with severe chronic idiopathic urticaria provides a more rapid achievement of clinical effect than the therapy with H1/H2 histamine antagonists. It is confirmed by a significant decrease of total index of severity of illness and major symptoms of skin lesions. This tendency towards normalization of quality of life of patients taking cyclosporine remains during 8 weeks after the medication. Thus administration of cyclosporine can be considered as therapy of choice in patients with chronic idio-pathic urticaria with a severe course and ineffective long-term therapy with antihistamines / systemic corticosteroids

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Clinical efficiency of desloratadine therapy in children with persistent form of allergic rhinitis and its effect on bronchial asthma symptoms

Year: 2010, volume 6 Issue: №1 Pages: 073-076
Heading: Internal Diseases Article type: Original article
Authors: V.I. Petrov, N.V. Maljuzhinskaya, I.N. Shishimorov
Organization: Volgograd State Medical University
Summary:

The research goal was to study the clinical efficiency of desloratadine therapy in children with persistent form of allergic rhinitis and to evaluate its effect on bronchial asthma symptoms.
A prospective, randomized, open, parallel-group study of the effectiveness of desloratadine in children with persistent allergic rhinitis aged 2 - 16 in a four-week term was carried out. the effectiveness of therapy was evaluated by dynamics of clinical symptoms and rhinomanometry.
the study showed that desloratadine was an effective medication in treatment of persistent allergic rhinitis in children of different age groups. It controlled nasal and other symptoms of allergic rhinitis and provided the reduction of stuffiness in nose and improvement of breathing through the nose. the medication significantly effected histamine-induced symptoms (itching, sneezing, rhinorrhea). In children with allergic rhinitis and bronchial asthma the positive dynamics of symptoms of asthma was observed.
the effectiveness of treatment with desloratadine in children with isolated allergic rhinitis was proved to be higher than in patients with concomitant bronchial asthma

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